Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C20H32NO |
| Molecular Weight | 302.4742 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 1 |
SHOW SMILES / InChI
SMILES
C[N+]3(CCC(O)(C1CCCCC1)C2=CC=CC=C2)CCCC3
InChI
InChIKey=FRBBPWXCRBHYJQ-UHFFFAOYSA-N
InChI=1S/C20H32NO/c1-21(15-8-9-16-21)17-14-20(22,18-10-4-2-5-11-18)19-12-6-3-7-13-19/h2,4-5,10-11,19,22H,3,6-9,12-17H2,1H3/q+1
| Molecular Formula | C20H31NO |
| Molecular Weight | 301.4662 |
| Charge | 0 |
| Count |
|
| Stereochemistry | MIXED |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
Tricyclamol is a quaternary ammonium compound, which is a crystalline odorless substance, readily soluble in water. It may be given by mouth or by subcutaneous injection. Tricyclamol was used for its spasmolytic action on smooth muscle. In animals it inhibits the spasmogenic effects of acetylcholine (ACh), carbachol, pilocarpine and barium chloride. In relaxing ACh-induced spasm of isolated rabbit ileum the activities of the dextro and laevo isomers of tricyclamol were approximately 0.006 and 2 times that of atropine sulphate respectively. Further, in inhibiting the stretch reflex of isolated guinea-pig ileum the laevo isomer was much more active than the dextro and about twice as potent as the racemate. Tricyclamol blocks the superior cervical ganglion. Tricyclamol chloride has a marked effect in reducing the motility of the stomach and duodenum, and to a far greater extent than the results produced by hyoscyamine. This action may be of value in controlling the pain of peptic ulceration, since it is likely that the pain, at least in part, is due to spasm.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| A controlled trial of anti-Parkinson drugs in drug-induced Parkinsonism. | 1966 Jun |
|
| Drug-induced extrapyramidal symptoms: their incidence and treatment. | 1967 Jan |
|
| Double-blind comparison of levodopa and procyclidine in parkinsonism, with illustrations of levodopa-induced movement disorders. | 1970 Dec |
|
| Double-blind comparison of levodopa and procyclidine in parkinsonism, with illustrations of levodopa-induced movement disorders. | 1970 Dec |
|
| Central role of solar information flow in pregenetic evolution. | 1971 Jun |
|
| Parenteral long-acting phenothiazines. | 1972 Mar 25 |
|
| Letter: Delayed drug-induced dystonias. | 1973 Oct 20 |
|
| Death attributed to ventricular arrhythmia induced by thioridazine in combination with a single Contac C capsule. | 1978 Oct 7 |
|
| Sleep disturbance associated with fluphenazine HCl: a case report. | 1979 Jul |
|
| Fluphenazine enanthate and fluphenazine decanoate in the treatment of schizophrenic outpatients: extrapyramidal symptoms and therapeutic effect. | 1982 Mar |
|
| Toxic neurological reaction to lithium/thioridazine. | 1983 Apr 2 |
|
| Neuroleptic malignant syndrome. | 1983 Jun 18 |
|
| Rapid cycling following antidepressant in an adolescent. | 1990 May 15 |
|
| Acute dystonia due to amitriptyline. | 1992 May |
|
| Antipsychotic drug-induced dysphoria. | 1996 Oct |
|
| Bilateral ulnar nerve paralysis: an unreported complication of drug-induced extrapyramidal rigidity. | 1997 Jun |
|
| Anti-nicotinic properties of anticholinergic antiparkinson drugs. | 1998 Nov |
|
| An extrapyramidal reaction to ondansetron. | 1998 Oct |
|
| Effects of combinational prophylactics composed of physostigmine and procyclidine on soman-induced lethality, seizures and brain injuries. | 2002 Jan |
|
| Self-reported parkinsonian symptoms in the EPIC-Norfolk cohort. | 2005 Aug 24 |
|
| Lack of association between prepulse inhibition and antisaccadic deficits in chronic schizophrenia: implications for identification of schizophrenia endophenotypes. | 2005 May |
|
| Primary care use of antipsychotic drugs: an audit and intervention study. | 2005 Nov 29 |
|
| Efficacy of immediate and subsequent therapies against soman-induced seizures and lethality in rats. | 2006 Feb |
|
| Abdominal pain with rigidity secondary to the anti-emetic drug metoclopramide. | 2006 May |
|
| Pharmacological therapies against soman-induced seizures in rats 30 min following onset and anticonvulsant impact. | 2006 Oct 24 |
|
| An overview of the clinical use of ondansetron in preschool age children. | 2007 Jun |
|
| Simultaneous prescribing of atypical antipsychotics, conventional antipsychotics and anticholinergics-a European study. | 2007 Jun |
|
| Clozapine and co-prescribed psychotropics: a short report. | 2008 Apr 25 |
|
| Stuttering priapism--a review of the therapeutic options. | 2008 Aug |
