Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C14H20Cl4N2 |
| Molecular Weight | 358.134 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 2 |
SHOW SMILES / InChI
SMILES
C[N+](C)(C)CC[N+]1(C)CC2=C(C1)C(Cl)=C(Cl)C(Cl)=C2Cl
InChI
InChIKey=IXWDUZLHWJKVPX-UHFFFAOYSA-N
InChI=1S/C14H20Cl4N2/c1-19(2,3)5-6-20(4)7-9-10(8-20)12(16)14(18)13(17)11(9)15/h5-8H2,1-4H3/q+2
| Molecular Formula | C14H20Cl4N2 |
| Molecular Weight | 358.134 |
| Charge | 2 |
| Count |
|
| Stereochemistry | MIXED |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Modulation of neuronal nicotinic acetylcholine receptors by halothane in rat cortical neurons. | 2001 Apr |
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| Reversal of acute effects of high dose morphine on lymphocyte activity by chlorisondamine. | 2001 Apr 1 |
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| Dietary soy exerts an antihypertensive effect in spontaneously hypertensive female rats. | 2001 Aug |
|
| Pharmacological dissection of vascular effects caused by activation of protease-activated receptors 1 and 2 in anesthetized rats. | 2001 Jun |
|
| Evidence that extrapancreatic GLUT2-dependent glucose sensors control glucagon secretion. | 2001 Jun |
|
| Depletion of brown fat norepinephrine content by acute cold exposure and adrenoceptor blockade. | 2001 Mar |
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| Effects of antihypertensive drugs on ultrasound production and cardiovascular responses in 15-day-old rats. | 2002 Apr 1 |
|
| Influence of cytisine on catecholamine release in isolated perfused rat adrenal glands. | 2002 Dec |
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| Rapid elevation of plasma interleukin-6 by morphine is dependent on autonomic stimulation of adrenal gland. | 2002 Jan |
|
| Isoflurane hyperalgesia is modulated by nicotinic inhibition. | 2002 Jul |
|
| Cardiovascular and behavioural components of conditioned fear to context after ganglionic and alpha-adrenergic blockade. | 2002 Jun 28 |
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| Effects of nicotine on memory impairment induced by blockade of muscarinic, nicotinic and dopamine D2 receptors in rats. | 2003 Aug 8 |
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| Effect of intravenous angiotensin II infusion on responses to hypothalamic PVN injection of bicuculline. | 2003 Dec |
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| Effect of (+/-)-epibatidine, a nicotinic agonist, on the central pathways controlling voiding function in the rat. | 2003 Jul |
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| Interaction of chlorisondamine with the neuronal nicotinic acetylcholine receptor. | 2003 Mar-Apr |
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| An endogenous cannabinoid tone attenuates cholera toxin-induced fluid accumulation in mice. | 2003 Sep |
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| Role of prostaglandin, endothelin and sympathetic nervous system on the L-NAME-induced pressor responses in spontaneously hypertensive rats. | 2003 Sep 5 |
|
| Effect of a perinatal high-salt diet on blood pressure control mechanisms in young Sprague-Dawley rats. | 2004 Apr |
|
| Adrenocorticotropin reverses hemorrhagic shock in anesthetized rats through the rapid activation of a vagal anti-inflammatory pathway. | 2004 Aug 1 |
|
| Ganglionic action of angiotensin contributes to sympathetic activity in renin-angiotensinogen transgenic mice. | 2004 Feb |
|
| The interaction between the cholinergic and dopaminergic system in learning and memory process in rats. | 2004 Jan-Jun |
|
| Mechanism of action of A-85380 in an animal model of depression. | 2004 Jul |
|
| Central but not the peripheral action of cholinergic compounds suppresses the immune system. | 2004 Mar |
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| Brain stem control of arterial pressure in chronic arterial baroreceptor-denervated rats. | 2005 Dec |
|
| Study of the interaction of chlorisondamine and chlorisondamine analogues with an epitope of the alpha-2 neuronal acetylcholine nicotinic receptor subunit. | 2005 Mar-Apr |
|
| Localization and analyses of small drug molecules in rat brain tissue sections. | 2005 Oct 15 |
|
| The effect of the cholinergic anti-inflammatory pathway on experimental colitis. | 2007 Nov |
|
| Chlorisondamine inhibits the nicotine-induced stimulation of c-fos in the pigeon brain for up to 2 weeks. | 2007 Sep |
|
| Effect of chronic IL-6 infusion on acute pressor responses to vasoconstrictors in mice. | 2007 Sep |
|
| Nicotine-activated descending facilitation on spinal NMDA-dependent reflex potentiation from pontine tegmentum in rats. | 2008 May |
|
| The effect of restraint stress on glucocorticoid receptors in mouse spleen lymphocytes: involvement of the sympathetic nervous system. | 2010 |
|
| Rat brain CYP2B induction by nicotine is persistent and does not involve nicotinic acetylcholine receptors. | 2010 Aug 12 |
|
| Increase in locomotor activity after acute administration of the nicotinic receptor agonist 3-bromocytisine in rats. | 2010 May 25 |
Sample Use Guides
In cultured dissociated mesencephalic cells of the fetal rat, chlorisondamine inhibited [3H]-dopamine release evoked by N-methyl-D-aspartate (10^-4 M), but only at high concentrations (IC50 approx. 600 microM). A high concentration of chlorisondamine (10^-3 M) had no effect on responses to quisqualate (10^-5 M) and only slightly reduced responses to kainate (10^-4 M). In adult rat hippocampal slices, chlorisondamine depressed NMDA receptor-mediated synaptically-evoked field potentials, but again only at high concentrations (10^-4-10^-3 M). Synaptic responses that were mediated by non-NMDA excitatory amino acid receptors were less affected.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 17:24:39 GMT 2023
by
admin
on
Fri Dec 15 17:24:39 GMT 2023
|
| Record UNII |
JD3M24F66I
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| Record Status |
Validated (UNII)
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| Record Version |
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-
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| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C66886
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| Code System | Code | Type | Description | ||
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7701-62-4
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JD3M24F66I
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DTXSID0048395
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CHLORISONDAMINE
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D002714
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598
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C83619
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6244
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SALT/SOLVATE -> PARENT |
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ACTIVE MOIETY |
