EPIDERMAL GROWTH FACTOR RECEPTOR (EXON 19 DELETION/T790M MUTANT)

Approval Year

Substance Class	Protein
Protein Type	RECEPTOR
Protein Sub Type	GROWTH FACTOR RECEPTOR
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	HRV48Z6HOP
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

EGFR EXON19DEL/T790M

Preferred Name

English

EPIDERMAL GROWTH FACTOR RECEPTOR (EXON 19 DELETION/T790M MUTANT)

Common Name

English

HER1 (E746-A750 DELETION/T790M)

Common Name

English

EGFR DEL19/T790M

Common Name

English

EPIDERMAL GROWTH FACTOR RECEPTOR (EXON 19 DELETION, L790M MUTANT)

Common Name

English

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Code System

Code

Type

Description

UNIPROT

P00533

PRIMARY

FDA UNII

HRV48Z6HOP

PRIMARY

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Subunit 0

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From	To
1_7	1_34
1_133	1_163
1_166	1_175
1_170	1_183
1_191	1_199

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Glycosylation Type

HUMAN

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Glycosylation Link Type	Site
N	1_32
N	1_49
N	1_104
N	1_151
N	1_172

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NAQUOTINIB

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Structural Modifications

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Modification Type	Location Site	Location Type	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_654]	SITE_SPECIFIC	THREONINE PHOSPHATE	3L4WX7B1EI
AMINO ACID SUBSTITUTION	[1_1170]	SITE_SPECIFIC	TILARGININE	27JT06E6GR
AMINO ACID SUBSTITUTION	[1_969] [1_987] [1_1063] [1_1081] [1_1143] [1_1168]		TYROSINE O-PHOSPHATE	2R86C98KDX

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Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT	CHEMICAL
Molecular Formula	CHEMICAL	ESTIMATED C5754H9033N1608O1778P7S84

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