Details
Stereochemistry | ACHIRAL |
Molecular Formula | C14H13NO5 |
Molecular Weight | 275.2567 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)C1=CC(NCC2=CC(O)=CC=C2O)=CC=C1O
InChI
InChIKey=LULATDWLDJOKCX-UHFFFAOYSA-N
InChI=1S/C14H13NO5/c16-10-2-4-12(17)8(5-10)7-15-9-1-3-13(18)11(6-9)14(19)20/h1-6,15-18H,7H2,(H,19,20)
Molecular Formula | C14H13NO5 |
Molecular Weight | 275.2567 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Originator
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2614420
Curator's Comment: 1989
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL203 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8105084 |
4.0 µM [IC50] | ||
Target ID: CHEMBL258 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8105084 |
10.0 µM [IC50] | ||
Target ID: CHEMBL1824 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8105084 |
0.9 µM [IC50] | ||
Target ID: CHEMBL2097164 Sources: https://www.ncbi.nlm.nih.gov/pubmed/1656271 |
0.2 µM [IC50] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
PubMed
Title | Date | PubMed |
---|---|---|
Glycosphingolipid-enriched signaling domain in mouse neuroblastoma Neuro2a cells. Mechanism of ganglioside-dependent neuritogenesis. | 1999 Jul 23 |
|
Calcium/calmodulin-dependent protein kinase II phosphorylates and regulates the Drosophila eag potassium channel. | 2002 Jul 5 |
|
[Construction of a three-dimensional human angiogenesis model in vitro for antiangiogenic drug selection]. | 2004 Oct |
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Augmentation of insulin-stimulated ANP release through tyrosine kinase and PI 3-kinase in diabetic rats. | 2006 Nov |
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Effects of the phytoestrogen, genistein, and protein tyrosine kinase inhibitor-dependent mechanisms on steroidogenesis and estrogen receptor expression in porcine granulosa cells of medium follicles. | 2013 Jan |
Patents
Sample Use Guides
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8283135
Human neutrophils pretreated with lavendustin C (LVC) at concentrations between 10 and 150 microM or control neutrophils were stimulated by plasma-coated calcium pyrophosphate dihydrate (CPPD) or uncoated monosodium urate monohydrate (MSUM), and chemiluminescence, superoxide generation, intracellular calcium concentration, and degranulation (myeloperoxidase and lysozyme release) were monitored with time. LVC strongly inhibited chemiluminescence, superoxide anion generation, myeloperoxidase and lysozyme release, and calcium mobilization. After 1-min crystal-neutrophil incubations, neutrophil cytosolic fractions showed extensive inhibition of tyrosine kinase activity by LVC.
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:36:08 GMT 2023
by
admin
on
Sat Dec 16 08:36:08 GMT 2023
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Record UNII |
HJM06BIW5M
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Record Status |
Validated (UNII)
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Record Version |
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-
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NCI_THESAURUS |
C1967
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admin on Sat Dec 16 08:36:08 GMT 2023 , Edited by admin on Sat Dec 16 08:36:08 GMT 2023
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C1487
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HJM06BIW5M
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3896
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666251
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125697-93-0
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DTXSID60154856
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admin on Sat Dec 16 08:36:08 GMT 2023 , Edited by admin on Sat Dec 16 08:36:08 GMT 2023
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ACTIVE MOIETY |