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Details

Stereochemistry ABSOLUTE
Molecular Formula C22H29F3O3
Molecular Weight 398.4591
Optical Activity UNSPECIFIED
Defined Stereocenters 7 / 7
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FLUMEDROXONE

SMILES

[H][C@@]12CC[C@](O)(C(C)=O)[C@@]1(C)CC[C@@]3([H])[C@@]2([H])C[C@@H](C4=CC(=O)CC[C@]34C)C(F)(F)F

InChI

InChIKey=CDZJOBWKHSYNMO-SCUQKFFVSA-N
InChI=1S/C22H29F3O3/c1-12(26)21(28)9-6-16-14-11-18(22(23,24)25)17-10-13(27)4-7-19(17,2)15(14)5-8-20(16,21)3/h10,14-16,18,28H,4-9,11H2,1-3H3/t14-,15+,16+,18+,19-,20+,21+/m1/s1

HIDE SMILES / InChI

Molecular Formula C22H29F3O3
Molecular Weight 398.4591
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 7 / 7
E/Z Centers 0
Optical Activity UNSPECIFIED

Flumedroxone is a progestative agent. It is a pregnane derivative substituted at C-6 by a trifluoromethyl group. It was tested whether flumedroxone had prophylactic value in migraine. No benefit was found in males, or in females with no history of menstrual exacerbation of migraine. In women whose migraine was worse around the time of menstruation flumedroxone resulted in statistically fewer headaches of less severity. With the dose used in this trial side-effects were frequent, the commonest being polymenorrhagia, which occurred in half the women of reproductive age.

Approval Year

Patents

Patents

Sample Use Guides

10 to 20 mg. daily, in divided doses
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:20:20 UTC 2023
Edited
by admin
on Fri Dec 15 16:20:20 UTC 2023
Record UNII
K80185F39X
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FLUMEDROXONE
INN   WHO-DD  
INN  
Official Name English
Flumedroxone [WHO-DD]
Common Name English
WG-537 FREE BASE
Code English
17-HYDROXY-6.ALPHA.-(TRIFLUOROMETHYL)PREGN-4-ENE-3,20-DIONE
Systematic Name English
flumedroxone [INN]
Common Name English
Classification Tree Code System Code
WHO-ATC N02CB01
Created by admin on Fri Dec 15 16:20:20 UTC 2023 , Edited by admin on Fri Dec 15 16:20:20 UTC 2023
WHO-VATC QN02CB01
Created by admin on Fri Dec 15 16:20:20 UTC 2023 , Edited by admin on Fri Dec 15 16:20:20 UTC 2023
NCI_THESAURUS C521
Created by admin on Fri Dec 15 16:20:20 UTC 2023 , Edited by admin on Fri Dec 15 16:20:20 UTC 2023
Code System Code Type Description
EVMPD
SUB07695MIG
Created by admin on Fri Dec 15 16:20:20 UTC 2023 , Edited by admin on Fri Dec 15 16:20:20 UTC 2023
PRIMARY
CAS
15687-21-5
Created by admin on Fri Dec 15 16:20:20 UTC 2023 , Edited by admin on Fri Dec 15 16:20:20 UTC 2023
PRIMARY
DRUG BANK
DB13610
Created by admin on Fri Dec 15 16:20:20 UTC 2023 , Edited by admin on Fri Dec 15 16:20:20 UTC 2023
PRIMARY
NCI_THESAURUS
C65715
Created by admin on Fri Dec 15 16:20:20 UTC 2023 , Edited by admin on Fri Dec 15 16:20:20 UTC 2023
PRIMARY
FDA UNII
K80185F39X
Created by admin on Fri Dec 15 16:20:20 UTC 2023 , Edited by admin on Fri Dec 15 16:20:20 UTC 2023
PRIMARY
EPA CompTox
DTXSID40905080
Created by admin on Fri Dec 15 16:20:20 UTC 2023 , Edited by admin on Fri Dec 15 16:20:20 UTC 2023
PRIMARY
INN
2035
Created by admin on Fri Dec 15 16:20:20 UTC 2023 , Edited by admin on Fri Dec 15 16:20:20 UTC 2023
PRIMARY
MESH
C007732
Created by admin on Fri Dec 15 16:20:20 UTC 2023 , Edited by admin on Fri Dec 15 16:20:20 UTC 2023
PRIMARY
ChEMBL
CHEMBL2104932
Created by admin on Fri Dec 15 16:20:20 UTC 2023 , Edited by admin on Fri Dec 15 16:20:20 UTC 2023
PRIMARY
SMS_ID
100000080705
Created by admin on Fri Dec 15 16:20:20 UTC 2023 , Edited by admin on Fri Dec 15 16:20:20 UTC 2023
PRIMARY
PUBCHEM
20055352
Created by admin on Fri Dec 15 16:20:20 UTC 2023 , Edited by admin on Fri Dec 15 16:20:20 UTC 2023
PRIMARY
WIKIPEDIA
FLUMEDROXONE
Created by admin on Fri Dec 15 16:20:20 UTC 2023 , Edited by admin on Fri Dec 15 16:20:20 UTC 2023
PRIMARY
DRUG CENTRAL
4547
Created by admin on Fri Dec 15 16:20:20 UTC 2023 , Edited by admin on Fri Dec 15 16:20:20 UTC 2023
PRIMARY
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