PHYSCIONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H12O5
Molecular Weight	284.2635
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC(O)=C2C(=O)C3=C(C=C(C)C=C3O)C(=O)C2=C1

InChI

InChIKey=FFWOKTFYGVYKIR-UHFFFAOYSA-N

InChI=1S/C16H12O5/c1-7-3-9-13(11(17)4-7)16(20)14-10(15(9)19)5-8(21-2)6-12(14)18/h3-6,17-18H,1-2H3

HIDE SMILES / InChI

Molecular Formula	C16H12O5
Molecular Weight	284.2635
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
AMPK signaling pathway 7 Target ID: map04152 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26144377	Modulator 846
HIF-1 signaling pathway 1 Target ID: map04066 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26144377	Modulator 846
Homeobox protein Hox-A5 1 Target ID: P20719 Gene ID: 3202.0 Gene Symbol: HOXA5 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/28810515	Inhibitor 8504

PubMed

Title	Date	PubMed
Pharmacokinetics of anthraquinones in Xiexin decoction and in different combinations of its constituent herbs.	2009-03	18844291
Structural elucidation of in vitro metabolites of emodin by liquid chromatography-tandem mass spectrometry.	2008-11	18651591
Anthraquinone pharmacokinetics in Xiexin decoction and the different combinations of its constituent herbs.	2008-09-10	18777942
Anthraquinone-benzisochromanquinone dimers from the roots of Berchemia floribunda.	2008-09	18758095
Development and validation of a UPLC method for quality control of rhubarb-based medicine: fast simultaneous determination of five anthraquinone derivatives.	2008-08-05	18440751
Phenols from the roots of Rheum palmatum attenuate chemotaxis in rat hepatic stellate cells.	2008-08	18612943
Simultaneous determination of anthraquinones in radix Polygoni multiflori by capillary gas chromatography coupled with flame ionization and mass spectrometric detection.	2008-07-18	18262194
Anti-proliferative effects of estrogen receptor-modulating compounds isolated from Rheum palmatum.	2008-06	18563353
Study of interactions of anthraquinones with DNA using ethidium bromide as a fluorescence probe.	2008-06	17825605
Tolerance of the lichen Xanthoria parietina (L.) Th. Fr. to metal stress.	2008-06	17512591
[Studies on chemical constituents and volatile oil of Xiaochengqi decoction].	2008-05	18652350
Lipoxygenase inhibitory constituents from rhubarb.	2008-05	18481015
Simultaneous determination of eight major bioactive compounds in Dachengqi Tang (DT) by high-performance liquid chromatography.	2008-04-29	18445276
A new spiroketal from Aspergillus terreus, an endophytic fungus in Opuntia ficusindica Mill.	2008-04	18383227
Anthraquinones from Polygonum cuspidatum as tyrosinase inhibitors for dermal use.	2008-04	18338768
[Theoretical and experimental studies on solubility parameters of multiple components for traditional Chinese materia medica with HPLC].	2008-03	18590190
[A new qualitative and quantitative analytical method of chromatographic fingerprints: total quantum statistical moment].	2008-02	18507349
Purification of hydroxyanthraquinones and cinnamic acid from the roots of Rheum officinale Baill.	2008-02	18183553
Simultaneous identification and quantification of anthraquinones, polydatin, and resveratrol in Polygonum multiflorum, various Polygonum species, and dietary supplements by liquid chromatography and microscopic study of Polygonum species.	2008-01-16	18193729
Determination of pharmacologically active compounds in root extracts of Cassia alata L. by use of high performance liquid chromatography.	2008-01-15	18371725
Optimization and validation of a chromatographic method for the simultaneous quantification of six bioactive compounds in Rhizoma et Radix Polygoni Cuspidati.	2008-01	18088511
Penicidones A-C, three cytotoxic alkaloidal metabolites of an endophytic Penicillium sp.	2008-01	17804027
Prenylated anthraquinones and other constituents from the seeds of Vismia laurentii.	2007-11	17978527
