ASOCAINOL

Possibly Marketed Outside US

Details

Stereochemistry	RACEMIC
Molecular Formula	C27H31NO3
Molecular Weight	417.5399
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC2=C(CCN(C)C(CCC3=CC=CC=C3)CC4=CC=C(OC)C(O)=C24)C=C1

InChI

InChIKey=IORHSKBXWWSQME-UHFFFAOYSA-N

InChI=1S/C27H31NO3/c1-28-16-15-20-10-13-23(30-2)18-24(20)26-21(11-14-25(31-3)27(26)29)17-22(28)12-9-19-7-5-4-6-8-19/h4-8,10-11,13-14,18,22,29H,9,12,15-17H2,1-3H3

HIDE SMILES / InChI

Molecular Formula	C27H31NO3
Molecular Weight	417.5399
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1328897 | https://www.ncbi.nlm.nih.gov/pubmed/8297425 | https://www.ncbi.nlm.nih.gov/pubmed/6084758 | https://www.ncbi.nlm.nih.gov/pubmed/3566851

Asocainol is a rather efficient antiarrhythmic agent that has the effects of both class Ia and class IV antiarrhythmic drugs. Asocainol interfere with the sodium channel and lengthens the action potential. Besides that, Asocainol decreases conduction through the AV node, and shorten phase two (the plateau) of the cardiac action potential. Asocainol reduce the contractility of the heart, so may be inappropriate in heart failure. Asocainol is an effective antiarrhythmic agent in a variety of animal arrhythmia models and species.

Approval Year

PubMed

Title	Date	PubMed

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:57:23 GMT 2023` Edited by `admin` on `Fri Dec 15 16:57:23 GMT 2023`
Record UNII	J40338OKKT
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ASOCAINOL

Official Name

English

asocainol [INN]

Common Name

English

(±)-6,7,8,9-TETRAHYDRO-2,12-DIMETHOXY-7-METHYL-6-PHENETHYL-5H-DIBENZ(D,F)AZONIN-1-OL

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C47793