ESUPRONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C13H14O5S
Molecular Weight	282.312
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCS(=O)(=O)OC1=CC2=C(C=C1)C(C)=C(C)C(=O)O2

InChI

InChIKey=CHDGAVDQRSPBTA-UHFFFAOYSA-N

InChI=1S/C13H14O5S/c1-4-19(15,16)18-10-5-6-11-8(2)9(3)13(14)17-12(11)7-10/h5-7H,4H2,1-3H3

HIDE SMILES / InChI

Molecular Formula	C13H14O5S
Molecular Weight	282.312
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://adisinsight.springer.com/drugs/800005281 | https://www.ncbi.nlm.nih.gov/pubmed/9174681 | https://www.ncbi.nlm.nih.gov/pubmed/10027835

Esuprone (LU 43839) is a monoamine oxidase type A inhibitor. Esuprone proved to be an effective anticonvulsant in the kindling model. Esuprone was undergoing phase II clinical trials with Knoll (BASF Pharma) in Germany as an antidepressant.

CNS Activity

Originator

Approval Year

PubMed

Title	Date	PubMed
MAO-A inhibition in brain after dosing with esuprone, moclobemide and placebo in healthy volunteers: in vivo studies with positron emission tomography.	1997	9174681
Inhibition of monoamine oxidase type A, but not type B, is an effective means of inducing anticonvulsant activity in the kindling model of epilepsy.	1999 Mar	10027835
Synthesis and study of a series of 3-arylcoumarins as potent and selective monoamine oxidase B inhibitors.	2011 Oct 27	21923181

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:53:20 GMT 2023` Edited by `admin` on `Sat Dec 16 17:53:20 GMT 2023`
Record UNII	K7EB9E48ZE
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ESUPRONE

Official Name

English

esuprone [INN]

Common Name

English

7-HYDROXY-3,4-DIMETHYLCOUMARIN ETHANESULFONATE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C667