METICRANE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H13NO4S2
Molecular Weight	275.345
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=C(C=C2C(CCCS2(=O)=O)=C1)S(N)(=O)=O

InChI

InChIKey=FNQQBFNIYODEMB-UHFFFAOYSA-N

InChI=1S/C10H13NO4S2/c1-7-5-8-3-2-4-16(12,13)10(8)6-9(7)17(11,14)15/h5-6H,2-4H2,1H3,(H2,11,14,15)

HIDE SMILES / InChI

Molecular Formula	C10H13NO4S2
Molecular Weight	275.345
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.jstage.jst.go.jp/article/analscix/23/0/23_0_x119/_pdf
Curator's Comment: Description was created based on several sources, including https://www.drugs.com/international/meticrane.html and http://www.genome.jp/dbget-bin/www_bget?D01605

Meticrane is a diuretic. Meticrane is used to treat essential hypertension.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Translocator protein 13 Target ID: CHEMBL5742 Sources: https://www.medchemexpress.com/Meticrane.html	Inhibitor 8297		1.0 µM [IC50]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Hypertension 567 Sources: https://www.ncbi.nlm.nih.gov/pubmed/5745602	Primary		Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
[Clinical trial of a new diuretic: meticrane].	1968 Jan	5745602
[Resorption, distribution, excretion and metabolism in rat of a new diuretic: meticrane].	1970 Jul-Aug	5485056

Patents

Sample Use Guides

In Vivo Use Guide

Tab. 150mg

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:43:53 GMT 2023` Edited by `admin` on `Fri Dec 15 15:43:53 GMT 2023`
Record UNII	I7EKN1924Q
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

METICRANE

Official Name

English

METICRANE [MI]

Common Name

English

SD-17102

Code

English

Meticrane [WHO-DD]

Common Name

English

NSC-759309

Code

English

SD 17102

Code

English

METICRANE [MART.]

Common Name

English

meticrane [INN]

Common Name

English

METICRANE [JAN]

Common Name

English

ARRESTEN

Brand Name

English

6-METHYLTHIOCHROMAN-7-SULFONAMIDE 1,1-DIOXIDE

Systematic Name

English

Classification Tree Code System Code

WHO-VATC

QC03BA09