Details
Stereochemistry | ACHIRAL |
Molecular Formula | C22H24ClN5O |
Molecular Weight | 409.912 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CN(C)CCNC(=O)CN1C2=CC=C(Cl)C=C2C3=C1N=C4C=C(C)C(C)=CC4=N3
InChI
InChIKey=PDNNUMNEXITLCZ-UHFFFAOYSA-N
InChI=1S/C22H24ClN5O/c1-13-9-17-18(10-14(13)2)26-22-21(25-17)16-11-15(23)5-6-19(16)28(22)12-20(29)24-7-8-27(3)4/h5-6,9-11H,7-8,12H2,1-4H3,(H,24,29)
Molecular Formula | C22H24ClN5O |
Molecular Weight | 409.912 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Rabeximod is an indolo[2,3-b]quinoxaline derivative patented by OxyPharma AB as anti-inflammatory agent useful for the treatment of autoimmune disease. Rabeximod impaired monocyte differentiation into monocyte-derived dendritic cells and pro-inflammatory allostimulated macrophages. Monocyte-derived dendritic cells that were treated with Rabeximod resulted in a significant decrease in their ability to pinocytose antigens, while no effect was exerted by the drug on the ability of allostimulated macrophages and anti-inflammatory macrophages to phagocytose. Rabeximod reduces the severity of arthritis in rodent models of rheumatoid arthritis and multiple sclerosis. Rabeximod efficiently prevented arthritis during the time window when TLR2 or TLR4 ligands activate inflammatory macrophages.
Approval Year
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 18:10:22 GMT 2023
by
admin
on
Fri Dec 15 18:10:22 GMT 2023
|
Record UNII |
J4D3K58W3Z
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Official Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Systematic Name | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
NCI_THESAURUS |
C308
Created by
admin on Fri Dec 15 18:10:22 GMT 2023 , Edited by admin on Fri Dec 15 18:10:22 GMT 2023
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
J4D3K58W3Z
Created by
admin on Fri Dec 15 18:10:22 GMT 2023 , Edited by admin on Fri Dec 15 18:10:22 GMT 2023
|
PRIMARY | |||
|
56841552
Created by
admin on Fri Dec 15 18:10:22 GMT 2023 , Edited by admin on Fri Dec 15 18:10:22 GMT 2023
|
PRIMARY | |||
|
872178-65-9
Created by
admin on Fri Dec 15 18:10:22 GMT 2023 , Edited by admin on Fri Dec 15 18:10:22 GMT 2023
|
PRIMARY | |||
|
DTXSID701007428
Created by
admin on Fri Dec 15 18:10:22 GMT 2023 , Edited by admin on Fri Dec 15 18:10:22 GMT 2023
|
PRIMARY | |||
|
300000027018
Created by
admin on Fri Dec 15 18:10:22 GMT 2023 , Edited by admin on Fri Dec 15 18:10:22 GMT 2023
|
PRIMARY | |||
|
8866
Created by
admin on Fri Dec 15 18:10:22 GMT 2023 , Edited by admin on Fri Dec 15 18:10:22 GMT 2023
|
PRIMARY | |||
|
C152136
Created by
admin on Fri Dec 15 18:10:22 GMT 2023 , Edited by admin on Fri Dec 15 18:10:22 GMT 2023
|
PRIMARY | |||
|
DB05772
Created by
admin on Fri Dec 15 18:10:22 GMT 2023 , Edited by admin on Fri Dec 15 18:10:22 GMT 2023
|
PRIMARY |
Related Record | Type | Details | ||
---|---|---|---|---|
|
ACTIVE MOIETY |
|