CHLORPHENESIN

Details

Stereochemistry	RACEMIC
Molecular Formula	C9H11ClO3
Molecular Weight	202.635
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OCC(O)COC1=CC=C(Cl)C=C1

InChI

InChIKey=MXOAEAUPQDYUQM-UHFFFAOYSA-N

InChI=1S/C9H11ClO3/c10-7-1-3-9(4-2-7)13-6-8(12)5-11/h1-4,8,11-12H,5-6H2

HIDE SMILES / InChI

Molecular Formula	C9H11ClO3
Molecular Weight	202.635
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: http://www.cir-safety.org/sites/default/files/Chlorp092012rep.pdf
Curator's Comment: The description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/1271399 | https://www.ncbi.nlm.nih.gov/pubmed/24628968 | https://www.ncbi.nlm.nih.gov/pubmed/2941223 |

Chlorphenesin is a preservative and cosmetic biocide that helps prevent the growth of microorganisms. In cosmetics and personal care products, Chlorphenesin is used in the formulation of aftershave lotions, bath products, cleansing products, deodorants, hair conditioners, makeup, skin care products, personal cleanliness products, and shampoos. Chlorphenesin has been reported to cause irritation and contact dermatitis in some people, particularly those with sensitive and dry skin. The Cosmetic Ingredient Review (CIR) expert panel released a safety assessment in October 2012, however, that stated chlorphenesin at 0.3 percent (as it exists in personal care products) was classified as having “negligible dermal irritation potential.”

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
histamine secretion 4 Target ID: GO:0001821 Sources: https://www.ncbi.nlm.nih.gov/pubmed/4186918	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Sunburns 22 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a8276be2-93f1-4782-b206-93ea31036216	Inactive ingredient		Approved 8429	Volu-Firm Approved Use Unknown

PubMed

Title	Date	PubMed
Inhibition of histamine and SRS-A from monkey lung tissue by chlorophenesin.	1971 Aug	4105542
Effect of a muscle relaxant, chlorphenesin carbamate, on the spinal neurons of rats.	1984 Sep	6503049
Medical treatment of the major neuralgias.	1988 Dec	3074423

Patents

Sample Use Guides

In Vivo Use Guide

The ingredient is allowed at up to 0.3 percent in cosmetic products in the U.S. and Europe.

Route of Administration: Topical

In Vitro Use Guide

The action of chlorphenesin on histamine release was investigated with isolated human leukocytes. Cells from ragweed or grass pollen sensitive donors were added to tubes containing a variable concentration of the chlorphenesin (2*10^-4-1*10^-3 M) and a constant concentration of ragweed antigen E or rye grass Group I antigen which was sufficient for 60% to 80% histamine release. A chlorphenesin concentration of between 0.3 and 0.6 mM causes 50 % inhibition.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:33:29 UTC 2023` Edited by `admin` on `Fri Dec 15 16:33:29 UTC 2023`
Record UNII	I670DAL4SZ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CHLORPHENESIN

Official Name

English

CHLORPHENESIN [MART.]

Common Name

English

CHLORPHENESIN [MI]

Common Name

English

Chlorphenesin [WHO-DD]

Common Name

English

chlorphenesin [INN]

Common Name

English

CHLORPHENESIN [VANDF]

Common Name

English

NSC-6401

Code

English

CHLORPHENESIN [INCI]

Common Name

English

Classification Tree Code System Code

WHO-ATC

D01AE07