Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C14H20Cl4N2 |
| Molecular Weight | 358.134 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 2 |
| E/Z Centers | 0 |
| Charge | 2 |
SHOW SMILES / InChI
SMILES
C[N+](C)(C)CC[N+]1(C)CC2=C(Cl)C(Cl)=C(Cl)C(Cl)=C2C1
InChI
InChIKey=IXWDUZLHWJKVPX-UHFFFAOYSA-N
InChI=1S/C14H20Cl4N2/c1-19(2,3)5-6-20(4)7-9-10(8-20)12(16)14(18)13(17)11(9)15/h5-8H2,1-4H3/q+2
| Molecular Formula | C14H20Cl4N2 |
| Molecular Weight | 358.134 |
| Charge | 2 |
| Count |
|
| Stereochemistry | MIXED |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 2 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Lipid-enriched enteral nutrition controls the inflammatory response in murine Gram-negative sepsis. | 2010-10 |
|
| Rat brain CYP2B induction by nicotine is persistent and does not involve nicotinic acetylcholine receptors. | 2010-08-12 |
|
| Increase in locomotor activity after acute administration of the nicotinic receptor agonist 3-bromocytisine in rats. | 2010-05-25 |
|
| The effect of restraint stress on glucocorticoid receptors in mouse spleen lymphocytes: involvement of the sympathetic nervous system. | 2010 |
|
| Prenatal high salt programs enhanced sympathoadrenal activation of the cardiovascular response to restraint. | 2009-10-05 |
|
| Peripheral and central routes of administration of quaternary ammonium compound IEM-1460 are equally potent in reducing the severity of nicotine-induced seizures in mice. | 2008-07 |
|
| Nicotine-activated descending facilitation on spinal NMDA-dependent reflex potentiation from pontine tegmentum in rats. | 2008-05 |
|
| Morphine and ABT-594 (a nicotinic acetylcholine agonist) exert centrally mediated antinociception in the rat cyclophosphamide cystitis model of visceral pain. | 2008-02 |
|
| Effects of dipeptidyl peptidase iv inhibition on arterial blood pressure. | 2008-01 |
|
| Effects of kappa opioid agonists alone and in combination with cocaine on heart rate and blood pressure in conscious squirrel monkeys. | 2007-12-08 |
|
| Effect of anabasine on catecholamine secretion from the perfused rat adrenal medulla. | 2007-12 |
|
| The effect of the cholinergic anti-inflammatory pathway on experimental colitis. | 2007-11 |
|
| Nicotine-induced phosphorylation of ERK in mouse primary cortical neurons: evidence for involvement of glutamatergic signaling and CaMKII. | 2007-10 |
|
| Chlorisondamine inhibits the nicotine-induced stimulation of c-fos in the pigeon brain for up to 2 weeks. | 2007-09 |
|
| What's new in Nicotine & Tobacco Research? | 2007-09 |
|
| Effect of chronic IL-6 infusion on acute pressor responses to vasoconstrictors in mice. | 2007-09 |
|
| Effect of a diterpenoid from Salvia cinnabarina on arterial blood pressure in rats. | 2007-07 |
|
| Long- and short-term changes in the neuroimmune-endocrine parameters following inhalation exposures of F344 rats to low-dose sarin. | 2007-05 |
|
| Role of beta-endorphin, corticotropin-releasing hormone, and autonomic nervous system in mediation of the effect of chronic ethanol on natural killer cell cytolytic activity. | 2006-10 |
|
| Intracellular cGMP may promote Ca2+-dependent and Ca2+-independent release of catecholamines from sympathetic nerve terminals. | 2006-08 |
|
| CCCP enhances catecholamine release from the perfused rat adrenal medulla. | 2006-07-30 |
|
| Untranslated region-dependent exclusive expression of high-sensitivity subforms of alpha4beta2 and alpha3beta2 nicotinic acetylcholine receptors. | 2006-07 |
|
| Activation of the cholinergic anti-inflammatory pathway reduces NF-kappab activation, blunts TNF-alpha production, and protects againts splanchic artery occlusion shock. | 2006-05 |
|
| Mechanisms and significance of the increased brain uptake of tryptophan. | 2005-12 |
|
| Brain stem control of arterial pressure in chronic arterial baroreceptor-denervated rats. | 2005-12 |
|
| Localization and analyses of small drug molecules in rat brain tissue sections. | 2005-10-15 |
|
| The interaction between the cholinergic and dopaminergic system in learning and memory process in rats. | 2005-06-30 |
|
| Evaluation in rats and primates of [11C]-mecamylamine, a potential nicotinic acetylcholine receptor radioligand for positron emission tomography. | 2005-05 |
|
| Study of the interaction of chlorisondamine and chlorisondamine analogues with an epitope of the alpha-2 neuronal acetylcholine nicotinic receptor subunit. | 2005-04-13 |
|
| ABT-594 (a nicotinic acetylcholine agonist): anti-allodynia in a rat chemotherapy-induced pain model. | 2005-02-10 |
|
| Vasodilatation of the hindquarters induced by antagonism of GABA(A) receptors in the freely moving rat. | 2005-02 |
|
