Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C17H23NO.ClH |
| Molecular Weight | 293.832 |
| Optical Activity | ( + ) |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.C[C@@H]1[C@@H]2CC3=CC=C(O)C=C3[C@@]1(C)CCN2CC=C
InChI
InChIKey=ZTGMHFIGNYXMJV-XSCGHNKWSA-N
InChI=1S/C17H23NO.ClH/c1-4-8-18-9-7-17(3)12(2)16(18)10-13-5-6-14(19)11-15(13)17;/h4-6,11-12,16,19H,1,7-10H2,2-3H3;1H/t12-,16+,17+;/m1./s1
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C17H23NO |
| Molecular Weight | 257.3706 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
DescriptionCurator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/7957624 |
https://www.ncbi.nlm.nih.gov/pubmed/23139844
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/7957624 |
https://www.ncbi.nlm.nih.gov/pubmed/23139844
(+)-SKF-10,047 is a sigma-opioid receptor agonist. (+)-SKF-10,047 is distinct from its (-)-enantiomer in binding pattern and associated behavioural effects. (+)-SKF-10,047 stress-induced motor suppression, while its (-)-optical isomer was inactive. Besides activation of sigma-1 receptor, (+)-SKF-10,047 is inhibitor of Na(V)1.2 and Na(V)1.4 channels.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Sigma-1 receptor agonists directly inhibit Nav1.2/1.4 channels. | 2012 |
|
| Effects of (+)SKF 10047, a sigma-1 selective agonist, on isolation-induced aggression in male mice. | 2006-11 |
|
| SKF-10,047 reverses stress-induced motor suppression: interaction with dopaminergic system. | 1994-07-21 |
|
| Agonist and antagonist actions of morphine-like drugs on the guinea-pig isolated ileum. | 1966-09 |
Sample Use Guides
To evaluate effect of (+)-SKF-10,047 on conditioned fear stress, the drug was administered subcutaneously at 20 min before motility was measured in the test trial. (+)-SKF-10,047 (3 and 6 mg/kg) dose-dependently attenuated the conditioned fear stress.
Route of Administration:
Other
| Substance Class |
Chemical
Created
by
admin
on
Edited
Wed Apr 02 05:17:19 GMT 2025
by
admin
on
Wed Apr 02 05:17:19 GMT 2025
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| Record UNII |
J9S5L9NLC3
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| Record Status |
Validated (UNII)
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| Record Version |
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J9S5L9NLC3
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133005-41-1
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13286169
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DTXSID70474678
Created by
admin on Wed Apr 02 05:17:19 GMT 2025 , Edited by admin on Wed Apr 02 05:17:19 GMT 2025
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ENANTIOMER -> ENANTIOMER |
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PARENT -> SALT/SOLVATE |
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ACTIVE MOIETY |
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