Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C17H26N4O6S |
| Molecular Weight | 414.477 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)(C)NC[C@@H](COC1=NSN=C1N2CCOCC2)OC(=O)\C=C/C(O)=O
InChI
InChIKey=MGIAXRFZDNBKRF-RXNFCKPNSA-N
InChI=1S/C17H26N4O6S/c1-17(2,3)18-10-12(27-14(24)5-4-13(22)23)11-26-16-15(19-28-20-16)21-6-8-25-9-7-21/h4-5,12,18H,6-11H2,1-3H3,(H,22,23)/b5-4-/t12-/m0/s1
| Molecular Formula | C17H26N4O6S |
| Molecular Weight | 414.477 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 1 |
| Optical Activity | UNSPECIFIED |
Timolol maleate (ISTALOL) is a non-selective beta-adrenergic receptor
blocking agent. Timolol maleate is a beta1 and beta2 (non-selective) adrenergic receptor blocking agent that does not have significant intrinsic sympathomimetic, direct myocardial depressant, or local anesthetic (membrane-stabilizing) activity. In its opthalmic form, Timolol maleate, is used to treat open-angle and occasionally secondary glaucoma. Timolol maleate, when applied topically to the eye, has the action of reducing elevated, as well as normal, intraocular pressure, whether or not accompanied by glaucoma. Elevated intraocular pressure is a major risk factor in the pathogenesis of glaucomatous visual field loss and optic nerve damage. Timolol maleate ester is a Timolol maleate specified impurity E [EP]. Timolol impurities are used for ANDA filling/DMF filling and genotoxic study.
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 10:07:08 UTC 2023
by
admin
on
Sat Dec 16 10:07:08 UTC 2023
|
| Record UNII |
J2V3WF497E
|
| Record Status |
Validated (UNII)
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| Record Version |
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-
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Systematic Name | English |
| Code System | Code | Type | Description | ||
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10112466
Created by
admin on Sat Dec 16 10:07:08 UTC 2023 , Edited by admin on Sat Dec 16 10:07:08 UTC 2023
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PRIMARY | |||
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J2V3WF497E
Created by
admin on Sat Dec 16 10:07:08 UTC 2023 , Edited by admin on Sat Dec 16 10:07:08 UTC 2023
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1026075-53-5
Created by
admin on Sat Dec 16 10:07:08 UTC 2023 , Edited by admin on Sat Dec 16 10:07:08 UTC 2023
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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PARENT -> IMPURITY |
not more than twice the area of the principal peak in the chromatogram obtained with reference solution (a)
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
|
