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Details

Stereochemistry RACEMIC
Molecular Formula C21H23N3O2.C3H6O3
Molecular Weight 439.5051
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 1
Charge 0
Stereo Comments C3H603

SHOW SMILES / InChI
Structure of PANOBINOSTAT LACTATE

SMILES

Cc1c(CCNCc2ccc(cc2)/C(/[H])=C(\[H])/C(=NO)O)c3ccccc3[nH]1.CC(C(=O)O)O

InChI

InChIKey=XVDWNSFFSMWXJJ-ASTDGNLGSA-N
InChI=1S/C21H23N3O2.C3H6O3/c1-15-18(19-4-2-3-5-20(19)23-15)12-13-22-14-17-8-6-16(7-9-17)10-11-21(25)24-26;1-2(4)3(5)6/h2-11,22-23,26H,12-14H2,1H3,(H,24,25);2,4H,1H3,(H,5,6)/b11-10+;

HIDE SMILES / InChI

Molecular Formula C21H23N3O2
Molecular Weight 349.427
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Molecular Formula C3H6O3
Molecular Weight 90.0781
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description
Curator's Comment:: Description was created based on several sources, including https://www.drugbank.ca/drugs/DB06603

Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress of being conducted. Panobinostat is marketed by Novartis under the brand name Farydak. Panobinostat is a deacetylase (DAC) inhibitor. DACs, also known as histone DACs (HDAC), are responsible for regulating the acetylation of about 1750 proteins in the body; their functions are involved in many biological processes including DNA replication and repair, chromatin remodelling, transcription of genes, progression of the cell-cycle, protein degradation and cytoskeletal reorganization. In multiple myeloma, there is an overexpression of DAC proteins. Panobinostat inhibits class I (HDACs 1, 2, 3, 8), class II (HDACs 4, 5, 6, 7, 9, 10) and class IV (HDAC 11) proteins. Panobinostat's antitumor activity is believed to be attributed to epigenetic modulation of gene expression and inhibition of protein metabolism. Panobinostat also exhibits cytotoxic synergy with bortezomib, a proteasome inhibitor concurrently used in treatment of multiple myeloma.

Originator

Curator's Comment:: # Novartis

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
280.0 nM [IC50]
11.0 nM [IC50]
2.1 nM [IC50]
13.0 nM [IC50]
2.5 nM [IC50]
200.0 nM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
FARYDAK

Approved Use

FARYDAK, a histone deacetylase inhibitor, in combination with bortezomib and dexamethasone, is indicated for the treatment of patients with multiple myeloma who have received at least 2 prior regimens, including bortezomib and an immunomodulatory agent

