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Details

Stereochemistry ABSOLUTE
Molecular Formula C18H19NO3.ClH
Molecular Weight 333.809
Optical Activity UNSPECIFIED
Defined Stereocenters 3 / 3
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ORIPAVINE HYDROCHLORIDE

SMILES

Cl.COC1=CC=C2[C@H]3CC4=CC=C(O)C5=C4[C@@]2(CCN3C)[C@H]1O5

InChI

InChIKey=OGVCGIJVSVSIEL-HIMTYSBHSA-N
InChI=1S/C18H19NO3.ClH/c1-19-8-7-18-11-4-6-14(21-2)17(18)22-16-13(20)5-3-10(15(16)18)9-12(11)19;/h3-6,12,17,20H,7-9H2,1-2H3;1H/t12-,17+,18+;/m1./s1

HIDE SMILES / InChI

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C18H19NO3
Molecular Weight 297.3484
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 3 / 3
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

PubMed

PubMed

TitleDatePubMed
N-demethylation of N-methyl alkaloids with ferrocene.
2010-08-01
No hyperalgesia following opioid withdrawal after the oripavine derivative etorphine compared to remifentanil and sufentanil.
2010-02
Biochemistry and occurrence of o-demethylation in plant metabolism.
2010
Isolation and identification of unique marker compounds from the Tasmanian poppy Papaver somniferum N. Implications for the identification of illicit heroin of Tasmanian origin.
2008-03-05
Differentiation of opium and poppy straw using capillary electrophoresis and pattern recognition techniques.
2007-12-12
Cinnamoyl derivatives of 7alpha-aminomethyl-6,14-endo-ethanotetrahydrothebaine and 7alpha-aminomethyl-6,14-endo-ethanotetrahydrooripavine and related opioid ligands.
2007-10-18
A hybrid FIA/HPLC system incorporating monolithic column chromatography.
2007-09-26
Designation of oripavine as a basic class of controlled substance. Final rule.
2007-09-24
Live cell monitoring of mu-opioid receptor-mediated G-protein activation reveals strong biological activity of close morphine biosynthetic precursors.
2007-09-14
Rapid determination of Papaver somniferum alkaloids in process streams using monolithic column high-performance liquid chromatography with chemiluminescence detection.
2007-07-30
Thienorphine: receptor binding and behavioral effects in rhesus monkeys.
2007-04
Determination of opiate alkaloids in process liquors using capillary electrophoresis.
2007-02-19
WHO Expert Committee on Drug Dependence.
2006
A rapid and reliable solid-phase extraction method for high-performance liquid chromatographic analysis of opium alkaloids from papaver plants.
2005-11
Submolecular partitioning of morphine hydrate based on its experimental charge density at 25 K.
2005-08
BU74, a complex oripavine derivative with potent kappa opioid receptor agonism and delayed opioid antagonism.
2005-02-21
RNAi-mediated replacement of morphine with the nonnarcotic alkaloid reticuline in opium poppy.
2004-12
Analgesia: morphine-pathway block in top1 poppies.
2004-09-23
Separation of opiate alkaloids by electrokinetic chromatography with sulfated-cyclodextrin as a pseudo-stationary phase.
2003-01-24
Characterization of opiates, neuroleptics, and synthetic analogs at ORL1 and opioid receptors.
2001-09-28
Comparison of pharmacological activities of buprenorphine and norbuprenorphine: norbuprenorphine is a potent opioid agonist.
2001-05
Patents
Substance Class Chemical
Created
by admin
on Mon Mar 31 23:16:03 GMT 2025
Edited
by admin
on Mon Mar 31 23:16:03 GMT 2025
Record UNII
HRR7PQ2JHN
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ORIPAVINE HYDROCHLORIDE
Common Name English
MORPHINAN-3-OL, 6,7,8,14-TETRADEHYDRO-4,5-EPOXY-6-METHOXY-17-METHYL-, HYDROCHLORIDE (1:1), (5.ALPHA.)-
Preferred Name English
MORPHINAN-3-OL, 6,7,8,14-TETRADEHYDRO-4,5.ALPHA.-EPOXY-6-METHOXY-17-METHYL-, HYDROCHLORIDE
Systematic Name English
MORPHINAN-3-OL, 6,7,8,14-TETRADEHYDRO-4,5-EPOXY-6-METHOXY-17-METHYL-, HYDROCHLORIDE, (5.ALPHA.)-
Systematic Name English
(4R,7AR,12BS)-7-METHOXY-3-METHYL-2,4,7A,13-TETRAHYDRO-1H-4,12-METHANOBENZOFURO(3,2-E)ISOQUINOLIN-9-OL;HYDROCHLORIDE
Systematic Name English
Code System Code Type Description
FDA UNII
HRR7PQ2JHN
Created by admin on Mon Mar 31 23:16:03 GMT 2025 , Edited by admin on Mon Mar 31 23:16:03 GMT 2025
PRIMARY
CAS
6153-40-8
Created by admin on Mon Mar 31 23:16:03 GMT 2025 , Edited by admin on Mon Mar 31 23:16:03 GMT 2025
PRIMARY
PUBCHEM
66760524
Created by admin on Mon Mar 31 23:16:03 GMT 2025 , Edited by admin on Mon Mar 31 23:16:03 GMT 2025
PRIMARY
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