MEBANAZINE OXALATE

Details

Stereochemistry	RACEMIC
Molecular Formula	C8H12N2.C2H2O4
Molecular Weight	226.2292
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)C(O)=O.CC(NN)C1=CC=CC=C1

InChI

InChIKey=ZJHCOEKEFDUTPX-UHFFFAOYSA-N

InChI=1S/C8H12N2.C2H2O4/c1-7(10-9)8-5-3-2-4-6-8;3-1(4)2(5)6/h2-7,10H,9H2,1H3;(H,3,4)(H,5,6)

HIDE SMILES / InChI

Molecular Formula	C8H12N2
Molecular Weight	136.1943
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Molecular Formula	C2H2O4
Molecular Weight	90.0349
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/25174932 | https://www.ncbi.nlm.nih.gov/pubmed/5320546 | https://www.ncbi.nlm.nih.gov/pubmed/4392571

Mebanazine is an inhibitor of monoamine oxidase. It was introduced in the 1960s for the treatment of depression and was marketed under trade name Actomol. The drug was withdrawn from the market due to hepatotoxicity. In addition to its antidepressant effect, the drug was found to possess an anorexic action and in animal models, it potentiated the hypoglycemic response to insulin and delayed the recovery of blood glucose levels to normal.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Monoamine oxidase 32 Target ID: CHEMBL2095205 Sources: https://www.ncbi.nlm.nih.gov/pubmed/5889715	Inhibitor 8504

PubMed

Title	Date	PubMed
Contribution of sleep research to the development of new antidepressants.	2005	16416706
A preliminary trial of mebanazine in depressive states.	1965-11-01	5327282
A controlled trial of mebanazine ('Actomol') in depression.	1965-11	5320546
Clinical trial of mebanazine--a new monoamine oxidase inhibitor.	1965-09	5889715

Substance Class	Chemical Created by `admin` on `Mon Mar 31 22:20:11 GMT 2025` Edited by `admin` on `Mon Mar 31 22:20:11 GMT 2025`
Record UNII	HQ89TG9D9S
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MEBANAZINE OXALATE

Common Name

English

NSC-104084

Preferred Name

English

HYDRAZINE, (1-PHENYLETHYL)-, ETHANEDIOATE

Systematic Name

English

HYDRAZINE, (.ALPHA.-METHYLBENZYL)-, OXALATE

Systematic Name

English

HYDRAZINE, .ALPHA.-(.ALPHA.-METHYLBENZYL)-, OXALATE

Systematic Name

English

Z-87

Code

English

.ALPHA.-PHENYLETHYLHYDRAZINE OXALATE (1:1)

Systematic Name

English

HYDRAZINE, (1-PHENYLETHYL)-, ETHANEDIOATE (1:1)

Systematic Name

English

Code System Code Type Description

EPA CompTox

DTXSID00943680