Anthraquinones from the seeds of Cassia tora with inhibitory activity on protein glycation and aldose reductase.	2007-11	17978503
Lichen secondary metabolites from the cultured lichen mycobionts of Teloschistes chrysophthalmus and Ramalina celastri and their antiviral activities.	2007-10-05	17913069
[Study on correlation of soil nutrients and content of active constituents in root of Rumex gmelini].	2007-10	18161286
A new isocoumarin from Hypericum annulatum.	2007-10	17852739
In situ synthesis of molecularly imprinted polymers on glass microspheres in a column.	2007-10	17786412
[Application of macroporous resin in purification for effective part from Polygonum cuspidatum].	2007-06	17672332
Anthraquinones, Cdc25B phosphatase inhibitors, isolated from the roots of Polygonum multiflorum Thunb.	2007-05-20	17497420
Synergistic interaction of physcion and chrysophanol on plant powdery mildew.	2007-05	17397111
Simultaneous quantification of five anthraquinones in rat plasma by high-performance liquid chromatography with fluorescence detection.	2007-05	17294506
Simultaneous analysis of eight bioactive compounds in Danning tablet by HPLC-ESI-MS and HPLC-UV.	2007-02-19	17079108
Antimicrobial activity of the methanolic extracts and compounds from Vismia laurentii De Wild (Guttiferae).	2007-02-12	16971076
Alterations in secondary metabolism of aposymbiotically grown mycobionts of Xanthoria elegans and cultured resynthesis stages.	2007-02	17344057
Rapid separation and determination of structurally related anthraquinones in Rhubarb by pressurized capillary electrochromatography.	2007-01-04	16875795
Preparative isolation and purification of hydroxyanthraquinones from Rheum tanguticum Maxim. on normal phase silica gel: using a Flash Master Personal system.	2007	17516248
Anti-HIV-1 constituents from leaves and twigs of Cratoxylum arborescens.	2006-12	17091434
Chaetopyranin, a benzaldehyde derivative, and other related metabolites from Chaetomium globosum, an endophytic fungus derived from the marine red alga Polysiphonia urceolata.	2006-11	17125234
[Effect of preparation on the major chemical constituents of Polygonum multiflorum].	2006-10	17326399
[Isolation of the chemical constituents from Shuanghuanglian injection and their structural identification].	2006-10	17062354
[Induction of hairy roots and anthraquinone production in Rheum palmatum].	2006-09	17144464
Supercritical CO2 extraction of emodin and physcion from Polygonum cuspidatum and subsequent isolation by semipreparative chromatography.	2006-09	17069242
A new anthraquinone from Galium verum L.	2006-09	17050180
Neoplaether, a new cytotoxic and antifungal endophyte metabolite from Neoplaconema napellum IFB-E016.	2006-08	16907723
New flavonol glycosides and new xanthone from Polygala japonica.	2006-07-26	16864455
Laurentixanthones A and B, antimicrobial xanthones from Vismia laurentii.	2006-07	16740282
[HPLC fingerprint of Rhizoma Polygoni Cuspidati].	2006-06	17048640
[Studies on the chemical constituents in stem rind of Wikstroemia indica].	2006-05	17048664
[Studies on chemical constituents of hairy root of Cassia obtusifolia].	2006-02	16573002

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:30:26 GMT 2025` Edited by `admin` on `Mon Mar 31 19:30:26 GMT 2025`
Record UNII	H6PT94IV61
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PHYSCIONE

Common Name

English

EMODIN 3-METHYL ETHER

Preferred Name

English

PHYSCION

Common Name

English

ANTHRAQUINONE, 1,8-DIHYDROXY-3-METHOXY-6-METHYL-

Systematic Name

English

RHEOCHRYSIDIN

Common Name

English

1,8-DIHYDROXY-3-METHOXY-6-METHYLANTHRAQUINONE

Systematic Name

English

NSC-251670

Code

English

CHRYSOPHANIC ACID, 6-METHOXY-

Common Name

English

PARIETIN

Common Name

English

EMODIN 3-METHYL ETHER [MI]

Common Name

English

6-O-METHYLEMODIN

Common Name

English

PHYSCIONE-

Common Name

English

Code System Code Type Description

EVMPD

SUB33881