DROMETRIZOLE TRISILOXANE

Details

Stereochemistry	RACEMIC
Molecular Formula	C24H39N3O3Si3
Molecular Weight	501.8413
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(CC1=C(O)C(=CC(C)=C1)N2N=C3C=CC=CC3=N2)C[Si](C)(O[Si](C)(C)C)O[Si](C)(C)C

InChI

InChIKey=HUVYTMDMDZRHBN-UHFFFAOYSA-N

InChI=1S/C24H39N3O3Si3/c1-18-14-20(15-19(2)17-33(9,29-31(3,4)5)30-32(6,7)8)24(28)23(16-18)27-25-21-12-10-11-13-22(21)26-27/h10-14,16,19,28H,15,17H2,1-9H3

HIDE SMILES / InChI

Molecular Formula	C24H39N3O3Si3
Molecular Weight	501.8413
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/17805138
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/15379874

Dometrizole trisiloxane (Mexoryl XL®) is a lipophilic benzotriazole derivative used in sunscreen products to absorb ultraviolet (UV). It is a broadspectrum UVB/UVA filter with two peaks of absorption: one at 303 nm and the other one at 344 nm. Sunscreens containing dometrizole trisiloxane (Mexoryl XL®) are important in impeding UVA light, potentially reducing many of the characteristics of skin aging and preventing biochemical changes that can lead to nonmelanoma carcinoma. It has not yet been approved in the US, but has been available worldwide for many years in different sunscreens made by L'Oreal.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Sun intolerance 1 Sources: http://www.laroche-posay.com/products-treatments/Anthelios/Children-s-skin-and-the-sun-r35.aspx	Palliative		Approved 8583	ANTHELIOS Approved Use Sun intolerances commonly called sun allergies. Extreme sunlight.

PubMed

Title	Date	PubMed
Vitamin D levels of XP-patients under stringent sun-protection.	2010-05-25	20494856
Mexoryl: a review of an ultraviolet a filter.	2007-09-15	17805138
Allergic contact dermatitis to drometrizole trisiloxane in a sunscreen with concomitant sensitivities to other sun screens.	2005-04	15859995
Determination of sixteen UV filters in suncare formulations by high-performance liquid chromatography.	2004-09-17	15499924

Patents

Sample Use Guides

In Vivo Use Guide

Apply the sunscreen product just before exposure. Re-apply frequently and generously to maintain protection, especially after perspiring or towelling.

Route of Administration: Topical

In Vitro Use Guide

Suncreen A tested (UVB: Octocrylene; UVA: Mexoryl SX, Mexoryl XL, Parsol 1789; TiO2) provided protection against the development of UV radiation-induced skin lesions in patients with photosensitive lupus erythematosus. This protective capacity was corroborated by studies in which strong ICAM-1 mRNA expression was found in unprotected test areas, but not in sunscreen A pretreated sites.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 23:33:59 GMT 2025` Edited by `admin` on `Mon Mar 31 23:33:59 GMT 2025`
Record UNII	HC22845I1X
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MEXORYL XL

Preferred Name

English

DROMETRIZOLE TRISILOXANE

Official Name

English

Drometrizole trisiloxane [WHO-DD]

Common Name

English

DROMETRIZOLE TRISILOXANE [USP-RS]

Common Name

English

OR 10154

Code

English

SILATRIZOLE

Brand Name

English

PHENOL, 2-(2H-BENZOTRIAZOL-2-YL)-4-METHYL-6-(2-METHYL-3-(1,3,3,3-TETRAMETHYL-1-((TRIMETHYLSILYL)OXY)-1-DISILOXANYL)PROPYL)-

Systematic Name

English

OR-10154

Code

English

PHENOL, 2-(2H-BENZOTRIAZOL-2-YL)-4-METHYL-6-(2-METHYL-3-(1,3,3,3-TETRAMETHYL-1-((TRIMETHYLSILYL)OXY)DISILOXANYL)PROPYL)-

Systematic Name

English

Code System Code Type Description

RXCUI

1992874