U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

2001
187
Substance Class Protein
Created
by admin
on Mon Mar 31 20:32:31 GMT 2025
Edited
by admin
on Mon Mar 31 20:32:31 GMT 2025
Protein Sub Type
Sequence Type COMPLETE
Record UNII
JGH8MYC891
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DROTRECOGIN ALFA
HSDB   MI   VANDF   WHO-DD  
Preferred Name English
DROTRECOGIN ALFA (ACTIVATED)
EMA EPAR   INN   MART.   USAN   VANDF  
INN   USAN  
Official Name English
RECOMBINANT HUMAN ACTIVATED PROTEIN C (RH-APC)
Common Name English
LY203638
Code English
DROTRECOGIN ALFA (ACTIVATED) [VANDF]
Common Name English
DROTRECOGIN ALFA (ACTIVATED) [EMA EPAR]
Common Name English
Drotrecogin alfa [WHO-DD]
Common Name English
drotrecogin alfa (activated) [INN]
Common Name English
BLOOD COAGULATION FACTOR XIV (HUMAN)
Common Name English
DROTRECOGIN ALFA (ACTIVATED) [MART.]
Common Name English
DROTRECOGIN ALFA [MI]
Common Name English
DROTRECOGIN-ALFA
Common Name English
DROTRECOGIN ALFA [HSDB]
Common Name English
ACTIVATED PROTEIN C
Common Name English
LY-203638
Code English
DROTRECOGIN ALFA (ACTIVATED), LYOPHILIZED
Common Name English
DROTRECOGIN ALFA (ACTIVATED) [USAN]
Common Name English
DROTRECOGIN ALFA ACTIVATED
Common Name English
XIGRIS
Brand Name English
DROTRECOGIN ALFA, ACTIVATED
Common Name English
DROTRECOGIN ALFA [VANDF]
Common Name English
Classification Tree Code System Code
NDF-RT N0000170930
Created by admin on Mon Mar 31 20:32:31 GMT 2025 , Edited by admin on Mon Mar 31 20:32:31 GMT 2025
LIVERTOX NBK548866
Created by admin on Mon Mar 31 20:32:31 GMT 2025 , Edited by admin on Mon Mar 31 20:32:31 GMT 2025
NDF-RT N0000175639
Created by admin on Mon Mar 31 20:32:31 GMT 2025 , Edited by admin on Mon Mar 31 20:32:31 GMT 2025
NDF-RT N0000170930
Created by admin on Mon Mar 31 20:32:31 GMT 2025 , Edited by admin on Mon Mar 31 20:32:31 GMT 2025
EMA ASSESSMENT REPORTS XIGRIS (WITHDRAWN: SEPSIS)
Created by admin on Mon Mar 31 20:32:31 GMT 2025 , Edited by admin on Mon Mar 31 20:32:31 GMT 2025
NDF-RT N0000170930
Created by admin on Mon Mar 31 20:32:31 GMT 2025 , Edited by admin on Mon Mar 31 20:32:31 GMT 2025
NCI_THESAURUS C263
Created by admin on Mon Mar 31 20:32:31 GMT 2025 , Edited by admin on Mon Mar 31 20:32:31 GMT 2025
EMA ASSESSMENT REPORTS XIGRIS (WITHDRAWN: MULTIPLE ORGANS FAILURE)
Created by admin on Mon Mar 31 20:32:31 GMT 2025 , Edited by admin on Mon Mar 31 20:32:31 GMT 2025
NDF-RT N0000170930
Created by admin on Mon Mar 31 20:32:31 GMT 2025 , Edited by admin on Mon Mar 31 20:32:31 GMT 2025
WHO-VATC QB01AD10
Created by admin on Mon Mar 31 20:32:31 GMT 2025 , Edited by admin on Mon Mar 31 20:32:31 GMT 2025
NDF-RT N0000170930
Created by admin on Mon Mar 31 20:32:31 GMT 2025 , Edited by admin on Mon Mar 31 20:32:31 GMT 2025
EU-Orphan Drug EU/3/08/565
Created by admin on Mon Mar 31 20:32:31 GMT 2025 , Edited by admin on Mon Mar 31 20:32:31 GMT 2025
NCI_THESAURUS C29726
Created by admin on Mon Mar 31 20:32:31 GMT 2025 , Edited by admin on Mon Mar 31 20:32:31 GMT 2025
