ORNITHINE ASPARTATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C5H12N2O2.C4H7NO4
Molecular Weight	265.2637
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NCCC[C@H](N)C(O)=O.N[C@@H](CC(O)=O)C(O)=O

InChI

InChIKey=IXUZXIMQZIMPSQ-ZBRNBAAYSA-N

InChI=1S/C5H12N2O2.C4H7NO4/c6-3-1-2-4(7)5(8)9;5-2(4(8)9)1-3(6)7/h4H,1-3,6-7H2,(H,8,9);2H,1,5H2,(H,6,7)(H,8,9)/t4-;2-/m00/s1

HIDE SMILES / InChI

Molecular Formula	C4H7NO4
Molecular Weight	133.1027
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	C5H12N2O2
Molecular Weight	132.161
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: http://www.hmdb.ca/metabolites/HMDB00214
Curator's Comment: description was created based on several sources, including https://www.drugbank.ca/drugs/DB00129

Ornithine is an amino acid produced in the urea cycle by the splitting off of urea from arginine. It is a central part of the urea cycle, which allows for the disposal of excess nitrogen. Ornithine is also a precursor of citrulline and arginine. Arginine stimulates the pituitary release of growth hormone. Burns or other injuries affect the state of arginine in tissues throughout the body. As de novo synthesis of arginine during these conditions is usually not sufficient for normal immune function, nor for normal protein synthesis, ornithine may have immunomodulatory and wound-healing activities under these conditions (by virtue of its metabolism to arginine).

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
G-protein coupled receptor family C group 6 member A 22 Target ID: Q5T6X5 Gene ID: 222545.0 Gene Symbol: GPRC6A Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/15576628	Agonist 2678		112.0 µM [EC50]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Dietary shortage or imbalance 9 Sources: https://www.drugbank.ca/drugs/DB00129	Primary		Approved 8429	L-Ornithine Approved Use Used for nutritional supplementation, also for treating dietary shortage or imbalance.

PubMed

Title	Date	PubMed
[Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome].	2001	11462710
Cancer chemopreventive activities of S-3-1, a synthetic derivative of danshinone.	2001	11355772
Diagnosis of Japanese patients with HHH syndrome by molecular genetic analysis: a common mutation, R179X.	2001	11355015
Effect of exercise on the metabolism of vitamin B6 and some PLP-dependent enzymes in young rats fed a restricted vitamin B6 diet.	2001 Apr	11508701
Effects of amino acid and trace element supplementation on pneumocandin production by Glarea lozoyensis: impact on titer, analogue levels, and the identification of new analogues of pneumocandin B(0).	2001 Apr	11464269
Analysis of amino acids in human serum by isocratic reversed-phase high-performance liquid chromatography with electrochemical detection.	2001 Apr 13	11355826
Derivatization and chromatographic behavior of the o-phthaldialdehyde amino acid derivatives obtained with various SH-group-containing additives.	2001 Apr 13	11355824
Hyperornithinemia associated with gyrate atrophy of the choroid and retina in a child with myopia.	2001 Aug	11521006
Intrahepatic amino acid and glucose metabolism in a D-galactosamine-induced rat liver failure model.	2001 Aug	11481621
The potential mechanism for glutamine-induced collagen biosynthesis in cultured human skin fibroblasts.	2001 Aug	11470441
Plasma levels of amino acids and hypermetabolism in patients with chronic obstructive pulmonary disease.	2001 Feb	11240335
Biogenic amine production by Lactobacillus.	2001 Feb	11168717
Macrophage arginase promotes tumor cell growth and suppresses nitric oxide-mediated tumor cytotoxicity.	2001 Feb 1	11221839
Transforming growth factor-beta(1) stimulates L-arginine transport and metabolism in vascular smooth muscle cells: role in polyamine and collagen synthesis.	2001 Feb 27	11222476
Determination of amino acids by ion-exchange chromatography on filter paper spotted blood samples stored at different temperatures and for different periods: comparison with capillary and venous blood.	2001 Jul	11522278
Burkholderia ambifaria sp. nov., a novel member of the Burkholderia cepacia complex including biocontrol and cystic fibrosis-related isolates.	2001 Jul	11491349
Urea flux in beef steers: effects of forage species and nitrogen fertilization.	2001 Jul	11465382
Ornithine aminotransferase messenger RNA expression and enzymatic activity in fetal porcine intestine.	2001 Jul	11420426
Analysis of differentially expressed genes in human hepatocellular carcinoma using suppression subtractive hybridization.	2001 Jul 20	11461082
Antifungal activity of three spermidine conjugates.	2001 Jul 24	11470370
Structural requirements for conserved arginine of parathyroid hormone.	2001 Jul 31	11467957
Experimental chronic arthritis and granulomatous inflammation induced by bifidobacterium cell walls.	2001 Jul-Aug	11439164
Metabolic effects of arginine addition to the enteral feeding of critically ill patients.	2001 Jul-Aug	11434648
Methohexital affects neutrophil (PMN) dynamic free amino acid pool and immune functions in vitro.	2001 Jun	11412289
HHH syndrome associated with callosal agenesis and disordered neuronal migration.	2001 Jun	11409836
Regulation of loblolly pine (Pinus taeda L.) arginase in developing seedling tissue during germination and post-germinative growth.	2001 Mar	11414614
Effects of charged amino acids at b and c heptad positions on specificity and stability of four-chain coiled coils.	2001 Mar	11344331
Chromatographic quantification of argpyrimidine, a methylglyoxal-derived product in tissue proteins: comparison with pentosidine.	2001 Mar	11237339
Alterations in arginine metabolic enzymes in trauma.	2001 Mar	11236905
In vivo confocal Raman microspectroscopy of the skin: noninvasive determination of molecular concentration profiles.	2001 Mar	11231318
Arginase I expression and activity in human mononuclear cells after injury.	2001 Mar	11224628
Rat colon ornithine and arginine metabolism: coordinated effects after proliferative stimuli.	2001 Mar	11171621
Gastrectomized patients are in a state of chronic protein malnutrition analyses of 23 amino acids.	2001 Mar-Apr	11379360
Facilitatory and neurotoxic effects of intravitreal ornithine on the electroretinographic responses of albino rats.	2001 Mar-Apr	11244354
Significance of arginase and ornithine in malignant tumors of the human skin.	2001 May	11329531
Expression, purification, and characterization of human type II arginase.	2001 May 1	11370664
Biogenic amines in wines: role of lactic acid bacteria.	2001 May 15	11356560
Crystallographic studies on endothelial nitric oxide synthase complexed with nitric oxide and mechanism-based inhibitors.	2001 May 8	11331003
SREA is involved in regulation of siderophore biosynthesis, utilization and uptake in Aspergillus nidulans.	2001 Sep	11555288
Clinical and molecular findings in hyperornithinemia-hyperammonemia-homocitrullinuria syndrome.	2001 Sep 11	11552031
Interstrand side chain--side chain interactions in a designed beta-hairpin: significance of both lateral and diagonal pairings.	2001 Sep 12	11535071
Allosteric control of the oligomerization of carbamoyl phosphate synthetase from Escherichia coli.	2001 Sep 18	11551199

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Measurement of Ca2+-dependent chloride currents in Xenopus laevis oocytes facilitated the deorphanization of human family C G-protein-coupled receptor hGPRC6A/homologous goldfish 5.24 receptor chimeric construct (h6A/5.24) and identification of L-amino acids as agonists. The most active agonists were L-Arg, L-Lys, and L-ornithine, suggesting that these may function as endogenous signaling molecules (only L-Arg, L-Lys, and L-ornithine were able to activate h6A/5.24 at 10 uM concentration).

Substance Class	Chemical Created by `admin` on `Fri Dec 15 21:17:47 GMT 2023` Edited by `admin` on `Fri Dec 15 21:17:47 GMT 2023`
Record UNII	JA08T3B97O
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ORNITHINE ASPARTATE

Common Name

English

L-ORNITHINE, L-ASPARTATE (1:1)

Common Name

English

L-ORNITHINE-L-ASPARTATE (SALT)

Common Name

English

L-ORNITHINE L-ASPARTATE

Common Name

English

ORPARAN

Brand Name

English

Ornithine aspartate [WHO-DD]

Common Name

English

L-ASPARTIC ACID, COMPD. WITH L-ORNITHINE (1:1)

Common Name

English

ORNITHINE, L-, L-ASPARTATE (1:1)

Common Name

English

ORMETA

Brand Name

English

ORNITHINE L-FORM ASPARTATE [MI]

Common Name

English

RUIGAN

Brand Name

English

ASPARTIC ACID COMPD. WITH ORNITHINE

Systematic Name

English

ASPARTIC ACID, L-, COMPD. WITH L-ORNITHINE (1:1)

Common Name

English

ORNITHINE L-FORM ASPARTATE

Common Name

English

HEPAMERZ

Brand Name

English

L-ORNITHINE-L-ASPARTATE

Common Name

English

LOLA

Common Name

English

Classification Tree Code System Code

DSLD

4334 (Number of products:33)