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Details

Stereochemistry RACEMIC
Molecular Formula C17H14O3S
Molecular Weight 298.356
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ZALTOPROFEN

SMILES

CC(C(O)=O)C1=CC2=C(SC3=C(C=CC=C3)C(=O)C2)C=C1

InChI

InChIKey=MUXFZBHBYYYLTH-UHFFFAOYSA-N
InChI=1S/C17H14O3S/c1-10(17(19)20)11-6-7-15-12(8-11)9-14(18)13-4-2-3-5-16(13)21-15/h2-8,10H,9H2,1H3,(H,19,20)

HIDE SMILES / InChI

Molecular Formula C17H14O3S
Molecular Weight 298.356
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description

Zaltoprofen is a non-steroidal anti-inflammatory drug approved in Japan for the treatment of lumbar pain, frozen shoulder, osteoarthritis, musculoskeletal pain, dental pain, post-operative pain. The main mechanism of action involves the inhibition of COX-2. Additional mechanism may be associated with the inhibitory effect of zaltoprofen on bradykinin-induced nociceptive responses that happens without blocking bradykinin receptors.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
0.34 nM [IC50]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
SOLETON
Palliative
SOLETON
Palliative
SOLETON
Palliative
SOLETON
Primary
SOLETON

PubMed

Sample Use Guides

In Vivo Use Guide
In general, for adults, take 1 tablet (80 mg of the active ingredient) at a time, 3 times a day. If the medicine is taken as needed, take 1 to 2 tablets (80 mg to 160 mg) at a time.
Route of Administration: Oral
In Vitro Use Guide
The proliferation of rheumatoid synovial cells was studied after incubation with zaltoprofen (300 uM). IC50 value for inhibition of cell viability was 135.2 uM. Zaltoprofen suppressedthecellproliferationin a concentration-dependent manner, with IC50 value of 48.9 uM.
Substance Class Chemical
Record UNII
H8635NG3PY
Record Status Validated (UNII)
Record Version