Launch Date

1.42456324E12
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
15.3 ng/mL
20 mg 1 times / day multiple, oral
dose: 20 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered: BORTEZOMIB
PANOBINOSTAT plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
95.2 ng × h/mL
20 mg 1 times / day multiple, oral
dose: 20 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered: BORTEZOMIB
PANOBINOSTAT plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
16.7 h
20 mg 1 times / day multiple, oral
dose: 20 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered: BORTEZOMIB
PANOBINOSTAT plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
10%
PANOBINOSTAT plasma
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
34 mg/m2 3 times / week multiple, oral
Highest studied dose|RP2D
Dose: 34 mg/m2, 3 times / week
Route: oral
Route: multiple
Dose: 34 mg/m2, 3 times / week
Sources:
unhealthy, 1-21 years
n = 11
Health Status: unhealthy
Condition: relapsed and refractory hematologic malignancies
Age Group: 1-21 years
Sex: M+F
Population Size: 11
Sources:
DLT: Hypertriglyceridemia...
Dose limiting toxicities:
Hypertriglyceridemia (grade 4, 1 patient)
Sources:
15 mg/m2 1 times / week multiple, intravenous (starting)
Dose: 15 mg/m2, 1 times / week
Route: intravenous
Route: multiple
Dose: 15 mg/m2, 1 times / week
Sources:
unhealthy, 3-17 years
n = 9
Health Status: unhealthy
Condition: refractory solid tumors
Age Group: 3-17 years
Sex: M+F
Population Size: 9
Sources:
DLT: Electrocardiogram T wave abnormal...
Dose limiting toxicities:
Electrocardiogram T wave abnormal (2 patients)
Sources:
20 mg 3 times / week multiple, oral
Recommended|MTD
Dose: 20 mg, 3 times / week
Route: oral
Route: multiple
Dose: 20 mg, 3 times / week
Co-administed with::
bortezomib(1.3 mg/m2)
dexamethasone
Sources: Page: p. 36, 45
unhealthy, 60 years (range: 28-79 years)
n = 386
Health Status: unhealthy
Age Group: 60 years (range: 28-79 years)
Sex: M+F
Population Size: 386
Sources: Page: p. 36, 45
Disc. AE: Diarrhea, Thrombocytopenia...
AEs leading to
discontinuation/dose reduction:
Diarrhea (17 patients)
Thrombocytopenia (6 patients)
Fatigue (11 patient)
Asthenia (11 patient)
Peripheral neuropathy (14 patients)
Thrombocytopenia (28%)
Sources: Page: p. 36, 45
20 mg/m2 1 times / week multiple, intravenous
Highest studied dose
Dose: 20 mg/m2, 1 times / week
Route: intravenous
Route: multiple
Dose: 20 mg/m2, 1 times / week
Sources:
unhealthy, 63.0 years (range: 43–75 years)
n = 8
Health Status: unhealthy
Condition: advanced solid tumors
Age Group: 63.0 years (range: 43–75 years)
Sex: M+F
Population Size: 8
Sources:
DLT: Gamma glutamyl transpeptidase increased...
Other AEs: Thrombocytopenia, Leukopenia...
Dose limiting toxicities:
Gamma glutamyl transpeptidase increased (grade 3, 1 patient)
Other AEs:
Thrombocytopenia (grade 3-4, 2 patients)
Leukopenia (grade 3-4, 2 patients)
Neutropenia (grade 3-4, 5 patients)
Nausea (grade 1-2, 4 patients)
Stomatitis (grade 1-2, 3 patients)
Vomiting (grade 1-2, 3 patients)
Fatigue (grade 3-4, 1 patient)
Fever (grade 1-2, 4 patients)
Decreased appetite (grade 1-2, 5 patients)
Hypoalbuminemia (grade 1-2, 2 patients)
Rash (grade 1-2, 3 patients)
Sources:
20 mg 3 times / week multiple, oral
Recommended|MTD
Dose: 20 mg, 3 times / week
Route: oral
Route: multiple
Dose: 20 mg, 3 times / week
Sources:
unhealthy
Other AEs: Diarrhea, Arrhythmia...
Other AEs:
Diarrhea (severe|grade 5, 25%)
Arrhythmia (severe)
Sources:
AEs

