Stereochemistry | ACHIRAL |
Molecular Formula | C22H22ClN5O2S |
Molecular Weight | 455.96 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=NN=C2CN=C(C3=C(SC(CCC(=O)N4CCOCC4)=C3)N12)C5=C(Cl)C=CC=C5
InChI
InChIKey=JGPJQFOROWSRRS-UHFFFAOYSA-N
InChI=1S/C22H22ClN5O2S/c1-14-25-26-19-13-24-21(16-4-2-3-5-18(16)23)17-12-15(31-22(17)28(14)19)6-7-20(29)27-8-10-30-11-9-27/h2-5,12H,6-11,13H2,1H3
Molecular Formula | C22H22ClN5O2S |
Molecular Weight | 455.96 |
Charge | 0 |
Count |
MOL RATIO
1 MOL RATIO (average) |
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
APAFANT is a platelet activating factor receptor (PAF-R) antagonist shown to have anticancer and cell differentiation effects. APAFANT has been found to be a specific PAF-R antagonist in pulmonary vasculature and when administered intratracheally in rats. APAFANT was observed to decrease lung nuclear factor-κB (NF-κB) activation, myeloperoxidase activity, and lavage neutrophil numbers. It has been shown to be a cytodifferentiating agent in murine erythroleukemia cells in vitro.
CNS Activity
Originator
Approval Year
PubMed
Patents
Sample Use Guides
The ATRA-sensitive APL cell line NB4 and ATRA-resistant NB4 subclones NB4-007-6 and NB4-MR4 (gift of C Gambacorti-Passerini and WH Miller, respectively) were used for activity evaluation. Cells (1x105/ml) were incubated for 5 days without and with 1mkM WEB-2086 (APAFANT) or 1mM ATRA. Cell densities were evaluated daily.