ZALTOPROFEN

Details

Stereochemistry	RACEMIC
Molecular Formula	C17H14O3S
Molecular Weight	298.356
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C(O)=O)C1=CC2=C(SC3=C(C=CC=C3)C(=O)C2)C=C1

InChI

InChIKey=MUXFZBHBYYYLTH-UHFFFAOYSA-N

InChI=1S/C17H14O3S/c1-10(17(19)20)11-6-7-15-12(8-11)9-14(18)13-4-2-3-5-16(13)21-15/h2-8,10H,9H2,1H3,(H,19,20)

HIDE SMILES / InChI

Molecular Formula	C17H14O3S
Molecular Weight	298.356
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: http://www.ncbi.nlm.nih.gov/pubmed/12065695
Curator's Comment: description was created based on several sources, including, http://www.ncbi.nlm.nih.gov/pubmed/16473424

Zaltoprofen is a non-steroidal anti-inflammatory drug approved in Japan for the treatment of lumbar pain, frozen shoulder, osteoarthritis, musculoskeletal pain, dental pain, post-operative pain. The main mechanism of action involves the inhibition of COX-2. Additional mechanism may be associated with the inhibitory effect of zaltoprofen on bradykinin-induced nociceptive responses that happens without blocking bradykinin receptors.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Prostaglandin G/H synthase 2 48 Target ID: P35354 Gene ID: 5743.0 Gene Symbol: PTGS2 Target Organism: Homo sapiens (Human) Sources: www.ncbi.nlm.nih.gov/pubmed/12065695	Inhibitor 8297		0.34 nM [IC50]

Conditions

Condition	Modality	Highest Phase	Product
Rheumatoid arthritis 316 Sources: http://www.rad-ar.or.jp/siori/english/kekka.cgi?n=33385	Palliative	Approved 8429	SOLETON Approved Use It is usually used for anti-inflammation and analgesia in rheumatoid arthritis, osteoarthritis, low back pain, shoulder periarthritis, cervicobrachial syndrome as well as pain after operation, injuries or tooth removal.
Osteoarthritis 157 Sources: http://www.rad-ar.or.jp/siori/english/kekka.cgi?n=33385	Palliative	Approved 8429	SOLETON Approved Use It is usually used for anti-inflammation and analgesia in rheumatoid arthritis, osteoarthritis, low back pain, shoulder periarthritis, cervicobrachial syndrome as well as pain after operation, injuries or tooth removal.
Low back pain 22 Sources: http://www.rad-ar.or.jp/siori/english/kekka.cgi?n=33385	Palliative	Approved 8429	SOLETON Approved Use It is usually used for anti-inflammation and analgesia in rheumatoid arthritis, osteoarthritis, low back pain, shoulder periarthritis, cervicobrachial syndrome as well as pain after operation, injuries or tooth removal.
Shoulder periarthritis 1 Sources: http://www.rad-ar.or.jp/siori/english/kekka.cgi?n=33385	Palliative	Approved 8429	SOLETON Approved Use It is usually used for anti-inflammation and analgesia in rheumatoid arthritis, osteoarthritis, low back pain, shoulder periarthritis, cervicobrachial syndrome as well as pain after operation, injuries or tooth removal.
Post-operational pain 1 Sources: http://www.rad-ar.or.jp/siori/english/kekka.cgi?n=33385	Primary	Approved 8429	SOLETON Approved Use It is usually used for anti-inflammation and analgesia in rheumatoid arthritis, osteoarthritis, low back pain, shoulder periarthritis, cervicobrachial syndrome as well as pain after operation, injuries or tooth removal.

PubMed

Title	Date	PubMed

Patents

Sample Use Guides

In Vivo Use Guide

In general, for adults, take 1 tablet (80 mg of the active ingredient) at a time, 3 times a day. If the medicine is taken as needed, take 1 to 2 tablets (80 mg to 160 mg) at a time.

Route of Administration: Oral

In Vitro Use Guide

The proliferation of rheumatoid synovial cells was studied after incubation with zaltoprofen (300 uM). IC50 value for inhibition of cell viability was 135.2 uM. Zaltoprofen suppressedthecellproliferationin a concentration-dependent manner, with IC50 value of 48.9 uM.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:31:29 UTC 2023` Edited by `admin` on `Fri Dec 15 16:31:29 UTC 2023`
Record UNII	H8635NG3PY
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ZALTOPROFEN

Official Name

English

SORETON

Brand Name

English

CN-100

Code

English

ZALTOPROFEN [MI]

Common Name

English

ZALTOPROFEN [MART.]

Common Name

English

ZALTOPROFEN [JAN]

Common Name

English

Zaltoprofen [WHO-DD]

Common Name

English

PEON

Brand Name

English

zaltoprofen [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C257