CP-31398

COC1=CC=C(\C=C\C2=NC3=CC=CC=C3C(NCCCN(C)C)=N2)C=C1

InChIKey=NIHSNFSFDGHHRG-SDNWHVSQSA-N

InChI=1S/C22H26N4O/c1-26(2)16-6-15-23-22-19-7-4-5-8-20(19)24-21(25-22)14-11-17-9-12-18(27-3)13-10-17/h4-5,7-14H,6,15-16H2,1-3H3,(H,23,24,25)/b14-11+

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Condition	Potency
p53 signaling pathway 5 Target ID: map04115 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10617466\|https://www.ncbi.nlm.nih.gov/pubmed/14614447\|https://www.ncbi.nlm.nih.gov/pubmed/26693057\|https://www.ncbi.nlm.nih.gov/pubmed/26250460	Modulator 846
Transcriptional repressor protein YY1 1 Target ID: P25490 Gene ID: 7528.0 Gene Symbol: YY1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/30755813	Binding Agent 1076

PubMed

Title	Date	PubMed
Subchronic oral toxicity and metabolite profiling of the p53 stabilizing agent, CP-31398, in rats and dogs.	2011-11-18	21864638
p53-Reactivating small molecules induce apoptosis and enhance chemotherapeutic cytotoxicity in head and neck squamous cell carcinoma.	2011-01	21109480
Acridine derivatives activate p53 and induce tumor cell death through Bax.	2005-08	16177561
The Wilms tumor suppressor-1 target gene podocalyxin is transcriptionally repressed by p53.	2004-08-06	15155752

Substance Class	Chemical Created by `admin` on `Mon Mar 31 23:38:24 GMT 2025` Edited by `admin` on `Mon Mar 31 23:38:24 GMT 2025`
Record UNII	IN3WH41H3A
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

1,3-PROPANEDIAMINE, N3-(2-(2-(4-METHOXYPHENYL)ETHENYL)-4-QUINAZOLINYL)-N1,N1-DIMETHYL-

Preferred Name

English

CP-31398

Common Name

English

Code System Code Type Description

EPA CompTox

DTXSID101128317

Created by admin on Mon Mar 31 23:38:24 GMT 2025 , Edited by admin on Mon Mar 31 23:38:24 GMT 2025

PRIMARY

FDA UNII

IN3WH41H3A

Created by admin on Mon Mar 31 23:38:24 GMT 2025 , Edited by admin on Mon Mar 31 23:38:24 GMT 2025

PRIMARY

CAS

259199-65-0

Created by admin on Mon Mar 31 23:38:24 GMT 2025 , Edited by admin on Mon Mar 31 23:38:24 GMT 2025

PRIMARY

PUBCHEM

9950868

Created by admin on Mon Mar 31 23:38:24 GMT 2025 , Edited by admin on Mon Mar 31 23:38:24 GMT 2025

PRIMARY

Related Record Type Details


					IN3WH41H3A

CP-31398

ACTIVE MOIETY