AEs

AESignificanceDosePopulation
Hypertriglyceridemia grade 4, 1 patient
DLT
34 mg/m2 3 times / week multiple, oral
Highest studied dose|RP2D
Dose: 34 mg/m2, 3 times / week
Route: oral
Route: multiple
Dose: 34 mg/m2, 3 times / week
Sources:
unhealthy, 1-21 years
n = 11
Health Status: unhealthy
Condition: relapsed and refractory hematologic malignancies
Age Group: 1-21 years
Sex: M+F
Population Size: 11
Sources:
Electrocardiogram T wave abnormal 2 patients
DLT
15 mg/m2 1 times / week multiple, intravenous (starting)
Dose: 15 mg/m2, 1 times / week
Route: intravenous
Route: multiple
Dose: 15 mg/m2, 1 times / week
Sources:
unhealthy, 3-17 years
n = 9
Health Status: unhealthy
Condition: refractory solid tumors
Age Group: 3-17 years
Sex: M+F
Population Size: 9
Sources:
Asthenia 11 patient
Disc. AE
20 mg 3 times / week multiple, oral
Recommended|MTD
Dose: 20 mg, 3 times / week
Route: oral
Route: multiple
Dose: 20 mg, 3 times / week
Co-administed with::
bortezomib(1.3 mg/m2)
dexamethasone
Sources: Page: p. 36, 45
unhealthy, 60 years (range: 28-79 years)
n = 386
Health Status: unhealthy
Age Group: 60 years (range: 28-79 years)
Sex: M+F
Population Size: 386
Sources: Page: p. 36, 45
Fatigue 11 patient
Disc. AE
20 mg 3 times / week multiple, oral
Recommended|MTD
Dose: 20 mg, 3 times / week
Route: oral
Route: multiple
Dose: 20 mg, 3 times / week
Co-administed with::
bortezomib(1.3 mg/m2)
dexamethasone
Sources: Page: p. 36, 45
unhealthy, 60 years (range: 28-79 years)
n = 386
Health Status: unhealthy
Age Group: 60 years (range: 28-79 years)
Sex: M+F
Population Size: 386
Sources: Page: p. 36, 45
Peripheral neuropathy 14 patients
Disc. AE
20 mg 3 times / week multiple, oral
Recommended|MTD
Dose: 20 mg, 3 times / week
Route: oral
Route: multiple
Dose: 20 mg, 3 times / week
Co-administed with::
bortezomib(1.3 mg/m2)
dexamethasone
Sources: Page: p. 36, 45
unhealthy, 60 years (range: 28-79 years)
n = 386
Health Status: unhealthy
Age Group: 60 years (range: 28-79 years)
Sex: M+F
Population Size: 386
Sources: Page: p. 36, 45
Diarrhea 17 patients
Disc. AE
20 mg 3 times / week multiple, oral
Recommended|MTD
Dose: 20 mg, 3 times / week
Route: oral
Route: multiple
Dose: 20 mg, 3 times / week
Co-administed with::
bortezomib(1.3 mg/m2)
dexamethasone
Sources: Page: p. 36, 45
unhealthy, 60 years (range: 28-79 years)
n = 386
Health Status: unhealthy
Age Group: 60 years (range: 28-79 years)
Sex: M+F
Population Size: 386
Sources: Page: p. 36, 45
Thrombocytopenia 28%
Disc. AE
20 mg 3 times / week multiple, oral
Recommended|MTD
Dose: 20 mg, 3 times / week
Route: oral
Route: multiple
Dose: 20 mg, 3 times / week
Co-administed with::
bortezomib(1.3 mg/m2)
dexamethasone
Sources: Page: p. 36, 45
unhealthy, 60 years (range: 28-79 years)
n = 386
Health Status: unhealthy
Age Group: 60 years (range: 28-79 years)
Sex: M+F
Population Size: 386
Sources: Page: p. 36, 45
Thrombocytopenia 6 patients
Disc. AE
20 mg 3 times / week multiple, oral
Recommended|MTD
Dose: 20 mg, 3 times / week
Route: oral
Route: multiple
Dose: 20 mg, 3 times / week
Co-administed with::
bortezomib(1.3 mg/m2)
dexamethasone
Sources: Page: p. 36, 45
unhealthy, 60 years (range: 28-79 years)
n = 386
Health Status: unhealthy
Age Group: 60 years (range: 28-79 years)
Sex: M+F
Population Size: 386
Sources: Page: p. 36, 45
Hypoalbuminemia grade 1-2, 2 patients
20 mg/m2 1 times / week multiple, intravenous
Highest studied dose
Dose: 20 mg/m2, 1 times / week
Route: intravenous
Route: multiple
Dose: 20 mg/m2, 1 times / week
Sources:
unhealthy, 63.0 years (range: 43–75 years)
n = 8
Health Status: unhealthy
Condition: advanced solid tumors
Age Group: 63.0 years (range: 43–75 years)
Sex: M+F
Population Size: 8
Sources:
Rash grade 1-2, 3 patients
20 mg/m2 1 times / week multiple, intravenous
Highest studied dose
Dose: 20 mg/m2, 1 times / week
Route: intravenous
Route: multiple
Dose: 20 mg/m2, 1 times / week
Sources:
unhealthy, 63.0 years (range: 43–75 years)
n = 8
Health Status: unhealthy
Condition: advanced solid tumors
Age Group: 63.0 years (range: 43–75 years)
Sex: M+F
Population Size: 8
Sources:
Stomatitis grade 1-2, 3 patients
20 mg/m2 1 times / week multiple, intravenous
Highest studied dose
Dose: 20 mg/m2, 1 times / week
Route: intravenous
Route: multiple
Dose: 20 mg/m2, 1 times / week
Sources:
unhealthy, 63.0 years (range: 43–75 years)
n = 8
Health Status: unhealthy
Condition: advanced solid tumors
Age Group: 63.0 years (range: 43–75 years)
Sex: M+F
Population Size: 8
Sources:
Vomiting grade 1-2, 3 patients
20 mg/m2 1 times / week multiple, intravenous
Highest studied dose
Dose: 20 mg/m2, 1 times / week
Route: intravenous
Route: multiple
Dose: 20 mg/m2, 1 times / week
