YTTRIUM Y-90 EPRATUZUMAB TETRAXETAN

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Description

YTTRIUM Y-90 (YTRACIS®, YTTRIGA®) is a radioactive form of the chemical element yttrium. It is used for radiolabelling other medicines. An example of its use is the treatment of some type of tumors, where the radiolabelled medicine carries the radioactivity to the site of a tumor to destroy the tumor cells.

Approval Year

Substance Class	Protein
Protein Type	MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	J36232195E
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

YTTRIUM Y 90 EPRATUZUMAB TETRAXETAN

Preferred Name

English

YTTRIUM Y-90 EPRATUZUMAB TETRAXETAN

Common Name

English

90Y-EPRATUZUMAB

Common Name

English

(SUP 90)Y-DOTA-HLL2

Common Name

English

S9S0Y-DOTA-HLL2

Code

English

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Classification Tree

Code System

Code

Radioconjugate

NCI_THESAURUS

C1511

Antineoplastic Agent

NCI_THESAURUS

C129819

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Code System

Code

Type

Description

EVMPD

SUB129631

PRIMARY

MERCK INDEX

m4957

PRIMARY

Merck Index

NCI_THESAURUS

C2582

PRIMARY

ChEMBL

CHEMBL2108666

PRIMARY

CAS

501423-25-2

PRIMARY

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Subunit 0

Subunit 1

Subunit 2

Subunit 3

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From	To
1_22	1_96
1_143	1_199
1_219	3_219
1_225	2_225
1_228	2_228

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Related Record

Type

Details


					7X6143A60Y

EPRATUZUMAB-CYS-TESIRINE

PARENT -> DERIVATIVE

Comments:

test

Amount:


					3062P60MH9

DERIVATIVE -> PARENT

Comments:

test

Amount:


					RCH7C9TW12

B-CELL RECEPTOR CD22

TARGET -> INHIBITOR


					J36232195E

YTTRIUM Y-90 EPRATUZUMAB TETRAXETAN

PARENT -> DERIVATIVE

Amount:

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Related Record

Type

Details


					433ME2ATHW

YTTRIUM Y-90 CATION

ACTIVE MOIETY


					J36232195E

YTTRIUM Y-90 EPRATUZUMAB TETRAXETAN

ACTIVE MOIETY

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Structural Modifications

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Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
FRAGMENT			LYSINE		LYSINE-DOTA	KTZ0L57AI1
MOIETY			LYSINE		YTTRIUM Y-90 CATION	433ME2ATHW

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Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL	ESTIMATED C6520H10026N1734O2036S42
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL	ESTIMATED 147000 Da (average)

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