PHENCARBAMIDE NAPADISILATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H24N2OS.C10H8O6S2
Molecular Weight	616.769
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OS(=O)(=O)C1=CC=CC2=C(C=CC=C12)S(O)(=O)=O.CCN(CC)CCSC(=O)N(C3=CC=CC=C3)C4=CC=CC=C4

InChI

InChIKey=ZZNARJBYZHRHKJ-UHFFFAOYSA-N

InChI=1S/C19H24N2OS.C10H8O6S2/c1-3-20(4-2)15-16-23-19(22)21(17-11-7-5-8-12-17)18-13-9-6-10-14-18;11-17(12,13)9-5-1-3-7-8(9)4-2-6-10(7)18(14,15)16/h5-14H,3-4,15-16H2,1-2H3;1-6H,(H,11,12,13)(H,14,15,16)

HIDE SMILES / InChI

Molecular Formula	C10H8O6S2
Molecular Weight	288.297
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C19H24N2OS
Molecular Weight	328.472
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 958, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ | Vasudeva Rau. U. (1968) The Antiseptic: A Monthly Journal of Medicine and Surgery, retrieved from: https://books.google.ru/books?id=ZrE6AQAAIAAJ | Milne, G.W.A. (2018) Drugs: Synonyms and Properties, retrieved from: https://books.google.ru/books?id=xUlaDwAAQBAJ

Phencarbamide is an anti-spasmodic and anticholinergic drug used during parturition. It has a specific antispasmodic action on the smooth muscle, both directly like papaverine and through the autonomic nervous system (atropine effect). It has also an analgesic effect of its own. Side-effects generally associated with the atropine group of drugs.

Approval Year

PubMed

Title	Date	PubMed
Propranolol-bunolol and phencarbamide in chloroform-induced ventricular fibrillation in mice.	1973-06	4582610
[Colorimetric determination of phencarbamide and its hydrochloride and naphthalene disulfonate salts].	1971-11	5138619
Anticonvulsant effect of phencarbamide and its modification by reserpine and tranylcypromine.	1971-03	4994549
A study of the antiarrhythmic and local anaesthetic actions of phencarbamide.	1970-05	5470024
[Spasmolytic effect of phencarbamide on the uterine cervix during early puerperium].	1966-08-26	5995198
[PRACTICAL EXPERIENCES WITH THE SPASMOLYTIC AGENT ESCORPAL IN OBSTETRICS].	1965-01-30	14271426
[SPASMOLYSIS IN OBSTETRICS: CLINICAL EXPERIENCE WITH PHENCARBAMIDE].	1964-09-26	14303609
[EXPERIENCES WITH A NEW SPASMOLYTIC AGENT (ESCORPAL) IN OBSTETRICS].	1964-06-20	14248671
[PHENCARBAMIDE, A NEW SPASMOLYTIC COMBINED WITH DOLVIRAN].	1964-06	14243633
[On the pharmacology of the uterine action of phencarbamide].	1963	14001293
[On the clinical experiences with the spasmolytic Bayer 1355 (phencarbamide) in obstetrics].	1963	13966124

Substance Class	Chemical Created by `admin` on `Tue Apr 01 16:24:12 GMT 2025` Edited by `admin` on `Tue Apr 01 16:24:12 GMT 2025`
Record UNII	HXQ3ENP4FG
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PHENCARBAMIDE NAPADISILATE

Common Name

English

FENCARBAMIDE NAPADISILATE

Preferred Name

English

GELOSEDINE

Brand Name

English

PHENCARBAMIDE 1,5-NAPHTHALENEDISULFONATE [MI]

Common Name

English

FENCARBAMIDE 1,5-NAPHTHALENEDISULFONATE

Common Name

English

FENCARBAMIDE NAPHTHALENE DISULFONATE

Common Name

English

1,5-NAPHTHALENEDISULFONIC ACID, COMPD. WITH S-(2-(DIETHYLAMINO)ETHYL) DIPHENYLCARBAMOTHIOATE

Common Name

English

Fencarbamide napadisilate [WHO-DD]

Common Name

English

PHENCARBAMIDE 1,5-NAPHTHALENEDISULFONATE

Common Name

English

PHENCARBAMIDE NAPHTHALENEDISULFONATE

Common Name

English

CARBAMOTHIOIC ACID, DIPHENYL-, S-(2-(DIETHYLAMINO)ETHYL) ESTER, 1,5-NAPHTHALENEDISULFONATE

Systematic Name

English

1,5-NAPHTHALENEDISULFONIC ACID, COMPD. WITH 2-(DIETHYLAMINO)ETHYL N,N-DIPHENYLCARBAMOTHIOATE (1:1)

Systematic Name

English

CARBAMOTHIOIC ACID, DIPHENYL-, S-(2-(DIETHYLAMINO)ETHYL) ESTER, 1,5-NAPHTHALENEDISULFONATE (1:1)

Systematic Name

English

Code System Code Type Description

CAS

72017-58-4