Sources:
unhealthy, 63.0 years (range: 43–75 years)
n = 8
Health Status: unhealthy
Condition: advanced solid tumors
Age Group: 63.0 years (range: 43–75 years)
Sex: M+F
Population Size: 8
Sources:
Fever grade 1-2, 4 patients
20 mg/m2 1 times / week multiple, intravenous
Highest studied dose
Dose: 20 mg/m2, 1 times / week
Route: intravenous
Route: multiple
Dose: 20 mg/m2, 1 times / week
Sources:
unhealthy, 63.0 years (range: 43–75 years)
n = 8
Health Status: unhealthy
Condition: advanced solid tumors
Age Group: 63.0 years (range: 43–75 years)
Sex: M+F
Population Size: 8
Sources:
Nausea grade 1-2, 4 patients
20 mg/m2 1 times / week multiple, intravenous
Highest studied dose
Dose: 20 mg/m2, 1 times / week
Route: intravenous
Route: multiple
Dose: 20 mg/m2, 1 times / week
Sources:
unhealthy, 63.0 years (range: 43–75 years)
n = 8
Health Status: unhealthy
Condition: advanced solid tumors
Age Group: 63.0 years (range: 43–75 years)
Sex: M+F
Population Size: 8
Sources:
Decreased appetite grade 1-2, 5 patients
20 mg/m2 1 times / week multiple, intravenous
Highest studied dose
Dose: 20 mg/m2, 1 times / week
Route: intravenous
Route: multiple
Dose: 20 mg/m2, 1 times / week
Sources:
unhealthy, 63.0 years (range: 43–75 years)
n = 8
Health Status: unhealthy
Condition: advanced solid tumors
Age Group: 63.0 years (range: 43–75 years)
Sex: M+F
Population Size: 8
Sources:
Gamma glutamyl transpeptidase increased grade 3, 1 patient
DLT
20 mg/m2 1 times / week multiple, intravenous
Highest studied dose
Dose: 20 mg/m2, 1 times / week
Route: intravenous
Route: multiple
Dose: 20 mg/m2, 1 times / week
Sources:
unhealthy, 63.0 years (range: 43–75 years)
n = 8
Health Status: unhealthy
Condition: advanced solid tumors
Age Group: 63.0 years (range: 43–75 years)
Sex: M+F
Population Size: 8
Sources:
Fatigue grade 3-4, 1 patient
20 mg/m2 1 times / week multiple, intravenous
Highest studied dose
Dose: 20 mg/m2, 1 times / week
Route: intravenous
Route: multiple
Dose: 20 mg/m2, 1 times / week
Sources:
unhealthy, 63.0 years (range: 43–75 years)
n = 8
Health Status: unhealthy
Condition: advanced solid tumors
Age Group: 63.0 years (range: 43–75 years)
Sex: M+F
Population Size: 8
Sources:
Leukopenia grade 3-4, 2 patients
20 mg/m2 1 times / week multiple, intravenous
Highest studied dose
Dose: 20 mg/m2, 1 times / week
Route: intravenous
Route: multiple
Dose: 20 mg/m2, 1 times / week
Sources:
unhealthy, 63.0 years (range: 43–75 years)
n = 8
Health Status: unhealthy
Condition: advanced solid tumors
Age Group: 63.0 years (range: 43–75 years)
Sex: M+F
Population Size: 8
Sources:
Thrombocytopenia grade 3-4, 2 patients
20 mg/m2 1 times / week multiple, intravenous
Highest studied dose
Dose: 20 mg/m2, 1 times / week
Route: intravenous
Route: multiple
Dose: 20 mg/m2, 1 times / week
Sources:
unhealthy, 63.0 years (range: 43–75 years)
n = 8
Health Status: unhealthy
Condition: advanced solid tumors
Age Group: 63.0 years (range: 43–75 years)
Sex: M+F
Population Size: 8
Sources:
Neutropenia grade 3-4, 5 patients
20 mg/m2 1 times / week multiple, intravenous
Highest studied dose
Dose: 20 mg/m2, 1 times / week
Route: intravenous
Route: multiple
Dose: 20 mg/m2, 1 times / week
Sources:
unhealthy, 63.0 years (range: 43–75 years)
n = 8
Health Status: unhealthy
Condition: advanced solid tumors
Age Group: 63.0 years (range: 43–75 years)
Sex: M+F
Population Size: 8
Sources:
Arrhythmia severe
20 mg 3 times / week multiple, oral
Recommended|MTD
Dose: 20 mg, 3 times / week
Route: oral
Route: multiple
Dose: 20 mg, 3 times / week
Sources:
unhealthy
Diarrhea severe|grade 5, 25%
20 mg 3 times / week multiple, oral
Recommended|MTD
Dose: 20 mg, 3 times / week
Route: oral
Route: multiple
Dose: 20 mg, 3 times / week
Sources:
unhealthy
OverviewDrug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
no [IC50 >100 uM]
no [IC50 >100 uM]
no [IC50 >100 uM]
no [IC50 >100 uM]
no
no
no
no
no
no
no
no
no
no
unlikely
unlikely
unlikely
weak
weak
weak
yes [IC50 2 uM]
yes (co-administration study)
Comment: The coadministration of a single 60 mg dextromethorphan (DM) dose with FARYDAK (20 mg once per day, on Days 3, 5, and 8) increased the Cmax and AUC0-¥ of DM by 20% to 200% (interquartile range)and 20% to 130% (interquartile range), respectively
Page: 28.0
yes
yes
yes
yes
yes
Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
major
yes (co-administration study)
Comment: In an in vivo evaluation, coadministration of a single 20 mg FARYDAK dose with the strong CYP3A4 inhibitor ketoconazole (200 mg twice daily for 14 days) increased the Cmax and AUC0-48 of PAN by 67% and 73% respectively
Page: 27.0
no
no
yes [Km >100 uM]
yes
yes
yes
yes
yes
yes
yes
yes
Tox targets
PubMed

PubMed

TitleDatePubMed
Targeting tumor angiogenesis with histone deacetylase inhibitors: the hydroxamic acid derivative LBH589.
2006 Jan 15
Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors.
2008 Jan 15
Mitochondrial Bax translocation partially mediates synergistic cytotoxicity between histone deacetylase inhibitors and proteasome inhibitors in glioma cells.
2008 Jun
A systematic assessment of radiation dose enhancement by 5-Aza-2'-deoxycytidine and histone deacetylase inhibitors in head-and-neck squamous cell carcinoma.
2009 Mar 1
To selectivity and beyond.
2010 Dec
Induction of TAp63 by histone deacetylase inhibitors.
2010 Jan 22
Discovery of (2E)-3-{2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile.
2011 Jul 14
Low-dose LBH589 increases the sensitivity of cisplatin to cisplatin-resistant ovarian cancer cells.
2011 Jun
Discovery, synthesis, and biological evaluation of novel SMN protein modulators.
2011 Sep 22
Resveratrol sensitizes acute myelogenous leukemia cells to histone deacetylase inhibitors through reactive oxygen species-mediated activation of the extrinsic apoptotic pathway.
2012 Dec
SIRT1 activation enhances HDAC inhibition-mediated upregulation of GADD45G by repressing the binding of NF-κB/STAT3 complex to its promoter in malignant lymphoid cells.
2013 May 16
Highly active combination of BRD4 antagonist and histone deacetylase inhibitor against human acute myelogenous leukemia cells.
2014 May
Panobinostat for the Treatment of Multiple Myeloma.
2015 Nov 1
A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors.
2015 Sep
The Bromodomain Inhibitor JQ1 and the Histone Deacetylase Inhibitor Panobinostat Synergistically Reduce N-Myc Expression and Induce Anticancer Effects.
2016 May 15
Patents

Sample Use Guides

20 mg, taken orally once every other day for 3 doses per week (on Days 1, 3, 5, 8, 10, and 12) of Weeks 1 and 2 of each 21-day cycle for 8 cycles
Route of Administration: Oral
Besides, Panobinostat inhibits growth of non small cell lung cancer cell lines (such as human H1299, L55 and A549 with IC50 of 5 nM, 11 nM and 30 nM, respectively), mesothelioma (such as human OK-6 and Ok-5 with IC50 of 5 nM and 7 nM, respectively) and small cell lung cancer cell lines (such as human RG-1 and LD-T with IC50 of 4 nM and 5 nM, respectively).
Substance Class Chemical
Created
by admin
on Fri Jun 25 23:52:38 UTC 2021
Edited
by admin
on Fri Jun 25 23:52:38 UTC 2021
Record UNII
HN0T99OO4V
Record Status Validated (UNII)
Record Version
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Name Type Language
PANOBINOSTAT LACTATE
JAN   WHO-DD  
Common Name English
PANOBINOSTAT LACTATE [JAN]
Common Name English
PANOBINOSTAT LACTATE [WHO-DD]
Common Name English
PANOBINOSTAT LACTATE [ORANGE BOOK]
Common Name English
PANOBINOSTAT LACTATE ANHYDROUS
Common Name English
FARYDAK
Brand Name English
PROPANOIC ACID, 2-HYDROXY-, COMPD. WITH (2E)-N-HYDROXY-3-(4-(((2-(2-METHYL-1H-INDOL-3-YL)ETHYL)AMINO)METHYL)PHENYL)-2-PROPENAMIDE (1:1)
Common Name English
(2E)-N-HYDROXY-3-(4-(((2-(2-METHYL-1H-INDOL-3-YL)ETHYL)AMINO(METHYL)PHENYL)PROP-2-ENAMIDE MONO((2RS)-2-HYDROXYPROPANOATE)
Common Name English
Classification Tree Code System Code
EMA ASSESSMENT REPORTS FARYDAK (AUTHORIZED: MULTIPLE MYELOMA)
Created by admin on Fri Jun 25 23:52:38 UTC 2021 , Edited by admin on Fri Jun 25 23:52:38 UTC 2021
EU-Orphan Drug EU/3/07/464
Created by admin on Fri Jun 25 23:52:38 UTC 2021 , Edited by admin on Fri Jun 25 23:52:38 UTC 2021
Code System Code Type Description
FDA UNII
HN0T99OO4V
Created by admin on Fri Jun 25 23:52:38 UTC 2021 , Edited by admin on Fri Jun 25 23:52:38 UTC 2021
PRIMARY
NCI_THESAURUS
C176044
Created by admin on Fri Jun 25 23:52:38 UTC 2021 , Edited by admin on Fri Jun 25 23:52:38 UTC 2021
PRIMARY
ChEMBL
CHEMBL483254
Created by admin on Fri Jun 25 23:52:38 UTC 2021 , Edited by admin on Fri Jun 25 23:52:38 UTC 2021
PRIMARY
JAPANESE REVIEW
FARYDAK
Created by admin on Fri Jun 25 23:52:38 UTC 2021 , Edited by admin on Fri Jun 25 23:52:38 UTC 2021
PRIMARY APPROVED JULY 2015
DRUG BANK
DBSALT001103
Created by admin on Fri Jun 25 23:52:38 UTC 2021 , Edited by admin on Fri Jun 25 23:52:38 UTC 2021
PRIMARY
PUBCHEM
23725423
Created by admin on Fri Jun 25 23:52:38 UTC 2021 , Edited by admin on Fri Jun 25 23:52:38 UTC 2021
PRIMARY
CAS
960055-56-5
Created by admin on Fri Jun 25 23:52:38 UTC 2021 , Edited by admin on Fri Jun 25 23:52:38 UTC 2021
PRIMARY
EVMPD
SUB166413
Created by admin on Fri Jun 25 23:52:38 UTC 2021 , Edited by admin on Fri Jun 25 23:52:38 UTC 2021
PRIMARY
RXCUI
1603349
Created by admin on Fri Jun 25 23:52:38 UTC 2021 , Edited by admin on Fri Jun 25 23:52:38 UTC 2021
PRIMARY RxNorm
Related Record Type Details
PARENT -> SALT/SOLVATE
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY