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Details

Stereochemistry ACHIRAL
Molecular Formula C29H37NO4
Molecular Weight 463.6084
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BUCROMARONE

SMILES

CCCCN(CCCC)CCCOC1=C(C)C=C(C=C1C)C(=O)C2=CC(=O)C3=CC=CC=C3O2

InChI

InChIKey=DYGLNTZLBQBOPT-UHFFFAOYSA-N
InChI=1S/C29H37NO4/c1-5-7-14-30(15-8-6-2)16-11-17-33-29-21(3)18-23(19-22(29)4)28(32)27-20-25(31)24-12-9-10-13-26(24)34-27/h9-10,12-13,18-20H,5-8,11,14-17H2,1-4H3

HIDE SMILES / InChI

Molecular Formula C29H37NO4
Molecular Weight 463.6084
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Bucromarone is a coronary vasodilator. It is a compound exhibiting a structural relationship with amiodarone, a widely used antiangorous and antiarrythmic drug. Bucromarone appeared promising in the treatment of cardiac arrhythmia. Bucromarone is rapidly concentrated in the tissues after intravenous administration, and mainly eliminated in the bile. Bucromarone is well absorbed through the gastrointestinal tract after per os administration, but after liver uptake through the portal vein and extensive metabolism, unchanged drug and its metabolites are mainly excreted in the bile. As compared with amiodarone, bucromarone seems more rapidly distributed in the tissues and eliminated from the organs and blood.

Approval Year

Sample Use Guides

Dose: 4.4 mmol/kg body weight
Route of Administration: Other
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:20:32 GMT 2023
Edited
by admin
on Fri Dec 15 16:20:32 GMT 2023
Record UNII
JI688O846T
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BUCROMARONE
INN   USAN  
INN   USAN  
Official Name English
4H-1-BENZOPYRAN-4-ONE, 2-(4-(3-(DIBUTYLAMINO)PROPOXY)-3,5-DIMETHYLBENZOYL)-
Systematic Name English
BUCROMARONE [USAN]
Common Name English
bucromarone [INN]
Common Name English
2-[4-[3-(Dibutylamino)propoxyl]-3,5-dimethylbenzoyl]chromone
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C47793
Created by admin on Fri Dec 15 16:20:33 GMT 2023 , Edited by admin on Fri Dec 15 16:20:33 GMT 2023
Code System Code Type Description
CAS
78371-66-1
Created by admin on Fri Dec 15 16:20:33 GMT 2023 , Edited by admin on Fri Dec 15 16:20:33 GMT 2023
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FDA UNII
JI688O846T
Created by admin on Fri Dec 15 16:20:33 GMT 2023 , Edited by admin on Fri Dec 15 16:20:33 GMT 2023
PRIMARY
EPA CompTox
DTXSID50868475
Created by admin on Fri Dec 15 16:20:33 GMT 2023 , Edited by admin on Fri Dec 15 16:20:33 GMT 2023
PRIMARY
PUBCHEM
132852
Created by admin on Fri Dec 15 16:20:33 GMT 2023 , Edited by admin on Fri Dec 15 16:20:33 GMT 2023
PRIMARY
ChEMBL
CHEMBL2107592
Created by admin on Fri Dec 15 16:20:33 GMT 2023 , Edited by admin on Fri Dec 15 16:20:33 GMT 2023
PRIMARY
SMS_ID
100000088435
Created by admin on Fri Dec 15 16:20:33 GMT 2023 , Edited by admin on Fri Dec 15 16:20:33 GMT 2023
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NCI_THESAURUS
C72577
Created by admin on Fri Dec 15 16:20:33 GMT 2023 , Edited by admin on Fri Dec 15 16:20:33 GMT 2023
PRIMARY
INN
5134
Created by admin on Fri Dec 15 16:20:33 GMT 2023 , Edited by admin on Fri Dec 15 16:20:33 GMT 2023
PRIMARY
USAN
X-84
Created by admin on Fri Dec 15 16:20:33 GMT 2023 , Edited by admin on Fri Dec 15 16:20:33 GMT 2023
PRIMARY
MESH
C059720
Created by admin on Fri Dec 15 16:20:33 GMT 2023 , Edited by admin on Fri Dec 15 16:20:33 GMT 2023
PRIMARY
EVMPD
SUB05953MIG
Created by admin on Fri Dec 15 16:20:33 GMT 2023 , Edited by admin on Fri Dec 15 16:20:33 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY