OPC-14523 MESYLATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C23H28ClN3O2.CH4O3S
Molecular Weight	510.046
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CS(O)(=O)=O.COC1=C2CCC(=O)N(CCCN3CCN(CC3)C4=CC=CC(Cl)=C4)C2=CC=C1

InChI

InChIKey=LAYQZXHSBQXCFR-UHFFFAOYSA-N

InChI=1S/C23H28ClN3O2.CH4O3S/c1-29-22-8-3-7-21-20(22)9-10-23(28)27(21)12-4-11-25-13-15-26(16-14-25)19-6-2-5-18(24)17-19;1-5(2,3)4/h2-3,5-8,17H,4,9-16H2,1H3;1H3,(H,2,3,4)

HIDE SMILES / InChI

Molecular Formula	CH4O3S
Molecular Weight	96.106
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C23H28ClN3O2
Molecular Weight	413.94
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Effects of OPC-14523, a combined sigma and 5-HT1a ligand, on pre- and post-synaptic 5-HT1a receptors.	2007-01	16533864
In vitro profile of the antidepressant candidate OPC-14523 at rat and human 5-HT1A receptors.	2005-07-11	15985260
Behavioral pharmacology of sigma-ligands.	2004-11	15547784
Effects of the potential antidepressant OPC-14523 [1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2-quinolinone monomethanesulfonate] a combined sigma and 5-HT1A ligand: modulation of neuronal activity in the dorsal raphe nucleus.	2004-08	15044555
Potential antidepressant activity of sigma ligands.	2003-09-30	14730086
Attenuation of scopolamine-induced and age-associated memory impairments by the sigma and 5-hydroxytryptamine(1A) receptor agonist OPC-14523 (1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2[1H]-quinolinone monomethanesulfonate).	2002-04	11907181
Antidepressant-like responses to the combined sigma and 5-HT1A receptor agonist OPC-14523.	2001-12	11747902

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:34:01 GMT 2025` Edited by `admin` on `Mon Mar 31 21:34:01 GMT 2025`
Record UNII	H9J1LZ3AAH
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

OPC-14523 MESYLATE

Code

English

1-(3-(4-(3-CHLOROPHENYL)-1-PIPERAZINYL)PROPYL)-5-METHOXY-3,4-DIHYDRO-2-QUINOLINONE MONOMETHANESULFONATE

Preferred Name

English

2(1H)-QUINOLINONE, 1-(3-(4-(3-CHLOROPHENYL)-1-PIPERAZINYL)PROPYL)-3,4-DIHYDRO-5-METHOXY-, METHANESULFONATE (1:1)

Systematic Name

English

Code System Code Type Description

FDA UNII

H9J1LZ3AAH

Created by admin on Mon Mar 31 21:34:01 GMT 2025 , Edited by admin on Mon Mar 31 21:34:01 GMT 2025

PRIMARY

CAS

260369-93-5

Created by admin on Mon Mar 31 21:34:01 GMT 2025 , Edited by admin on Mon Mar 31 21:34:01 GMT 2025

PRIMARY

DRUG BANK

DBSALT002835

Created by admin on Mon Mar 31 21:34:01 GMT 2025 , Edited by admin on Mon Mar 31 21:34:01 GMT 2025

PRIMARY

PUBCHEM

9892539

Created by admin on Mon Mar 31 21:34:01 GMT 2025 , Edited by admin on Mon Mar 31 21:34:01 GMT 2025

PRIMARY

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