FENAMOLE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H7N5
Molecular Weight	161.164
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC1=NN=NN1C2=CC=CC=C2

InChI

InChIKey=ULIDRMKBVYYVIQ-UHFFFAOYSA-N

InChI=1S/C7H7N5/c8-7-9-10-11-12(7)6-4-2-1-3-5-6/h1-5H,(H2,8,9,11)

HIDE SMILES / InChI

Molecular Formula	C7H7N5
Molecular Weight	161.164
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.google.com/patents/US3278381 | (1974) Prostaglandin synthetase inhibitors, page 30, retrieved from: https://books.google.ru/books?id=dwxtAAAAMAAJ

Fenamole is a muscle relaxant. It is effectively inhibits muscle spasms at good levels for a four hours and at significant levels for six hours. Clinical benefits were derived in patients with spasticity-spasm for periods up to 24 hours after a single oral dose. Fenamole is relatively free of adverse side effects particularly in the central nervous system. It is a potent copper chelator. It was once investigated as a potential antirheumatic agent in man.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Copper 16 Target ID: Copper Sources: (1974) Prostaglandin synthetase inhibitors, page 30, retrieved from: https://books.google.ru/books?id=dwxtAAAAMAAJ	Chelating Agent 142

Conditions

Condition	Modality	Targets	Highest Phase	Product
Muscle spasm 40 Sources: https://www.google.com/patents/US3278381	Primary		Not Provided 504	Unknown Approved Use Unknown
Rheumatic diseases 30 Sources: DOI: 10.1016/S0065-7743(08)60069-X (1974) Prostaglandin synthetase inhibitors, page 30, retrieved from: https://books.google.ru/books?id=dwxtAAAAMAAJ	Palliative		Not Provided 504	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Two derivatives of 5-aminotetrazole: 5-amino-1-phenyltetrazole and 5-amino-1-(1-naphthyl)tetrazole.	2003 Dec	14671372
Synthesis, characterization, and biological evaluation of new tetrazole-based platinum(II) and palladium(II) chlorido complexes--potent cisplatin analogues and their trans isomers.	2013 Mar	23305964

Patents

Sample Use Guides

In Vivo Use Guide

800 mg single dose

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:10:42 UTC 2023` Edited by `admin` on `Fri Dec 15 15:10:42 UTC 2023`
Record UNII	K4H264PBQ7
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

FENAMOLE

Official Name

English

NSC-25413

Code

English

PAT

Code

English

fenamole [INN]

Common Name

English

AL 0559

Code

English

1H-TETRAZOL-5-AMINE, 1-PHENYL-

Systematic Name

English

AL-0559

Code

English

FENAMOLE [USAN]

Common Name

English

P-463

Code

English

5-Amino-1-phenyl-1H-tetrazole

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C257