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Details

Stereochemistry ABSOLUTE
Molecular Formula C19H26O2
Molecular Weight 286.4093
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CANNABIDIVARIN

SMILES

CCCc1cc(c([C@]2([H])C=C(C)CC[C@@]2([H])C(=C)C)c(c1)O)O

InChI

InChIKey=REOZWEGFPHTFEI-JKSUJKDBSA-N
InChI=1S/C19H26O2/c1-5-6-14-10-17(20)19(18(21)11-14)16-9-13(4)7-8-15(16)12(2)3/h9-11,15-16,20-21H,2,5-8H2,1,3-4H3/t15-,16+/m0/s1

HIDE SMILES / InChI

Molecular Formula C19H26O2
Molecular Weight 286.4093
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Cannabidivarin is a homolog of cannabidiol, with a well-established antiepileptiform profile in preclinical studies, both in vitro and in vivo animal models of epilepsy. The oral bioavailability of cannabidivarin is very low (about 6%) due to erratic absorption and first pass metabolism. After oral administration, the maximum plasma concentration of Cannabidivarin is rising in about three hours and the drug has a large volume of distribution, because of his link to protein plasma, being highly liposoluble, so CBDV can penetrate well to the brain. Cannabidivarin is also metabolized in the liver to 7-COOH and 6-OH metabolites, but the mechanism is also unknown. There is an ongoing phase II double-blind, placebo-controlled trial that is assessing the efficacy and safety of cannabidivarin in Children With Autism Spectrum Disorder (ASD).

Originator

Sources: Tetrahedron Letters (1969), (3), 145-7.

Approval Year

PubMed

PubMed

TitleDatePubMed
Preclinical safety and efficacy of cannabidivarin for early life seizures.
2019 Apr
Patents

Sample Use Guides

10 mg/kg/day for 12 weeks
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Sat Jun 26 04:18:44 UTC 2021
Edited
by admin
on Sat Jun 26 04:18:44 UTC 2021
Record UNII
I198VBV98I
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CANNABIDIVARIN
Common Name English
CANNABIDIVAROL
Common Name English
1,3-BENZENEDIOL, 2-((1R,6R)-3-METHYL-6-(1-METHYLETHENYL)-2-CYCLOHEXEN-1-YL)-5-PROPYL-
Systematic Name English
2-((1R,6R)-3-METHYL-6-(PROP-1-EN-2-YL)CYCLOHEX-2-EN-1-YL)-5-PROPYLBENZENE-1,3-DIOL
Systematic Name English
RESORCINOL, 2-P-MENTHA-1,8-DIEN-3-YL-5-PROPYL-
Common Name English
GWP-42006
Common Name English
CBDV
Code English
CBD-V
Code English
CANNABIDIVARIN [NFLIS-DRUG]
Common Name English
GWP42006
Code English
Classification Tree Code System Code
FDA ORPHAN DRUG 549216
Created by admin on Sat Jun 26 04:18:44 UTC 2021 , Edited by admin on Sat Jun 26 04:18:44 UTC 2021
EU-Orphan Drug EU/3/18/1977
Created by admin on Sat Jun 26 04:18:44 UTC 2021 , Edited by admin on Sat Jun 26 04:18:44 UTC 2021
FDA ORPHAN DRUG 572416
Created by admin on Sat Jun 26 04:18:44 UTC 2021 , Edited by admin on Sat Jun 26 04:18:44 UTC 2021
Code System Code Type Description
WIKIPEDIA
CANNABIDIVARIN
Created by admin on Sat Jun 26 04:18:44 UTC 2021 , Edited by admin on Sat Jun 26 04:18:44 UTC 2021
PRIMARY
CAS
24274-48-4
Created by admin on Sat Jun 26 04:18:44 UTC 2021 , Edited by admin on Sat Jun 26 04:18:44 UTC 2021
PRIMARY
EVMPD
SUB184452
Created by admin on Sat Jun 26 04:18:44 UTC 2021 , Edited by admin on Sat Jun 26 04:18:44 UTC 2021
PRIMARY
FDA UNII
I198VBV98I
Created by admin on Sat Jun 26 04:18:44 UTC 2021 , Edited by admin on Sat Jun 26 04:18:44 UTC 2021
PRIMARY
PUBCHEM
11601669
Created by admin on Sat Jun 26 04:18:44 UTC 2021 , Edited by admin on Sat Jun 26 04:18:44 UTC 2021
PRIMARY
Related Record Type Details
PARENT -> CONSTITUENT ALWAYS PRESENT
Cannabidiol Class
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ACTIVE MOIETY