FAMPROFAZONE

Details

Stereochemistry	RACEMIC
Molecular Formula	C24H31N3O
Molecular Weight	377.5224
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(CC1=CC=CC=C1)N(C)CC2=C(C(C)C)C(=O)N(N2C)C3=CC=CC=C3

InChI

InChIKey=GNUXVOXXWGNPIV-UHFFFAOYSA-N

InChI=1S/C24H31N3O/c1-18(2)23-22(17-25(4)19(3)16-20-12-8-6-9-13-20)26(5)27(24(23)28)21-14-10-7-11-15-21/h6-15,18-19H,16-17H2,1-5H3

HIDE SMILES / InChI

Molecular Formula	C24H31N3O
Molecular Weight	377.5224
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/20663288 | https://www.ncbi.nlm.nih.gov/pubmed/9094203

Famprofazone, a nonsteroidal anti-inflammatory agent, is found in a multi-ingredient medication (Gewodin) used for pain relief. It is available over-the-counter in Taiwan. Famprofazone transforms to methamphetamine (MA) and amphetamine (AM) following administration, which is responsible for the side effects of the drug. For example, famprofazone user might be interpreted as an illicit MA abuser in Taiwan because the user's urine tested positive for MA.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pain 614 Sources: https://www.ncbi.nlm.nih.gov/pubmed/14607003	Palliative		Not Provided 504	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Toxicokinetics of amphetamines: metabolism and toxicokinetic data of designer drugs, amphetamine, methamphetamine, and their N-alkyl derivatives.	2002 Apr	11897973
Precursor medications as a source of methamphetamine and/or amphetamine positive drug testing results.	2002 May	12024689
Famprofazone as the source of methamphetamine and amphetamine in urine specimen collected during sport competition.	2007 Mar	17316255
Famprofazone use can be misinterpreted as methamphetamine abuse.	2010 Jul-Aug	20663288

Patents

Sample Use Guides

In Vivo Use Guide

25 mg once per day

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:56:57 GMT 2023` Edited by `admin` on `Fri Dec 15 15:56:57 GMT 2023`
Record UNII	HN0NCX453C
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FAMPROFAZONE

Official Name

English

FAMPROFAZONE [MART.]

Common Name

English

Famprofazone [WHO-DD]

Common Name

English

4-ISOPROPYL-2-METHYL-3-((METHYL(.ALPHA.-METHYLPHENETHYL)AMINO)METHYL)-1-PHENYL-3-PYRAZOLIN-5-ONE

Systematic Name

English

famprofazone [INN]

Common Name

English

NSC-759244

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C257