| Direct tissue analysis of phospholipids in rat brain using MALDI-TOFMS and MALDI-ion mobility-TOFMS. | 2005-02 |
|
| Supraspinal and systemic administration of the nicotinic-cholinergic agonist (+/-)-epibatidine has inhibitory effects on C-fiber reflexes in the rat. | 2004-12-15 |
|
| Salsolinol, an antagonist of prolactoliberine, induces an increase in plasma catecholamine levels in the rat. | 2004-09-30 |
|
| Adrenocorticotropin reverses hemorrhagic shock in anesthetized rats through the rapid activation of a vagal anti-inflammatory pathway. | 2004-08-01 |
|
| Mechanism of action of A-85380 in an animal model of depression. | 2004-07 |
|
| Effect of a perinatal high-salt diet on blood pressure control mechanisms in young Sprague-Dawley rats. | 2004-04 |
|
| Central but not the peripheral action of cholinergic compounds suppresses the immune system. | 2004-03 |
|
| Ganglionic action of angiotensin contributes to sympathetic activity in renin-angiotensinogen transgenic mice. | 2004-02 |
|
| Cardiovascular effects of nicotine, chlorisondamine, and mecamylamine in the pigeon. | 2004-01 |
|
| Effect of intravenous angiotensin II infusion on responses to hypothalamic PVN injection of bicuculline. | 2003-12 |
|
| Role of prostaglandin, endothelin and sympathetic nervous system on the L-NAME-induced pressor responses in spontaneously hypertensive rats. | 2003-09-05 |
|
| An endogenous cannabinoid tone attenuates cholera toxin-induced fluid accumulation in mice. | 2003-09 |
|
| Catecholamine secretory vesicle stimulus-transcription coupling in vivo. Demonstration by a novel transgenic promoter/photoprotein reporter and inhibition of secretion and transcription by the chromogranin A fragment catestatin. | 2003-08-22 |
|
| Effects of nicotine on memory impairment induced by blockade of muscarinic, nicotinic and dopamine D2 receptors in rats. | 2003-08-08 |
|
| Effect of (+/-)-epibatidine, a nicotinic agonist, on the central pathways controlling voiding function in the rat. | 2003-07 |
|
| Different vascular responsiveness to angiotensin II in two normotensive rat strains. | 2003-06 |
|
| Peripheral and central sites of action for A-85380 in the spinal nerve ligation model of neuropathic pain. | 2003-06 |
|
| The role of ionotropic receptors of glutaminic acid in cardiovascular system. A. The influence of ionotropic receptor NMDA agonist - 1R,3R-ACPD and antagonist - DL-AP7 on the systemic pressure in rats. | 2003-06 |
|
| Interaction of chlorisondamine with the neuronal nicotinic acetylcholine receptor. | 2003-04-29 |
Sample Use Guides
In cultured dissociated mesencephalic cells of the fetal rat, chlorisondamine inhibited [3H]-dopamine release evoked by N-methyl-D-aspartate (10^-4 M), but only at high concentrations (IC50 approx. 600 microM). A high concentration of chlorisondamine (10^-3 M) had no effect on responses to quisqualate (10^-5 M) and only slightly reduced responses to kainate (10^-4 M). In adult rat hippocampal slices, chlorisondamine depressed NMDA receptor-mediated synaptically-evoked field potentials, but again only at high concentrations (10^-4-10^-3 M). Synaptic responses that were mediated by non-NMDA excitatory amino acid receptors were less affected.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:46:01 GMT 2025
by
admin
on
Mon Mar 31 18:46:01 GMT 2025
|
| Record UNII |
JD3M24F66I
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Preferred Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
|
NCI_THESAURUS |
C66886
Created by
admin on Mon Mar 31 18:46:01 GMT 2025 , Edited by admin on Mon Mar 31 18:46:01 GMT 2025
|
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
7701-62-4
Created by
admin on Mon Mar 31 18:46:01 GMT 2025 , Edited by admin on Mon Mar 31 18:46:01 GMT 2025
|
PRIMARY | |||
|
JD3M24F66I
Created by
admin on Mon Mar 31 18:46:01 GMT 2025 , Edited by admin on Mon Mar 31 18:46:01 GMT 2025
|
PRIMARY | |||
|
DTXSID0048395
Created by
admin on Mon Mar 31 18:46:01 GMT 2025 , Edited by admin on Mon Mar 31 18:46:01 GMT 2025
|
PRIMARY | |||
|
CHLORISONDAMINE
Created by
admin on Mon Mar 31 18:46:01 GMT 2025 , Edited by admin on Mon Mar 31 18:46:01 GMT 2025
|
PRIMARY | |||
|
D002714
Created by
admin on Mon Mar 31 18:46:01 GMT 2025 , Edited by admin on Mon Mar 31 18:46:01 GMT 2025
|
PRIMARY | |||
|
598
Created by
admin on Mon Mar 31 18:46:01 GMT 2025 , Edited by admin on Mon Mar 31 18:46:01 GMT 2025
|
PRIMARY | |||
|
C83619
Created by
admin on Mon Mar 31 18:46:01 GMT 2025 , Edited by admin on Mon Mar 31 18:46:01 GMT 2025
|
PRIMARY | |||
|
6244
Created by
admin on Mon Mar 31 18:46:01 GMT 2025 , Edited by admin on Mon Mar 31 18:46:01 GMT 2025
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
SALT/SOLVATE -> PARENT |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
ACTIVE MOIETY |
