FLUTROLINE

Details

Stereochemistry	RACEMIC
Molecular Formula	C27H25F3N2O
Molecular Weight	450.4954
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(CCCN1CCC2=C(C1)C3=C(C=CC(F)=C3)N2C4=CC=C(F)C=C4)C5=CC=C(F)C=C5

InChI

InChIKey=OYGDOCFZQVGFIP-UHFFFAOYSA-N

InChI=1S/C27H25F3N2O/c28-19-5-3-18(4-6-19)27(33)2-1-14-31-15-13-26-24(17-31)23-16-21(30)9-12-25(23)32(26)22-10-7-20(29)8-11-22/h3-12,16,27,33H,1-2,13-15,17H2

HIDE SMILES / InChI

Molecular Formula	C27H25F3N2O
Molecular Weight	450.4954
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6141186 | https://www.ncbi.nlm.nih.gov/pubmed/6129266

Flutroline, an antipsychotic drug that was studied to treat patients with schizophrenia. Clinical trials have shown that the drug was a safe, effective, and 20 mg and above offered the best potential for optimal clinical effectiveness. However, information about the further development of this drug is not available.

Approval Year

PubMed

Title	Date	PubMed
Flutroline in the treatment of the schizophrenic patient.	1982 Oct	6129266
The prolactin response to flutroline hydrochloride in schizophrenic patients.	1983 Nov-Dec	6141186
[Indoles. 10. Synthesis, structure and D2-affinity of beta-carboline analogs of flutroline].	1993 Dec	7907210

Sample Use Guides

In Vivo Use Guide

in single daily dosages of 1, 5, 10, 20, and 100 mg to 48 hospitalized schizophrenic patients over a period of four weeks

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:50:14 UTC 2023` Edited by `admin` on `Sat Dec 16 17:50:14 UTC 2023`
Record UNII	J922111J7P
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

FLUTROLINE

Official Name

English

CP-36,584

Code

English

(±)-8-FLUORO-.ALPHA.,5-BIS(P-FLUOROPHENYL)-1,3,4,5-TETRAHYDRO-2H-PYRIDO(4,3-B)INDOLE-2-BUTANOL

Common Name

English

flutroline [INN]

Common Name

English

2H-PYRIDO(4,3-B)INDOLE-2-BUTANOL, 8-FLUORO-.ALPHA.,5-BIS(4-FLUOROPHENYL)-1,3,4,5-TETRAHYDRO-, (±)-

Systematic Name

English

CP-36584

Code

English

Flutroline [WHO-DD]

Common Name

English

FLUTROLINE [USAN]

Common Name

English

Code System Code Type Description

EVMPD

SUB07766MIG