Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C20H22FN3O |
| Molecular Weight | 339.4066 |
| Optical Activity | ( + ) |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C[C@H]1C[C@@H]1CN2C(C)=C(C)C3=CN=NC(OCC4=CC=C(F)C=C4)=C23
InChI
InChIKey=NXPLYKRKIFPEOA-BLLLJJGKSA-N
InChI=1S/C20H22FN3O/c1-12-8-16(12)10-24-14(3)13(2)18-9-22-23-20(19(18)24)25-11-15-4-6-17(21)7-5-15/h4-7,9,12,16H,8,10-11H2,1-3H3/t12-,16+/m0/s1
| Molecular Formula | C20H22FN3O |
| Molecular Weight | 339.4066 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Pharmacological profile of novel acid pump antagonist 7-(4-fluorobenzyloxy)-2,3-dimethyl-1-{[(1S,2S)-2-methyl cyclopropyl]methyl}-1H-pyrrolo[2,3-d]pyridazine (CS-526). | 2007 Oct |
|
| The effect of subchronic administration of 7-(4-fluorobenzyloxy)-2,3-dimethyl-1-{[(1S,2S)-2-methylcyclopropyl]methyl}-1H-pyrrolo[2,3-d]pyridazine (CS-526), a novel acid pump antagonist, on gastric acid secretion and gastrin levels in rats. | 2008 Jul |
|
| Pharmacodynamic and pharmacokinetic evaluation of CS-526 in cynomolgus monkeys. | 2009 Dec |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:24:27 GMT 2023
by
admin
on
Fri Dec 15 16:24:27 GMT 2023
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| Record UNII |
K82NW38NLW
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| Record Status |
Validated (UNII)
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| Record Version |
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313272-12-7
Created by
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K82NW38NLW
Created by
admin on Fri Dec 15 16:24:27 GMT 2023 , Edited by admin on Fri Dec 15 16:24:27 GMT 2023
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |
Class: Antiulcer, Gastrokinetic; Mechanism of Action: Potassium-competitive acid blocker; Highest Development Phase: Discontinued for Gastro-oesophageal reflux and Peptic ulcer; Most Recent Event: 10 Oct 2003 Phase-I clinical trials in Gastro-oesophageal reflux in USA (PO)
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