Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C20H28N2O |
| Molecular Weight | 312.4491 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C(CN1CCCCC1)C#CC2=CC(CN3CCOCC3)=CC=C2
InChI
InChIKey=HDRIBIYPLKZUDQ-UHFFFAOYSA-N
InChI=1S/C20H28N2O/c1-3-10-21(11-4-1)12-5-2-7-19-8-6-9-20(17-19)18-22-13-15-23-16-14-22/h6,8-9,17H,1,3-5,10-16,18H2
| Molecular Formula | C20H28N2O |
| Molecular Weight | 312.4491 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
JNJ-10181457 is a histamine H3 receptor antagonist, which was developed by Johnson & Johnson. Selective blockade of histamine H3 receptors might have therapeutic utility for the treatment of working memory deficits and learning disorders, especially those in which ACh neurotransmission is compromised.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Radiosynthesis and biodistribution of a histamine H3 receptor antagonist 4-[3-(4-piperidin-1-yl-but-1-ynyl)-[11C]benzyl]-morpholine: evaluation of a potential PET ligand. | 2006 Aug |
|
| JNJ-10181457, a selective non-imidazole histamine H(3) receptor antagonist, normalizes acetylcholine neurotransmission and has efficacy in translational rat models of cognition. | 2009 Jun |
|
| Diamine-based human histamine H3 receptor antagonists: (4-aminobutyn-1-yl)benzylamines. | 2009 Oct |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:36:14 GMT 2023
by
admin
on
Sat Dec 16 08:36:14 GMT 2023
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| Record UNII |
JD270971QC
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| Record Status |
Validated (UNII)
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544707-19-9
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1188547-18-3
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JD270971QC
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