Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C20H32NO.I |
| Molecular Weight | 429.3787 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[I-].C[N+]3(CCC(O)(C1CCCCC1)C2=CC=CC=C2)CCCC3
InChI
InChIKey=KKNHYFDAGNWDPZ-UHFFFAOYSA-M
InChI=1S/C20H32NO.HI/c1-21(15-8-9-16-21)17-14-20(22,18-10-4-2-5-11-18)19-12-6-3-7-13-19;/h2,4-5,10-11,19,22H,3,6-9,12-17H2,1H3;1H/q+1;/p-1
| Molecular Formula | C20H31NO |
| Molecular Weight | 301.4662 |
| Charge | 0 |
| Count |
|
| Stereochemistry | MIXED |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
| Molecular Formula | HI |
| Molecular Weight | 127.9124 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Tricyclamol is a quaternary ammonium compound, which is a crystalline odorless substance, readily soluble in water. It may be given by mouth or by subcutaneous injection. Tricyclamol was used for its spasmolytic action on smooth muscle. In animals it inhibits the spasmogenic effects of acetylcholine (ACh), carbachol, pilocarpine and barium chloride. In relaxing ACh-induced spasm of isolated rabbit ileum the activities of the dextro and laevo isomers of tricyclamol were approximately 0.006 and 2 times that of atropine sulphate respectively. Further, in inhibiting the stretch reflex of isolated guinea-pig ileum the laevo isomer was much more active than the dextro and about twice as potent as the racemate. Tricyclamol blocks the superior cervical ganglion. Tricyclamol chloride has a marked effect in reducing the motility of the stomach and duodenum, and to a far greater extent than the results produced by hyoscyamine. This action may be of value in controlling the pain of peptic ulceration, since it is likely that the pain, at least in part, is due to spasm.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Death attributed to ventricular arrhythmia induced by thioridazine in combination with a single Contac C capsule. | 1978 Oct 7 |
|
| Effects of mianserin in neuroleptic-induced parkinsonism. | 1986 |
|
| Rapid cycling following antidepressant in an adolescent. | 1990 May 15 |
|
| Neuroleptics and family history of Parkinson diseases: case report. | 2001 May |
|
| Simultaneous determination of enantiomers of structurally related anticholinergic analogs in human serum by liquid chromatography-electrospray ionization mass spectrometry with on-line sample cleanup. | 2001 Oct 25 |
|
| A possible association between high normal and high dose olanzapine and prolongation of the PR interval. | 2002 Jun |
|
| NMDA receptors might be involved in the impairing effects of procyclidine on cognition. | 2003 Dec |
|
| Anti-parkinsonian agents procyclidine and ethopropazine alleviate thermal hyperalgesia in neuropathic rats. | 2003 May |
|
| Protection by sustained release of physostigmine and procyclidine of soman poisoning in rats. | 2004 Nov 28 |
|
| Soman-induced convulsions in rats terminated with pharmacological agents after 45 min: neuropathology and cognitive performance. | 2005 Jan |
|
| The combination of donepezil and procyclidine protects against soman-induced seizures in rats. | 2007 Apr 15 |
|
| Clozapine and co-prescribed psychotropics: a short report. | 2008 Apr 25 |
|
| Antiparkinson drugs used as prophylactics for nerve agents: studies of cognitive side effects in rats. | 2008 Jun |
|
| Mechanisms of action of antipsychotic drugs of different classes, refractoriness to therapeutic effects of classical neuroleptics, and individual variation in sensitivity to their actions: Part II. | 2009 Dec |
|
| Selective T-type calcium channel blockade alleviates hyperalgesia in ob/ob mice. | 2009 Nov |
|
| Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method. | 2010 Dec |
|
| Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. | 2011 Jul 14 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 05:09:23 GMT 2023
by
admin
on
Sat Dec 16 05:09:23 GMT 2023
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| Record UNII |
HSX230668V
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| Record Status |
Validated (UNII)
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| Record Version |
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6856-40-2
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201805
Created by
admin on Sat Dec 16 05:09:24 GMT 2023 , Edited by admin on Sat Dec 16 05:09:24 GMT 2023
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HSX230668V
Created by
admin on Sat Dec 16 05:09:24 GMT 2023 , Edited by admin on Sat Dec 16 05:09:24 GMT 2023
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