Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C42H70O35 |
Molecular Weight | 1134.9842 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 35 / 35 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12O[C@H](CO)[C@@]([H])(O[C@@]3([H])O[C@H](CO)[C@@]([H])(O[C@@]4([H])O[C@H](CO)[C@@]([H])(O[C@@]5([H])O[C@H](CO)[C@@]([H])(O[C@@]6([H])O[C@H](CO)[C@@]([H])(O[C@@]7([H])O[C@H](CO)[C@@]([H])(O[C@@]8([H])O[C@H](CO)[C@@]([H])(O1)[C@H](O)[C@H]8O)[C@H](O)[C@H]7O)[C@H](O)[C@H]6O)[C@H](O)[C@H]5O)[C@H](O)[C@H]4O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O
InChI
InChIKey=WHGYBXFWUBPSRW-FOUAGVGXSA-N
InChI=1S/C42H70O35/c43-1-8-29-15(50)22(57)36(64-8)72-30-9(2-44)66-38(24(59)17(30)52)74-32-11(4-46)68-40(26(61)19(32)54)76-34-13(6-48)70-42(28(63)21(34)56)77-35-14(7-49)69-41(27(62)20(35)55)75-33-12(5-47)67-39(25(60)18(33)53)73-31-10(3-45)65-37(71-29)23(58)16(31)51/h8-63H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-/m1/s1
Molecular Formula | C42H70O35 |
Molecular Weight | 1134.9842 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 35 / 35 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/28155026Curator's Comment: https://www.ncbi.nlm.nih.gov/pubmed/27184436 | https://www.drugs.com/inactive/betadex-21.html | http://www.drugfuture.com/pharmacopoeia/usp32/pub/data/v32270/usp32nf27s0_m8744.html
Sources: https://www.ncbi.nlm.nih.gov/pubmed/28155026
Curator's Comment: https://www.ncbi.nlm.nih.gov/pubmed/27184436 | https://www.drugs.com/inactive/betadex-21.html | http://www.drugfuture.com/pharmacopoeia/usp32/pub/data/v32270/usp32nf27s0_m8744.html
Betadex is a nonreducing cyclic compound composed of seven alpha-(1-4) linked D-glucopyranosyl units. It is a pharmacologically inactive substance. Betadex is useful for stabilizing, solubilizing or delivering intermediate size molecules. Cyclodextrins are cyclic oligosaccharides that have been used to modulate the composition of cholesterol and other lipids in biological membranes and have also been used as pharmaceutical excipients in the formulation of hydrophobic drugs. More recently, 2-Hydroxypropyl-β-cyclodextrins (HPβCDs) have gained attention as a potential therapeutic intervention for Niemann-Pick Disease Type C1 (NPC1) disease. HPβCDs are complex mixtures of different species, and variations in production may lead to differences in composition. 2-Hydroxypropyl-β-cyclodextrin dose-dependent effects against dysfunctional intracellular cholesterol trafficking in NPC1 cells.
CNS Activity
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: GO:0010879 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27184436 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Inactive ingredient | Brexidol Approved UseBrexidol (piroxicam-beta-cyclodextrin) is a product indicated for the treatment of mild to severe acute pain. Launch Date9.2041917E11 |
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Inactive ingredient | Unknown Approved UseUnknown |
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Primary | Unknown Approved UseUnknown |
Sample Use Guides
In Vivo Use Guide
Sources: https://clinicaltrials.gov/ct2/show/NCT02912793
15000, 2000 and 2500 mg/kg slow infusion for 8h every 2 weeks.
Route of Administration:
Intravenous
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/27184436
Treatment of Chinese hamster ovary cells with 2-hydroxypropyl-β-cyclodextrin induced a decrease in cell viability in a dosedependent manner. Significant cytotoxicity was observed in cells treated with ≥50 mM 2-hydroxypropyl-β-cyclodextrin.
Substance Class |
Chemical
Created
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on
Edited
Fri Dec 15 15:46:05 UTC 2023
by
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on
Fri Dec 15 15:46:05 UTC 2023
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Record UNII |
JV039JZZ3A
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Record Status |
Validated (UNII)
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Classification Tree | Code System | Code | ||
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CODEX ALIMENTARIUS (GSFA) |
INS-459
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JECFA EVALUATION |
INS-459
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NCI_THESAURUS |
C82130
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DSLD |
300 (Number of products:2)
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Code System | Code | Type | Description | ||
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6860
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C80917
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CHEMBL415690
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269471
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SUB05793MIG
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100000086075
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444041
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2971
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m3980
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C031215
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314334
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DB03995
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DTXSID1020358
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JV039JZZ3A
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231-493-2
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1362685
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74
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JV039JZZ3A
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1154569
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495055
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7585-39-9
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Related Record | Type | Details | ||
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PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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ACTIVE MOIETY |
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