2-CHLORO-3'-DEOXYADENOSINE

NC1=NC(Cl)=NC2=C1N=CN2[C@@H]3O[C@H](CO)C[C@H]3O

InChIKey=HNSLUZJFGNTTEV-OBXARNEKSA-N

InChI=1S/C10H12ClN5O3/c11-10-14-7(12)6-8(15-10)16(3-13-6)9-5(18)1-4(2-17)19-9/h3-5,9,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,9+/m0/s1

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

PubMed

Title	Date	PubMed
Metabolic effects of 3'-deoxyadenosine (cordycepin) and 2-halo-3'-deoxyadenosine on repair of X-ray-induced potentially lethal damage in Chinese hamster V79 cells.	1988 May	2836881
Synthesis of the 2-chloro analogues of 3'-deoxyadenosine, 2',3'-dideoxyadenosine, and 2',3'-didehydro-2',3'-dideoxyadenosine as potential antiviral agents.	1989 May	2785212
2-chlorodeoxyadenosine (2-CdA) does not change the expression of Fas antigen on chronic lymphocytic leukaemia cells.	2000	11783506
Induction of apoptosis by 2-chloro-2'deoxyadenosine (2-CdA) alone and in combination with other cytotoxic drugs: synergistic effects on normal and neoplastic lymphocytes by addition of doxorubicin and mitoxantrone.	2000 Feb	10784401
Cladribine with or without prednisone in the treatment of previously treated and untreated B-cell chronic lymphocytic leukaemia - updated results of the multicentre study of 378 patients.	2000 Feb	10691866
Peliosis hepatis after treatment with 2-chloro-3'-deoxyadenosine.	2000 Jun	10881786

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:10:38 GMT 2023` Edited by `admin` on `Fri Dec 15 18:10:38 GMT 2023`
Record UNII	JYW18Y92UP
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

2-CHLORO-3'-DEOXYADENOSINE

Systematic Name

English

ADENOSINE,2-CHLORO-3'-DEOXY-

Common Name

English

Code System Code Type Description

EPA CompTox

DTXSID90150942