Details
| Stereochemistry | EPIMERIC |
| Molecular Formula | C44H49F2N11O6 |
| Molecular Weight | 865.9268 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 5 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN1C(=O)N(C2CCC(=O)NC2=O)C3=C1C(=CC=C3)C#CCOC4CCN(C[C@H]5CC[C@@H](CC5)N6C=C(NC(=O)C7=C8N=C(C=CN8N=C7)N9C[C@H]%10C[C@@H]9CO%10)C(=N6)C(F)F)CC4
InChI
InChIKey=NQGKNAVUMAHSQN-KDRPOVOJSA-N
InChI=1S/C44H49F2N11O6/c1-52-39-27(4-2-6-34(39)57(44(52)61)35-11-12-37(58)50-43(35)60)5-3-19-62-30-13-16-53(17-14-30)22-26-7-9-28(10-8-26)56-24-33(38(51-56)40(45)46)48-42(59)32-21-47-55-18-15-36(49-41(32)55)54-23-31-20-29(54)25-63-31/h2,4,6,15,18,21,24,26,28-31,35,40H,7-14,16-17,19-20,22-23,25H2,1H3,(H,48,59)(H,50,58,60)/t26-,28-,29-,31-,35?/m1/s1
| Molecular Formula | C44H49F2N11O6 |
| Molecular Weight | 865.9268 |
| Charge | 0 |
| Count |
|
| Stereochemistry | EPIMERIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 4 / 5 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Wed Apr 02 09:27:26 GMT 2025
by
admin
on
Wed Apr 02 09:27:26 GMT 2025
|
| Record UNII |
2SXR65P7E3
|
| Record Status |
Validated (UNII)
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| Record Version |
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-
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| Code System | Code | Type | Description | ||
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2432994-31-3
Created by
admin on Wed Apr 02 09:27:26 GMT 2025 , Edited by admin on Wed Apr 02 09:27:26 GMT 2025
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300000050941
Created by
admin on Wed Apr 02 09:27:26 GMT 2025 , Edited by admin on Wed Apr 02 09:27:26 GMT 2025
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PRIMARY | |||
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2SXR65P7E3
Created by
admin on Wed Apr 02 09:27:26 GMT 2025 , Edited by admin on Wed Apr 02 09:27:26 GMT 2025
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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TARGET->DEGRADER |
KT-474 is a targeting IRAK4 and the E3 ligase CRBN to mediate the selective degradation of IRAK4 via the ubiquitin-proteasome system (UPS)
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TARGET->LIGAND |
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| Related Record | Type | Details | ||
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ACTIVE MOIETY |
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