Details
Stereochemistry | ACHIRAL |
Molecular Formula | CH3 |
Molecular Weight | 15.0345 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 1 |
SHOW SMILES / InChI
SMILES
[CH3+]
InChI
InChIKey=JUHDUIDUEUEQND-UHFFFAOYSA-N
InChI=1S/CH3/h1H3/q+1
Molecular Formula | CH4 |
Molecular Weight | 16.0425 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Biologically, methanogens in the colon can use carbon dioxide and hydrogen to produce methane as a by-product. It was previously considered that humans do not utilize methane. However, in a recent study on rodents, results demonstrated that methane could exert anti-inflammatory, anti-oxidant and anti-apoptotic effects. Furthermore, it has bee suggested, that methane-rich saline could be a promising therapeutic agent for clinical treatment of pancreatitis. Methane gas may also be a promising option for the clinical treatment of Acute Lung Injury and Spinal Cord Injury. The exact mechanism underlying the antioxidative, anti-inflammatory, and antiapoptotic activities of methane is not obvious. Different researchers have proposed different hypotheses. Some have hypothesized that methane might accumulate transiently at the interfaces of cell membranes, thereby changing the physicochemical properties or the in-situ functionality of proteins embedded within this environment. Other investigators have suggested that methane could exert effects on membrane channels affecting G-proteins, membrane or receptor-mediated signaling, or acetylcholine-activated ion channel kinetics. It is unknown if mammalian cells contain an oxygenase that is capable of using methane as a substrate, or if the biological effects of methane are caused by the formation of small amounts of the reactive alcohol, methanol, and/or changes in the redox milieu of the cell due to changes in NAD(P)+/NAD(P)H ratio, and whether or not there is a cellular “receptor” for methane. There are also questions remaining around the difference between intraperitoneal vs inhaled administration of methane.
Approval Year
PubMed
Title | Date | PubMed |
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Metabolism of n-propylamine, isopropylamine, and 1,3-propane diamine by Mycobacterium convolutum. | 1975 Oct |
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Interactions of short chain aliphatic hydrocarbons with human blood and haemoglobin A solutions. | 1976 Jul |
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[Electrophoretic study of aged butyrylcholinesterase after inhibition by soman]. | 1984 Mar |
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Characterization of the urinary metabolites of merbarone in cancer patients. | 1991 Jan-Feb |
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Crystal structure of a bacterial non-haem iron hydroxylase that catalyses the biological oxidation of methane. | 1993 Dec 9 |
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Automated detection of cytochalasin-B blocked binucleated lymphocytes for scoring micronuclei. | 1993 Jul |
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Inhibition of methanogenesis by human bile. | 1995 Sep |
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Ruminococcus hydrogenotrophicus sp. nov., a new H2/CO2-utilizing acetogenic bacterium isolated from human feces. | 1996 Sep |
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Effects of chair-restraint on gastrointestinal transit time and colonic fermentation in male rhesus monkey (Macaca mulatta). | 1997 Aug |
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Death due to a methane gas explosion in a tunnel on urban reclaimed land. | 1997 Jun |
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Crystal structure of methyl-coenzyme M reductase: the key enzyme of biological methane formation. | 1997 Nov 21 |
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Fructans of chicory: intestinal transport and fermentation of different chain lengths and relation to fructose and sorbitol malabsorption. | 1998 Aug |
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Decompression sickness risk in rats by microbial removal of dissolved gas. | 1998 Sep |
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Identification of an extracellular agent [correction of catalyst] of carbon tetrachloride dehalogenation from Pseudomonas stutzeri strain KC as pyridine-2, 6-bis(thiocarboxylate). | 1999 Aug 11 |
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HG/LT-GC/ICP-MS coupling for identification of metal(loid) species in human urine after fish consumption. | 2001 Nov |
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Nitric oxide inhibits DNA-adduct excision in nucleotide excision repair. | 2004 Apr 15 |
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Persistent organochlorine residues in human breast milk from Hanoi and Hochiminh City, Vietnam: contamination, accumulation kinetics and risk assessment for infants. | 2004 Jun |
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Infrared spectrum and structure of CH2=ThH2. | 2005 Aug 11 |
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Infrared spectra of CH3-CrH, CH3-WH, CH2=WH2, and CH[triple bond]WH3 formed by activation of CH4 with Cr and W atoms. | 2005 Oct 17 |
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Methane activation by laser-ablated V, Nb, and Ta atoms: Formation of CH3-MH, CH2=MH2, CHMH3-, and (CH3)2MH2. | 2006 Mar 23 |
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Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA. | 2006 May 17 |
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Infrared spectrum and bonding in uranium methylidene dihydride, CH2=UH2. | 2007 Jun 11 |
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Autoxidation of platinum(IV) hydrocarbyl hydride complexes to form platinum(IV) hydrocarbyl hydroperoxide complexes. | 2009 Feb 16 |
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Diesel and biodiesels induce hepatic palmitoyl-CoA oxidase enzymatic activity through different molecular mechanisms in rats. | 2012 Jun |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/28740568
in rats: methane-rich saline (MS) was injected intraperitoneally in rats after spinal cord injury (SCI). Hematoxylin-eosin (HE) staining, oxidative stress, inflammatory parameters, and cell apoptosis were detected 72 h after SCI to determine the optimal dose. According to calculation, the concentration of MS was 0.99 mmol/l.
Route of Administration:
Intraperitoneal
Substance Class |
Chemical
Created
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Edited
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Record UNII |
IM9JMM7N0Y
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Record Status |
Validated (UNII)
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Record Version |
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29437
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644094
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IM9JMM7N0Y
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Methenium
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IONIC MOIETY |