|
| Anticonvulsant efficacy of drugs with cholinergic and/or glutamatergic antagonism microinfused into area tempestas of rats exposed to soman. | 2008 Feb |
|
| The present approaches to the development of prophylactic and therapeutic antidotes against nerve agents. | 2008 Jun |
|
| Amisulpride plus valproate vs haloperidol plus valproate in the treatment of acute mania of bipolar I patients: a multicenter, open-label, randomized, comparative trial. | 2008 Jun |
|
| Antiparkinson drugs used as prophylactics for nerve agents: studies of cognitive side effects in rats. | 2008 Jun |
|
| Enhanced cholinergic-mediated increase in the pro-inflammatory cytokine IL-6 in irritable bowel syndrome: role of muscarinic receptors. | 2008 Oct |
|
| Role of the central cholinergic system in the therapeutics of schizophrenia. | 2008 Sep |
|
| Mechanisms of action of antipsychotic drugs of different classes, refractoriness to therapeutic effects of classical neuroleptics, and individual variation in sensitivity to their actions: Part II. | 2009 Dec |
|
| Fatalities associated with clozapine-related constipation and bowel obstruction: a literature review and two case reports. | 2009 Jul-Aug |
|
| Trends in the molecular pathogenesis and clinical therapeutics of common neurodegenerative disorders. | 2009 Jun 3 |
|
| Physiological and pathological role of alpha-synuclein in Parkinson's disease through iron mediated oxidative stress; the role of a putative iron-responsive element. | 2009 Mar |
|
| Selective T-type calcium channel blockade alleviates hyperalgesia in ob/ob mice. | 2009 Nov |
|
| Acute dystonic reactions in a lady presenting with repetitive involuntary muscle twitching: a case report. | 2009 Nov 9 |
|
| Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method. | 2010 Dec |
|
| Identification of neuronal target areas for nerve agents and specification of receptors for pharmacological treatment. | 2010 Dec |
|
| Roles of perirhinal and posterior piriform cortices in control and generation of seizures: a microinfusion study in rats exposed to soman. | 2010 Jan |
|
| The use of organotypic hippocampal slice cultures to evaluate protection by non-competitive NMDA receptor antagonists against excitotoxicity. | 2010 Mar |
|
| Ethanol extract of Angelica gigas inhibits croton oil-induced inflammation by suppressing the cyclooxygenase - prostaglandin pathway. | 2010 Mar |
|
| Behavioral side effects in rats treated with acetylcholinesterase inhibitors suggested used as prophylactics against nerve agents. | 2010 May |
|
| Structured relaxation in the treatment of akathisia: case series. | 2010 May 25 |
|
| Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. | 2011 Jul 14 |
|
| Two medical therapies very effective shortly after high levels of soman poisoning in rats, but only one with universal utility. | 2013 Dec 15 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 01:34:32 UTC 2023
by
admin
on
Sat Dec 16 01:34:32 UTC 2023
|
| Record UNII |
THH8Q65426
|
| Record Status |
Validated (UNII)
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| Record Version |
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-
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| Code System | Code | Type | Description | ||
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22514
Created by
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8448
Created by
admin on Sat Dec 16 01:34:33 UTC 2023 , Edited by admin on Sat Dec 16 01:34:33 UTC 2023
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PRIMARY | |||
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THH8Q65426
Created by
admin on Sat Dec 16 01:34:33 UTC 2023 , Edited by admin on Sat Dec 16 01:34:33 UTC 2023
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PRIMARY | |||
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60-48-0
Created by
admin on Sat Dec 16 01:34:33 UTC 2023 , Edited by admin on Sat Dec 16 01:34:33 UTC 2023
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SALT/SOLVATE -> PARENT | |||
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ENANTIOMER -> RACEMATE | |||
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SALT/SOLVATE -> PARENT | |||
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ENANTIOMER -> RACEMATE | |||
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SALT/SOLVATE -> PARENT | |||
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SALT/SOLVATE -> PARENT |
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ACTIVE MOIETY |
