PHANQUONE

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H6N2O2
Molecular Weight	210.1882
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of PHANQUONE

Structure Search

SMILES

O=C1C(=O)C2=C(C=CC=N2)C3=C1N=CC=C3

InChI

InChIKey=VLPADTBFADIFKG-UHFFFAOYSA-N

InChI=1S/C12H6N2O2/c15-11-9-7(3-1-5-13-9)8-4-2-6-14-10(8)12(11)16/h1-6H

HIDE SMILES / InChI

Molecular Formula	C12H6N2O2
Molecular Weight	210.1882
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:59141 | https://www.ncbi.nlm.nih.gov/pubmed/7022141 | https://www.ncbi.nlm.nih.gov/pubmed/13919297 | https://www.ncbi.nlm.nih.gov/pubmed/7029215 | https://www.ncbi.nlm.nih.gov/pubmed/13898236 | https://patents.google.com/patent/US4183941

Phanquone is an orthoquinone that is the 5,6-diketo derivative of 4,7-phenanthroline. It derives from a hydride of a 4,7-phenanthroline. Phanquone (Entobex) is an anti-mycotic drug with anti-protozoal activity. Phanquone is active against a wide range of Gram-positive and Gram-negative organisms. Phanquone partically inhibited oxygen consumption by Escherichia coli and Staphylococcus aureus. It was also tried on cases of rheumatoid diseases.

Originator

Approval Year

PubMed

PubMed

Title	Date	PubMed

Patents

Patents

Sample Use Guides

In Vivo Use Guide

Phanquone (entobex) was given in doses of 100 mg. twice daily by mouth for seven days, repeated at intervals of a week

Route of Administration: Oral

In Vitro Use Guide

Phanquone inhibited E.coli 205 growth with MIC =1 ug/ml

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:05:53 GMT 2023` Edited by `admin` on `Fri Dec 15 15:05:53 GMT 2023`
Record UNII	ID94IS6N8J
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

PHANQUONE

Common Name

English

C-11925

Code

English

phanquinone [INN]

Common Name

English

Phanquinone [WHO-DD]

Common Name

English

GNF-PF-1759

Code

English

PHANQUINONE [MI]

Common Name

English

4,7-PHENANTHROLINE-5,6-QUINONE

Systematic Name

English

PHANQUINONE

Official Name

English

Classification Tree Code System Code

NCI_THESAURUS

C277

Created by admin on Fri Dec 15 15:05:53 GMT 2023 , Edited by admin on Fri Dec 15 15:05:53 GMT 2023

WHO-VATC

QP51AX03

Created by admin on Fri Dec 15 15:05:53 GMT 2023 , Edited by admin on Fri Dec 15 15:05:53 GMT 2023

NCI_THESAURUS

C28394

Created by admin on Fri Dec 15 15:05:53 GMT 2023 , Edited by admin on Fri Dec 15 15:05:53 GMT 2023

WHO-ATC

P01AX04

Created by admin on Fri Dec 15 15:05:53 GMT 2023 , Edited by admin on Fri Dec 15 15:05:53 GMT 2023

Code System Code Type Description

DRUG CENTRAL

3433

Created by admin on Fri Dec 15 15:05:53 GMT 2023 , Edited by admin on Fri Dec 15 15:05:53 GMT 2023

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SMS_ID

100000082225

Created by admin on Fri Dec 15 15:05:53 GMT 2023 , Edited by admin on Fri Dec 15 15:05:53 GMT 2023

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WIKIPEDIA

PHANQUINONE

Created by admin on Fri Dec 15 15:05:53 GMT 2023 , Edited by admin on Fri Dec 15 15:05:53 GMT 2023

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MERCK INDEX

m8582

Created by admin on Fri Dec 15 15:05:53 GMT 2023 , Edited by admin on Fri Dec 15 15:05:53 GMT 2023

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Merck Index

EPA CompTox

DTXSID3046112

Created by admin on Fri Dec 15 15:05:53 GMT 2023 , Edited by admin on Fri Dec 15 15:05:53 GMT 2023

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NCI_THESAURUS

C90620

Created by admin on Fri Dec 15 15:05:53 GMT 2023 , Edited by admin on Fri Dec 15 15:05:53 GMT 2023

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INN

924

Created by admin on Fri Dec 15 15:05:53 GMT 2023 , Edited by admin on Fri Dec 15 15:05:53 GMT 2023

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FDA UNII

ID94IS6N8J

Created by admin on Fri Dec 15 15:05:53 GMT 2023 , Edited by admin on Fri Dec 15 15:05:53 GMT 2023

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MESH

C004902

Created by admin on Fri Dec 15 15:05:53 GMT 2023 , Edited by admin on Fri Dec 15 15:05:53 GMT 2023

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EVMPD

SUB09742MIG

Created by admin on Fri Dec 15 15:05:53 GMT 2023 , Edited by admin on Fri Dec 15 15:05:53 GMT 2023

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CAS

84-12-8

Created by admin on Fri Dec 15 15:05:53 GMT 2023 , Edited by admin on Fri Dec 15 15:05:53 GMT 2023

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ECHA (EC/EINECS)

201-516-0

Created by admin on Fri Dec 15 15:05:53 GMT 2023 , Edited by admin on Fri Dec 15 15:05:53 GMT 2023

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PUBCHEM

6764

Created by admin on Fri Dec 15 15:05:53 GMT 2023 , Edited by admin on Fri Dec 15 15:05:53 GMT 2023

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DRUG BANK

DB13469

Created by admin on Fri Dec 15 15:05:53 GMT 2023 , Edited by admin on Fri Dec 15 15:05:53 GMT 2023

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CHEBI

59141

Created by admin on Fri Dec 15 15:05:53 GMT 2023 , Edited by admin on Fri Dec 15 15:05:53 GMT 2023

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ChEMBL

CHEMBL531048

Created by admin on Fri Dec 15 15:05:53 GMT 2023 , Edited by admin on Fri Dec 15 15:05:53 GMT 2023

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Related Record Type Details


					ID94IS6N8J

PHANQUONE

ACTIVE MOIETY