WHO-ATC B01AD10
Created by admin on Mon Mar 31 20:32:31 GMT 2025 , Edited by admin on Mon Mar 31 20:32:31 GMT 2025
Code System Code Type Description
DRUG BANK
DB00055
Created by admin on Mon Mar 31 20:32:31 GMT 2025 , Edited by admin on Mon Mar 31 20:32:31 GMT 2025
PRIMARY
SMS_ID
100000090238
Created by admin on Mon Mar 31 20:32:31 GMT 2025 , Edited by admin on Mon Mar 31 20:32:31 GMT 2025
PRIMARY
INN
8090
Created by admin on Mon Mar 31 20:32:31 GMT 2025 , Edited by admin on Mon Mar 31 20:32:31 GMT 2025
PRIMARY
IUPHAR
6788
Created by admin on Mon Mar 31 20:32:31 GMT 2025 , Edited by admin on Mon Mar 31 20:32:31 GMT 2025
PRIMARY
NCI_THESAURUS
C80267
Created by admin on Mon Mar 31 20:32:31 GMT 2025 , Edited by admin on Mon Mar 31 20:32:31 GMT 2025
PRIMARY
EVMPD
SUB20025
Created by admin on Mon Mar 31 20:32:31 GMT 2025 , Edited by admin on Mon Mar 31 20:32:31 GMT 2025
PRIMARY
WIKIPEDIA
DROTRECOGIN ALFA
Created by admin on Mon Mar 31 20:32:31 GMT 2025 , Edited by admin on Mon Mar 31 20:32:31 GMT 2025
PRIMARY
RXCUI
352374
Created by admin on Mon Mar 31 20:32:31 GMT 2025 , Edited by admin on Mon Mar 31 20:32:31 GMT 2025
ALTERNATIVE
HSDB
7366
Created by admin on Mon Mar 31 20:32:31 GMT 2025 , Edited by admin on Mon Mar 31 20:32:31 GMT 2025
PRIMARY
ChEMBL
CHEMBL2109065
Created by admin on Mon Mar 31 20:32:31 GMT 2025 , Edited by admin on Mon Mar 31 20:32:31 GMT 2025
PRIMARY
FDA UNII
JGH8MYC891
Created by admin on Mon Mar 31 20:32:31 GMT 2025 , Edited by admin on Mon Mar 31 20:32:31 GMT 2025
PRIMARY
RXCUI
353106
Created by admin on Mon Mar 31 20:32:31 GMT 2025 , Edited by admin on Mon Mar 31 20:32:31 GMT 2025
PRIMARY
USAN
KK-85
Created by admin on Mon Mar 31 20:32:31 GMT 2025 , Edited by admin on Mon Mar 31 20:32:31 GMT 2025
PRIMARY
MERCK INDEX
m9265
Created by admin on Mon Mar 31 20:32:31 GMT 2025 , Edited by admin on Mon Mar 31 20:32:31 GMT 2025
PRIMARY Merck Index
MESH
C421124
Created by admin on Mon Mar 31 20:32:31 GMT 2025 , Edited by admin on Mon Mar 31 20:32:31 GMT 2025
PRIMARY
CAS
98530-76-8
Created by admin on Mon Mar 31 20:32:31 GMT 2025 , Edited by admin on Mon Mar 31 20:32:31 GMT 2025
PRIMARY
From To
1_39 1_55
1_174 1_188
1_199 1_227
2_17 2_22
2_50 2_69
2_59 2_64
2_63 2_78
2_80 2_89
2_98 2_109
2_105 2_118
2_120 2_133
1_120 2_141
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_91
N 1_156
N 1_172
N 2_97
Related Record Type Details
DROTRECOGIN ALFA (ACTIVATED)
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID SUBSTITUTION [2_71] Amount: .BETA.-HYDROXY-L-ASPARTIC ACID, ERYTHRO- GDV0MSK2SG
AMINO ACID SUBSTITUTION [2_6] [2_7] [2_14] [2_16] [2_19] [2_20] [2_25] [2_26] [2_29] .GAMMA.-CARBOXYGLUTAMIC ACID 16FQV4RZKL
AMINO_ACID_SUBSTITUTION [2_71] Amount: .BETA.-HYDROXY-L-ASPARTIC ACID, THREO- Z9Q5W0U8VW
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:ESTIMATED CHEMICAL
NIH
NCATS
PRIVACY NOTICE
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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