U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 11:04:43 GMT 2023
Edited
by admin
on Sat Dec 16 11:04:43 GMT 2023
Protein Type MONOCLONAL ANTIBODY
Protein Sub Type IGG1
Sequence Origin HUMANIZED MOUSE
Sequence Type COMPLETE
Record UNII
JEA93WJ5DG
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SOTIGALIMAB
USAN   INN  
Official Name English
SOTIGALIMAB [USAN]
Common Name English
sotigalimab [INN]
Common Name English
APX-005
Code English
APX-005M
Code English
IMMUNOGLOBULIN G1 (270-GLUTAMIC ACID, C-TERMINAL-LYSINE-CLIPPED), ANTI-(HUMAN CD40 ANTIGEN) (HUMAN-ORYCTOLAGUS CUNICULUS MONOCLONAL APX005M .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN-ORYCTOLAGUS CUNICULUS MONOCLONAL APX005M .KAPPA.-CHAIN, DIMER
Common Name English
CD40 AGONISTIC MONOCLONAL ANTIBODY APX005M
Common Name English
APX005M
Code English
Sotigalimab [WHO-DD]
Common Name English
EPI-0050
Code English
Classification Tree Code System Code
NCI_THESAURUS C133877
Created by admin on Sat Dec 16 11:04:43 GMT 2023 , Edited by admin on Sat Dec 16 11:04:43 GMT 2023
FDA ORPHAN DRUG 768220
Created by admin on Sat Dec 16 11:04:43 GMT 2023 , Edited by admin on Sat Dec 16 11:04:43 GMT 2023
FDA ORPHAN DRUG 830321
Created by admin on Sat Dec 16 11:04:43 GMT 2023 , Edited by admin on Sat Dec 16 11:04:43 GMT 2023
FDA ORPHAN DRUG 726619
Created by admin on Sat Dec 16 11:04:43 GMT 2023 , Edited by admin on Sat Dec 16 11:04:43 GMT 2023
Code System Code Type Description
CAS
2305607-45-6
Created by admin on Sat Dec 16 11:04:43 GMT 2023 , Edited by admin on Sat Dec 16 11:04:43 GMT 2023
PRIMARY
NCI_THESAURUS
C123734
Created by admin on Sat Dec 16 11:04:43 GMT 2023 , Edited by admin on Sat Dec 16 11:04:43 GMT 2023
PRIMARY
FDA UNII
JEA93WJ5DG
Created by admin on Sat Dec 16 11:04:43 GMT 2023 , Edited by admin on Sat Dec 16 11:04:43 GMT 2023
PRIMARY
USAN
JK-152
Created by admin on Sat Dec 16 11:04:43 GMT 2023 , Edited by admin on Sat Dec 16 11:04:43 GMT 2023
PRIMARY
INN
11472
Created by admin on Sat Dec 16 11:04:43 GMT 2023 , Edited by admin on Sat Dec 16 11:04:43 GMT 2023
PRIMARY
From To
1_22 1_96
1_147 1_203
1_223 3_215
1_229 2_229
1_232 2_232
1_264 1_324
1_370 1_428
2_22 2_96
2_147 2_203
2_223 4_215
2_264 2_324
2_370 2_428
3_23 3_88
3_135 3_195
4_23 4_88
4_135 4_195
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_58
N 1_300
N 2_58
N 2_300
Related Record Type Details
TARGET -> AGONIST
Agonist of the cell surface receptor CD40, with potential immunostimulatory and antineoplastic activities.
AGONIST
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL