CHLORPHENESIN

Details

Stereochemistry	RACEMIC
Molecular Formula	C9H11ClO3
Molecular Weight	202.635
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

OCC(O)COC1=CC=C(Cl)C=C1

InChI

InChIKey=MXOAEAUPQDYUQM-UHFFFAOYSA-N

InChI=1S/C9H11ClO3/c10-7-1-3-9(4-2-7)13-6-8(12)5-11/h1-4,8,11-12H,5-6H2

HIDE SMILES / InChI

Molecular Formula	C9H11ClO3
Molecular Weight	202.635
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description

Chlorphenesin is a preservative and cosmetic biocide that helps prevent the growth of microorganisms. In cosmetics and personal care products, Chlorphenesin is used in the formulation of aftershave lotions, bath products, cleansing products, deodorants, hair conditioners, makeup, skin care products, personal cleanliness products, and shampoos. Chlorphenesin has been reported to cause irritation and contact dermatitis in some people, particularly those with sensitive and dry skin. The Cosmetic Ingredient Review (CIR) expert panel released a safety assessment in October 2012, however, that stated chlorphenesin at 0.3 percent (as it exists in personal care products) was classified as having “negligible dermal irritation potential.”

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
histamine secretion 4	Inhibitor 8,297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Sunburns 22	Inactive ingredient		Approved 8,429	Volu-Firm

PubMed

Show entries

Title	Date	PubMed
Inhibition of histamine and SRS-A from monkey lung tissue by chlorophenesin.	1971 Aug	4105542
Effect of a muscle relaxant, chlorphenesin carbamate, on the spinal neurons of rats.	1984 Sep	6503049

Showing 1 to 2 of 2 entries

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Patents

Sample Use Guides

In Vivo Use Guide

The ingredient is allowed at up to 0.3 percent in cosmetic products in the U.S. and Europe.

Route of Administration: Topical

In Vitro Use Guide

The action of chlorphenesin on histamine release was investigated with isolated human leukocytes. Cells from ragweed or grass pollen sensitive donors were added to tubes containing a variable concentration of the chlorphenesin (2*10^-4-1*10^-3 M) and a constant concentration of ragweed antigen E or rye grass Group I antigen which was sufficient for 60% to 80% histamine release. A chlorphenesin concentration of between 0.3 and 0.6 mM causes 50 % inhibition.