U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Structurally Diverse
Created
by admin
on Sat Dec 16 18:35:55 GMT 2023
Edited
by admin
on Sat Dec 16 18:35:55 GMT 2023
Source Materials Class ORGANISM
Source Materials Type AUTOLOGOUS HUMAN
Source Materials State LIVE GENETICALLY MODIFIED
Source Materials Parent
Part BLOOD
Fraction Name Peripheral blood mononuclear cells
Record UNII
K5CXA4X5U8
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
RELMACABTAGENE AUTOLEUCEL
INN  
Official Name English
Carteyva
Brand Name English
AUTOLOGOUS CD4+ AND CD8+ T CELLS, ENRICHED FROM PERIPHERAL BLOOD MONONUCLEAR CELLS (PBMCS) TRANSDUCED WITH A NONREPLICATIVE SELF-INACTIVATING (SIN) LENTIVIRAL VECTOR ENCODING A CHIMERIC ANTIGEN RECEPTOR (CAR) CONSISTING OF THE HUMAN CD19-SPECIFIC SCFV, A
Common Name English
relma-cel
Common Name English
relmacabtagene autoleucel [INN]
Common Name English
JWCAR-029
Code English
Relmacabtagene autoleucel [WHO-DD]
Common Name English
Code System Code Type Description
FDA UNII
K5CXA4X5U8
Created by admin on Sat Dec 16 18:35:55 GMT 2023 , Edited by admin on Sat Dec 16 18:35:55 GMT 2023
PRIMARY
INN
11372
Created by admin on Sat Dec 16 18:35:55 GMT 2023 , Edited by admin on Sat Dec 16 18:35:55 GMT 2023
PRIMARY
NCI_THESAURUS
C155878
Created by admin on Sat Dec 16 18:35:55 GMT 2023 , Edited by admin on Sat Dec 16 18:35:55 GMT 2023
PRIMARY
Related Record Type Details
TARGET->CYTOTOXIC T-CELL
Related Record Type Details
ACTIVE MOIETY

Agent Modifications

Modification Process Modification Role Modification Type Amount Fragment Name Fragment ID
LENTIVIRAL TRANSFECTION TRANSFECTION UNSPECIFIED SUBSTANCE ec691156

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
VECTOR EXPRESSED PROTEIN LISOCABTAGENE MARALEUCEL CAR-T RECEPTOR E18VZQ3GB1
VECTOR EXPRESSED PROTEIN UNSPECIFIED SUBSTANCE
1cd64bba
(not in database)
INSERTED GENE EXPRESSION VECTOR RELMACABTAGENE AUTOLEUCEL TRANSGENE INSERT Q77GF33B7N
Name Property Type Amount Referenced Substance Defining Parameters References
ANTIGEN EXPRESSED BIOLOGICAL
ANTIGEN EXPRESSED BIOLOGICAL
ANTIGEN EXPRESSED BIOLOGICAL