SINTROPIUM BROMIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H36NO2.Br
Molecular Weight	390.399
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Br-].CCCC(CCC)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)[N@+]2(C)C(C)C

InChI

InChIKey=MOOADSDJJYWLMR-WIYVAMDUSA-M

InChI=1S/C19H36NO2.BrH/c1-6-8-15(9-7-2)19(21)22-18-12-16-10-11-17(13-18)20(16,5)14(3)4;/h14-18H,6-13H2,1-5H3;1H/q+1;/p-1/t16-,17+,18+,20?;

HIDE SMILES / InChI

Molecular Formula	BrH
Molecular Weight	80.912
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C19H36NO2
Molecular Weight	310.4946
Charge	1
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	2 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://adisinsight.springer.com/drugs/800003574 | https://www.ncbi.nlm.nih.gov/pubmed/3900811

Sintropium [VAL 480] is a gastrointestinal, biliary and urinary spasmolytic agent that was under development with Valeas in Italy. It is a muscarinic receptor antagonist. Sintropium bromide has a prompt anticholinergic action and for this reason may be used in the treatment of painful conditions of the bile, gastro-enteric and renal tracts, and also during the course of endoscopic examinations.

Originator

Approval Year

PubMed

Title	Date	PubMed
[Sintropium bromide (VAL 480): a new spasmolytic agent in general surgery].	1986 Oct 15	3808371

Patents

Sample Use Guides

In Vivo Use Guide

LD50 i.p. in male mice: 77 mg/kg

Route of Administration: Intraperitoneal

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:19:55 GMT 2023` Edited by `admin` on `Fri Dec 15 18:19:55 GMT 2023`
Record UNII	HR77ZB839G
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SINTROPIUM BROMIDE

Official Name

English

VAL-4000

Code

English

SINTROPIUM BROMIDE [MI]

Common Name

English

sintropium bromide [INN]

Common Name

English

VAL-480

Code

English

3.ALPHA.-HYDROXY-8-ISOPROPYL-1.ALPHA.H,5.ALPHA.H-TROPANIUM BROMIDE 2-PROPYLVALERATE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29698