ACTISOMIDE

Possibly Marketed Outside US

Details

Stereochemistry	RACEMIC
Molecular Formula	C23H35N3O
Molecular Weight	369.5435
Optical Activity	( + / - )
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@]12CCCCN1C(C)=NC(=O)[C@]2(CCN(C(C)C)C(C)C)C3=CC=CC=C3

InChI

InChIKey=QAHRRCMLXFLZTF-FYYLOGMGSA-N

InChI=1S/C23H35N3O/c1-17(2)25(18(3)4)16-14-23(20-11-7-6-8-12-20)21-13-9-10-15-26(21)19(5)24-22(23)27/h6-8,11-12,17-18,21H,9-10,13-16H2,1-5H3/t21-,23-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C23H35N3O
Molecular Weight	369.5435
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2457760 | https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1527-3466.1989.tb00388.x

ACTISOMIDE is a class 1A/1B antiarrhythmic agent. It blocks sodium channels in a manner similar to lidocaine and mexiletine. It is a well-tolerated, effective agent against both atrial and ventricular arrhythmias.

Approval Year

PubMed

Title	Date	PubMed
SC-36602, a new antiarrhythmic agent: comparison of its cardiovascular profile with that of other antiarrhythmic drugs.	1988 Jun	2457760
Metabolism of actisomide in the dog, monkey and man: a novel rearrangement of N-dealkylated metabolites.	1992 Apr-Jun	1425813
Pharmacokinetics of a novel antiarrhythmic drug, actisomide.	1993 Mar	8464818

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:10:03 GMT 2023` Edited by `admin` on `Fri Dec 15 15:10:03 GMT 2023`
Record UNII	IJQ29N87NR
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ACTISOMIDE

Official Name

English

SC 36602

Code

English

3H-PYRIDO(1,2-C)PYRIMIDIN-3-ONE, 4-(2-(BIS(1-METHYLETHYL)AMINO)ETHYL)-4,4A,5,6,7,8-HEXAHYDRO-1-METHYL-4-PHENYL-, CIS-(±)-

Common Name

English

(±)-CIS-4-(2-(DIISOPROPYLAMINO)ETHYL)-4,4A,5,6,7,8-HEXAHYDRO-1-METHYL-4-PHENYL-3H-PYRIDO(1,2-C)PYRIMIDIN-3-ONE

Common Name

English

actisomide [INN]

Common Name

English

ACTISOMIDE [USAN]

Common Name

English

SC-36602

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C47793