Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C17H26N4O6S |
| Molecular Weight | 414.477 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)(C)NC[C@@H](COC1=NSN=C1N2CCOCC2)OC(=O)\C=C/C(O)=O
InChI
InChIKey=MGIAXRFZDNBKRF-RXNFCKPNSA-N
InChI=1S/C17H26N4O6S/c1-17(2,3)18-10-12(27-14(24)5-4-13(22)23)11-26-16-15(19-28-20-16)21-6-8-25-9-7-21/h4-5,12,18H,6-11H2,1-3H3,(H,22,23)/b5-4-/t12-/m0/s1
| Molecular Formula | C17H26N4O6S |
| Molecular Weight | 414.477 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 1 |
| Optical Activity | UNSPECIFIED |
Timolol maleate (ISTALOL) is a non-selective beta-adrenergic receptor
blocking agent. Timolol maleate is a beta1 and beta2 (non-selective) adrenergic receptor blocking agent that does not have significant intrinsic sympathomimetic, direct myocardial depressant, or local anesthetic (membrane-stabilizing) activity. In its opthalmic form, Timolol maleate, is used to treat open-angle and occasionally secondary glaucoma. Timolol maleate, when applied topically to the eye, has the action of reducing elevated, as well as normal, intraocular pressure, whether or not accompanied by glaucoma. Elevated intraocular pressure is a major risk factor in the pathogenesis of glaucomatous visual field loss and optic nerve damage. Timolol maleate ester is a Timolol maleate specified impurity E [EP]. Timolol impurities are used for ANDA filling/DMF filling and genotoxic study.
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 23:03:03 GMT 2025
by
admin
on
Mon Mar 31 23:03:03 GMT 2025
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| Record UNII |
J2V3WF497E
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| Record Status |
Validated (UNII)
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| Record Version |
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10112466
Created by
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J2V3WF497E
Created by
admin on Mon Mar 31 23:03:03 GMT 2025 , Edited by admin on Mon Mar 31 23:03:03 GMT 2025
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1026075-53-5
Created by
admin on Mon Mar 31 23:03:03 GMT 2025 , Edited by admin on Mon Mar 31 23:03:03 GMT 2025
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| Related Record | Type | Details | ||
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PARENT -> IMPURITY |
