U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Thu Jul 06 19:35:56 UTC 2023
Edited
by admin
on Thu Jul 06 19:35:56 UTC 2023
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
HR6E2AWX74
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PROTEIN CEREBLON
Common Name English
CRBN
Common Name English
Code System Code Type Description
UNIPROT
Q96SW2
Created by admin on Thu Jul 06 19:35:57 UTC 2023 , Edited by admin on Thu Jul 06 19:35:57 UTC 2023
PRIMARY
FDA UNII
HR6E2AWX74
Created by admin on Thu Jul 06 19:35:57 UTC 2023 , Edited by admin on Thu Jul 06 19:35:57 UTC 2023
PRIMARY
Related Record Type Details
LIGAND->TARGET
CRBN ubiquitination studies in the transfected HEK293T cells resulted in the following potencies: CC-220 IC50 = 0.19 μM; lenalidomide IC50 = 12.9 μM; and pomalidomide IC50 = 21.6 μM.
BINDING
IC50
INHIBITOR -> TARGET
MODULATOR->TARGET
INDUCER -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
LIGAND->TARGET
IN-VITRO
MODULATOR->TARGET
INHIBITOR -> TARGET
LIGAND->TARGET
MODULATOR->TARGET
LIGAND->TARGET
Kd
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL