Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C10H7NO3 |
| Molecular Weight | 189.1675 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)C1=C2C=CC=NC2=C(O)C=C1
InChI
InChIKey=JGRPKOGHYBAVMW-UHFFFAOYSA-N
InChI=1S/C10H7NO3/c12-8-4-3-7(10(13)14)6-2-1-5-11-9(6)8/h1-5,12H,(H,13,14)
| Molecular Formula | C10H7NO3 |
| Molecular Weight | 189.1675 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
8-Hydroxy-5-quinolinecarboxylic acid (IOX1) is the most potent broad-spectrum inhibitor of 2-oxoglutarate oxygenases, including the Jumonji C domain (JmjC) demethylases. IOX1 exerts its anti-proliferative and anti-migratory effects in vascular smooth muscle cells by regulating the expression of the cell cycle-related proteins, cyclin D1 and p21. IOX1 selectively silences α-globin expression in erythroid cells, without affecting the β-like globin expression or erythroid differentiation, thereby IOX1 has potential as a lead compound to develop a novel therapy for β-thalassemia.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1. | 2014 Mar |
|
| IOX1, a JMJD2A inhibitor, suppresses the proliferation and migration of vascular smooth muscle cells induced by angiotensin II by regulating the expression of cell cycle-related proteins. | 2016 Jan |
|
| Selective silencing of α-globin by the histone demethylase inhibitor IOX1: a potentially new pathway for treatment of β-thalassemia. | 2017 Mar |
Sample Use Guides
8-Hydroxy-5-quinolinecarboxylic acid (IOX1) reduced erythroid cell expansion by about 40% (fold expansion dropped from 18-fold to 11-fold) at 40μM concentration, but the proportion of viable cells remained unchanged over all dose levels. This suggests that IOX1 has a mild inhibitory action on erythroid cell proliferation in vitro, although it does not adversely affect cellular viability.
IOX1 suppresses the proliferation and migration of vascular smooth muscle cells induced by Ang II.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 10:00:02 GMT 2023
by
admin
on
Sat Dec 16 10:00:02 GMT 2023
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| Record UNII |
JM015YQC1C
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| Record Status |
Validated (UNII)
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| Record Version |
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459617
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JM015YQC1C
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DTXSID20207236
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5852-78-8
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admin on Sat Dec 16 10:00:02 GMT 2023 , Edited by admin on Sat Dec 16 10:00:02 GMT 2023
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