FLUZINAMIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H13F3N2O2
Molecular Weight	274.239
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CNC(=O)N1CC(C1)OC2=CC=CC(=C2)C(F)(F)F

InChI

InChIKey=YULWJRNIKFFGNU-UHFFFAOYSA-N

InChI=1S/C12H13F3N2O2/c1-16-11(18)17-6-10(7-17)19-9-4-2-3-8(5-9)12(13,14)15/h2-5,10H,6-7H2,1H3,(H,16,18)

HIDE SMILES / InChI

Molecular Formula	C12H13F3N2O2
Molecular Weight	274.239
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4022365 |

Fluzinamide (AHR-8559), an anticonvulsant agent that was studied in patients with refractory partial seizures. However, information about the further development of this drug is not available.

Approval Year

PubMed

Title	Date	PubMed
Anticonvulsant action of fluzinamide (AHR-8559) on kindled amygdaloid seizures.	1984 Aug	6745221
Simultaneous determination of fluzinamide and three of its active metabolites in plasma by high-performance liquid chromatography.	1984 Dec 12	6530465
Pilot study of fluzinamide (N-methyl-3-[3-(trifluoromethyl)phenoxy]-1-azetidinecarboxamide) in refractory partial seizures.	1985 Aug	4022365
Pharmacokinetic and dose tolerability study of ADD 94057 in comedicated patients with partial seizures.	1992 Jan-Feb	1733743

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:25:12 UTC 2023` Edited by `admin` on `Fri Dec 15 17:25:12 UTC 2023`
Record UNII	IAF7F741SX
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FLUZINAMIDE

Official Name

English

fluzinamide [INN]

Common Name

English

1-AZETIDINECARBOXAMIDE, N-METHYL-3-(3-(TRIFLUOROMETHYL)PHENOXY)-

Systematic Name

English

AHR-8559

Code

English

FLUZINAMIDE [USAN]

Common Name

English

N-METHYL-3-((.ALPHA.,.ALPHA.,.ALPHA.-TRIFLUORO-M-TOLYL)OXY)-1-AZETIDINECARBOXAMIDE

Systematic Name

English

Code System Code Type Description

FDA UNII

IAF7F741SX