OXDRALAZINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H15N5O2
Molecular Weight	213.237
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NNC1=NN=C(C=C1)N(CCO)CCO

InChI

InChIKey=POFDNYKJHWKGDU-UHFFFAOYSA-N

InChI=1S/C8H15N5O2/c9-10-7-1-2-8(12-11-7)13(3-5-14)4-6-15/h1-2,14-15H,3-6,9H2,(H,10,11)

HIDE SMILES / InChI

Molecular Formula	C8H15N5O2
Molecular Weight	213.237
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6345596 | https://www.ncbi.nlm.nih.gov/pubmed/536472

Oxdralazine is a peripheral vasodilator that was studied for patients with severe essential hypertension. The clinical trial has shown that at the end of the third month 25 patients on the triple regimen (chlorthalidone plus oxdralazine plus propranolol) achieved a stable diastolic blood pressure of 90 mm Hg or less. However, information about the further development of this drug is not available.

Approval Year

PubMed

Title	Date	PubMed

Onthe pharmacology of 3-hydrazino-6-(N,N-bis(2-hydroxyethyl)amino)-pyridazine-dihydrochloride (L 6150).	1973 Nov	4801666
A comparative study of the hemodynamic effects of single intravenous doses of 3-hydrazino-6-[N,N-bis-(2-hydroxyethyl)-amino]-pyridazine-dihydrochloride and hydralazine.	1976	1037254
Systemic and coronary haemodynamic effects of the new hypotensive drug L 6150.	1976	1027634
Clinical and haemodynamic study of a new vasodilator drug L6150 (3-[bis-(2-hydroxyethyl)amino]-6-hydrazinopyridazine) in man.	1976 Dec	799568
Synthesis of three metabolites of 3-hydrazino-6-[bis-(2-hydroxyethyl)amino]pyridazine. A new rearrangement of 3-[1-methylethyliden)hydrazino] derivative.	1978 Aug	744255
Antihypertensive and antidiuretic effects of 3-hydrazino-6-[N, N-bis (2-hydroxyethyl) amino]-pyridazine (L 6150) in rats.	1978 Jun	702944
Disposition and metabolism of 3-hydrazino-6-[N,N-bis(2-hydroxyethyl)amino] pyridazine dihydrochloride in man.	1979	488135
Long-term study of oxdralazine in hypertensive patients.	1979	396926

Patents

Sample Use Guides

In Vivo Use Guide

Oxdralazine was given orally in doses of 15 to 30 mg to 7 subjects with hypertension

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 18:02:06 GMT 2023` Edited by `admin` on `Sat Dec 16 18:02:06 GMT 2023`
Record UNII	K6SU81C9V1
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

OXDRALAZINE

Official Name

English

oxdralazine [INN]

Common Name

English

2,2'-((6-HYDRAZINO-3-PYRIDAZINYL)IMINO)DIETHANOL

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29707