Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C19H28N2O5 |
| Molecular Weight | 364.436 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]1(C[C@H](O)[C@@H](CO)O1)N2C=C3C=C(CCCCCCCC)OC3=NC2=O
InChI
InChIKey=WNJULOODRKXPLP-GVDBMIGSSA-N
InChI=1S/C19H28N2O5/c1-2-3-4-5-6-7-8-14-9-13-11-21(19(24)20-18(13)25-14)17-10-15(23)16(12-22)26-17/h9,11,15-17,22-23H,2-8,10,12H2,1H3/t15-,16+,17+/m0/s1
| Molecular Formula | C19H28N2O5 |
| Molecular Weight | 364.436 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Potent and selective inhibition of varicella-zoster virus (VZV) by nucleoside analogues with an unusual bicyclic base. | 1999 Nov 4 |
|
| Highly potent and selective inhibition of varicella-zoster virus by bicyclic furopyrimidine nucleosides bearing an aryl side chain. | 2000 Dec 28 |
|
| Anti-varicella-zoster virus bicyclic nucleosides: replacement of furo by pyrro base reduces antiviral potency. | 2000 Sep |
|
| Novel aryl substituted bicyclic furo nucleosides as extremely potent and selective anti-VZV agents. | 2001 Apr-Jul |
|
| Bicyclic nucleoside inhibitors of Varicella-Zoster Virus (VZV): the effect of terminal unsaturation in the side chain. | 2001 Feb 12 |
|
| Specific recognition of the bicyclic pyrimidine nucleoside analogs, a new class of highly potent and selective inhibitors of varicella-zoster virus (VZV), by the VZV-encoded thymidine kinase. | 2002 Feb |
|
| Chemotherapy of varicella-zoster virus by a novel class of highly specific anti-VZV bicyclic pyrimidine nucleosides. | 2002 Jul 18 |
|
| Lack of susceptibility of bicyclic nucleoside analogs, highly potent inhibitors of varicella-zoster virus, to the catabolic action of thymidine phosphorylase and dihydropyrimidine dehydrogenase. | 2002 May |
|
| Bicyclic nucleoside inhibitors of varicella-zoster virus: effect of terminal aryl substitution in the side-chain. | 2002 Sep |
|
| Highly potent and selective inhibition of varicella-zoster virus replication by bicyclic furo[2,3-d]pyrimidine nucleoside analogues. | 2003 May |
|
| Synthesis and antiviral evaluation of some 3'-fluoro bicyclic nucleoside analogues. | 2004 |
|
| Inactivity of the bicyclic pyrimidine nucleoside analogues against simian varicella virus (SVV) does not correlate with their substrate activity for SVV-encoded thymidine kinase. | 2004 Mar 19 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 18:32:52 GMT 2023
by
admin
on
Sat Dec 16 18:32:52 GMT 2023
|
| Record UNII |
K647SW1D14
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
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K647SW1D14
Created by
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492114
Created by
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215668-64-7
Created by
admin on Sat Dec 16 18:32:52 GMT 2023 , Edited by admin on Sat Dec 16 18:32:52 GMT 2023
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