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Details

Stereochemistry RACEMIC
Molecular Formula C16H20N4O2
Molecular Weight 300.3556
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of APAZONE

SMILES

CCCC1C(=O)N2N(C1=O)C3=C(C=CC(C)=C3)N=C2N(C)C

InChI

InChIKey=MPHPHYZQRGLTBO-UHFFFAOYSA-N
InChI=1S/C16H20N4O2/c1-5-6-11-14(21)19-13-9-10(2)7-8-12(13)17-16(18(3)4)20(19)15(11)22/h7-9,11H,5-6H2,1-4H3

HIDE SMILES / InChI

Molecular Formula C16H20N4O2
Molecular Weight 300.3556
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description

Azapropazone is a non-steroidal anti-inflammatory drug. It is indicated for use in the treatment of rheumatoid arthritis, osteo-arthritis and gout. Gastro-intestinal disturbances, allergic skin rashes and photosensitivity, headache, vertigo, oedema and kidney impairment may occur. Gastro-intestinal bleeding and angioedema have been reported. Pre-treatment with this drug failed to modify plasma concentrations of phenobarbitone. Brain levels of imipramine or desmethyl imipramine were unaffected 60 minutes after oral administration of imipramine.

CNS Activity

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
3.0 µM [IC50]
15.0 µM [IC50]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Rheumox
Primary
Rheumox
Primary
Rheumox

PubMed

Sample Use Guides

In Vivo Use Guide
The usual dose is 1200 mg per day, given as 600 mg twice daily.
Route of Administration: Oral
In Vitro Use Guide
Azapropazone is an inhibitor of a variety of neutrophil functions (migration, aggregation, superoxide production) at 40-400 ug/ml-1
Substance Class Chemical
Record UNII
K2VOT966ZI
Record Status Validated (UNII)
Record Version