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Details

Stereochemistry RACEMIC
Molecular Formula C16H14O5
Molecular Weight 286.2794
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GUAIMESAL

SMILES

COC1=C(OC2(C)OC(=O)C3=C(O2)C=CC=C3)C=CC=C1

InChI

InChIKey=PSVDIHULUCLEJE-UHFFFAOYSA-N
InChI=1S/C16H14O5/c1-16(20-14-10-6-5-9-13(14)18-2)19-12-8-4-3-7-11(12)15(17)21-16/h3-10H,1-2H3

HIDE SMILES / InChI

Molecular Formula C16H14O5
Molecular Weight 286.2794
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Guaimesal was studied for the treatment of exacerbated chronic bronchitis

Approval Year

PubMed

PubMed

TitleDatePubMed
[Clinical evaluation of the therapeutic efficacy of a new antiphlogistic and mucus-regulating drug, guaimesal, in acute and chronic bronchopneumopathies].
1984 Sep 15
[Guaimesal capsules in the treatment of exacerbated chronic bronchitis].
1984 Sep 30
Double-blind, placebo-controlled clinical evaluation of guaimesal in outpatients.
1989 May-Jun
Gas chromatographic-tandem mass spectrometric determination of acetylsalicylic acid in human plasma after oral administration of low-dose aspirin and guaimesal.
1998 May 8
Patents

Patents

Sample Use Guides

One hundred and forty outpatients, males and females aged 14 to 70 years, with acute febrile bronchitis, afebrile chronic bronchitis, or flares of chronic bronchitis were treated for seven days with one soft gelatin capsule (500 mg) of guaimesal thrice daily or matching placebo
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Fri Dec 15 17:34:28 GMT 2023
Edited
by admin
on Fri Dec 15 17:34:28 GMT 2023
Record UNII
K43273G1CW
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
GUAIMESAL
INN   MART.   WHO-DD  
INN  
Official Name English
(±)-2-(O-METHOXYPHENOXY)-2-METHYL-1,3-BENZODIOXAN-4-ONE
Common Name English
guaimesal [INN]
Common Name English
GUAIMESAL [MART.]
Common Name English
Guaimesal [WHO-DD]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C257
Created by admin on Fri Dec 15 17:34:28 GMT 2023 , Edited by admin on Fri Dec 15 17:34:28 GMT 2023
Code System Code Type Description
SMS_ID
100000084243
Created by admin on Fri Dec 15 17:34:28 GMT 2023 , Edited by admin on Fri Dec 15 17:34:28 GMT 2023
PRIMARY
ChEMBL
CHEMBL2105115
Created by admin on Fri Dec 15 17:34:28 GMT 2023 , Edited by admin on Fri Dec 15 17:34:28 GMT 2023
PRIMARY
INN
5366
Created by admin on Fri Dec 15 17:34:28 GMT 2023 , Edited by admin on Fri Dec 15 17:34:28 GMT 2023
PRIMARY
DRUG CENTRAL
1337
Created by admin on Fri Dec 15 17:34:28 GMT 2023 , Edited by admin on Fri Dec 15 17:34:28 GMT 2023
PRIMARY
PUBCHEM
71250
Created by admin on Fri Dec 15 17:34:28 GMT 2023 , Edited by admin on Fri Dec 15 17:34:28 GMT 2023
PRIMARY
MESH
C043484
Created by admin on Fri Dec 15 17:34:28 GMT 2023 , Edited by admin on Fri Dec 15 17:34:28 GMT 2023
PRIMARY
FDA UNII
K43273G1CW
Created by admin on Fri Dec 15 17:34:28 GMT 2023 , Edited by admin on Fri Dec 15 17:34:28 GMT 2023
PRIMARY
NCI_THESAURUS
C65824
Created by admin on Fri Dec 15 17:34:28 GMT 2023 , Edited by admin on Fri Dec 15 17:34:28 GMT 2023
PRIMARY
CAS
81674-79-5
Created by admin on Fri Dec 15 17:34:28 GMT 2023 , Edited by admin on Fri Dec 15 17:34:28 GMT 2023
PRIMARY
EVMPD
SUB07975MIG
Created by admin on Fri Dec 15 17:34:28 GMT 2023 , Edited by admin on Fri Dec 15 17:34:28 GMT 2023
PRIMARY
EPA CompTox
DTXSID00868622
Created by admin on Fri Dec 15 17:34:28 GMT 2023 , Edited by admin on Fri Dec 15 17:34:28 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY