Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C17H14F3NO3 |
| Molecular Weight | 337.2932 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C[C@](O)(C(=O)NC1=CC=C(C=C1)C(=O)C2=CC=CC=C2)C(F)(F)F
InChI
InChIKey=LVEDGSIMCSQNNX-INIZCTEOSA-N
InChI=1S/C17H14F3NO3/c1-16(24,17(18,19)20)15(23)21-13-9-7-12(8-10-13)14(22)11-5-3-2-4-6-11/h2-10,24H,1H3,(H,21,23)/t16-/m0/s1
| Molecular Formula | C17H14F3NO3 |
| Molecular Weight | 337.2932 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| (-)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637): a novel ATP-sensitive potassium channel opener efficacious in suppressing urinary bladder contractions. II. in vivo characterization. | 2002-10 |
|
| The involvement of L-type Ca(2+) channels in the relaxant effects of the ATP-sensitive K(+) channel opener ZD6169 on pig urethral smooth muscle. | 2001-12 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:03:38 GMT 2025
by
admin
on
Mon Mar 31 18:03:38 GMT 2025
|
| Record UNII |
H6UIO70F5E
|
| Record Status |
Validated (UNII)
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| Record Version |
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H6UIO70F5E
Created by
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177852
Created by
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147696-46-6
Created by
admin on Mon Mar 31 18:03:38 GMT 2025 , Edited by admin on Mon Mar 31 18:03:38 GMT 2025
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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TARGET -> ACTIVATOR |
Opens potassium channel. Test done in Guinea pigs bladder muscle. Inhibition of action potentials and phasic contractions of UBSM. The results suggest that activation of <1% of KATP channels is sufficient to inhibit significantly action potentials and the related phasic contractions.
K1/2
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TARGET -> ACTIVATOR |
Opens potassium channel. Test done in Guinea pigs bladder muscle. Half maximal activation of potassium current.
K1/2
|
