U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C16H12O5
Molecular Weight 284.2635
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PHYSCIONE

SMILES

COC1=CC2=C(C(O)=C1)C(=O)C3=C(C=C(C)C=C3O)C2=O

InChI

InChIKey=FFWOKTFYGVYKIR-UHFFFAOYSA-N
InChI=1S/C16H12O5/c1-7-3-9-13(11(17)4-7)16(20)14-10(15(9)19)5-8(21-2)6-12(14)18/h3-6,17-18H,1-2H3

HIDE SMILES / InChI

Molecular Formula C16H12O5
Molecular Weight 284.2635
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: P20719
Gene ID: 3202.0
Gene Symbol: HOXA5
Target Organism: Homo sapiens (Human)
PubMed

PubMed

TitleDatePubMed
Evaluation of the antiviral activity of anthraquinones, anthrones and anthraquinone derivatives against human cytomegalovirus.
1992 Jan
Antifungal activity of anthraquinone derivatives from Rheum emodi.
2000 Sep
Discovery, total synthesis, HRV 3C-protease inhibitory activity, and structure-activity relationships of 2-methoxystypandrone and its analogues.
2001 Dec 17
Determination of pKa values of anthraquinone compounds by capillary electrophoresis.
2001 Feb
Immune reponses in human mesangial cells regulated by emodin from Polygonum hypoleucum Ohwi.
2001 Feb 2
Cytotoxic principles from Ventilago leiocarpa.
2001 May
[Studies on chemical constituents of Bletilla striata (Thunb) Reichb. f].
2001 Oct
[Studies on the chemical constituents of the stems of Alyxia sinensis (I)].
2002 Feb
[Study on the quantitative change of anthraquinonoids of Rhei in the preparation of dachengqi].
2002 Jan
Racemochrysone, a dihydroanthracenone from Senna racemosa.
2002 Sep-Oct
Is parietin a UV-B or a blue-light screening pigment in the lichen Xanthoria parietina?
2003 Apr
Simultaneous determination of hydroxyanthraquinones in rhubarb and experimental animal bodies by high-performance liquid chromatography.
2003 Aug
[Phenolic compounds isolated from rhizoma of Aster tataricus].
2003 Oct
A new triterpenoid from Entodon okamurae Broth.
2003 Sep
The potential of the lichen symbiosis to cope with the extreme conditions of outer space II: germination capacity of lichen ascospores in response to simulated space conditions.
2004
Inhibition of MAO A and B by some plant-derived alkaloids, phenols and anthraquinones.
2004 Apr
Anti-proliferative lichen compounds with inhibitory activity on 12(S)-HETE production in human platelets.
2004 Nov
Aspergillus fumigatus CY018, an endophytic fungus in Cynodon dactylon as a versatile producer of new and bioactive metabolites.
2004 Nov 9
Separation and determination of four active anthraquinones in Chinese herbal preparations by flow injection-capillary electrophoresis.
2005 Aug
PTP1B inhibitors from Ardisia japonica.
2005 Feb
[Studies on the chemical constituents in herb of Mentha haplocalyx].
2005 Jul
[Influence of processing rhubarb on it's anthraquinone contents].
2005 Jun
[Study on the optimal harvesting time of Rumex gmelini by analyzing the contents of principal components].
2005 Jun
Lichen palatability depends on investments in herbivore defence.
2005 Mar
Simultaneous determination of anthraquinones in Rhubarb by pressurized liquid extraction and capillary zone electrophoresis.
2005 May
[Studies on chemical constituents of hairy root of Cassia obtusifolia].
2006 Feb
[Simultaneous determination of resveratrol, emodin, chrysophanol, physcion, in root of Polygonam cuspidatum and its extract by HPLC].
2006 Feb
[Effect of preparation on the major chemical constituents of Polygonum multiflorum].
2006 Oct
[Isolation of the chemical constituents from Shuanghuanglian injection and their structural identification].
2006 Oct
[Induction of hairy roots and anthraquinone production in Rheum palmatum].
2006 Sep
Antimicrobial activity of the methanolic extracts and compounds from Vismia laurentii De Wild (Guttiferae).
2007 Feb 12
Lichen secondary metabolites from the cultured lichen mycobionts of Teloschistes chrysophthalmus and Ramalina celastri and their antiviral activities.
2007 Jul-Aug
[Application of macroporous resin in purification for effective part from Polygonum cuspidatum].
2007 Jun
Prenylated anthraquinones and other constituents from the seeds of Vismia laurentii.
2007 Nov
Anthraquinones from the seeds of Cassia tora with inhibitory activity on protein glycation and aldose reductase.
2007 Nov
Simultaneous identification and quantification of anthraquinones, polydatin, and resveratrol in Polygonum multiflorum, various Polygonum species, and dietary supplements by liquid chromatography and microscopic study of Polygonum species.
2007 Nov-Dec
[Study on correlation of soil nutrients and content of active constituents in root of Rumex gmelini].
2007 Oct
A new isocoumarin from Hypericum annulatum.
2007 Oct
In situ synthesis of molecularly imprinted polymers on glass microspheres in a column.
2007 Oct
Anthraquinone pharmacokinetics in Xiexin decoction and the different combinations of its constituent herbs.
2008 Apr-Jun
Development and validation of a UPLC method for quality control of rhubarb-based medicine: fast simultaneous determination of five anthraquinone derivatives.
2008 Aug 5
Purification of hydroxyanthraquinones and cinnamic acid from the roots of Rheum officinale Baill.
2008 Feb
Optimization and validation of a chromatographic method for the simultaneous quantification of six bioactive compounds in Rhizoma et Radix Polygoni Cuspidati.
2008 Jan
Penicidones A-C, three cytotoxic alkaloidal metabolites of an endophytic Penicillium sp.
2008 Jan
Study of interactions of anthraquinones with DNA using ethidium bromide as a fluorescence probe.
2008 Jun
[Theoretical and experimental studies on solubility parameters of multiple components for traditional Chinese materia medica with HPLC].
2008 Mar
Patents

Patents

Substance Class Chemical
Created
by admin
on Fri Dec 15 19:01:19 GMT 2023
Edited
by admin
on Fri Dec 15 19:01:19 GMT 2023
Record UNII
H6PT94IV61
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PHYSCIONE
Common Name English
PHYSCION
Common Name English
ANTHRAQUINONE, 1,8-DIHYDROXY-3-METHOXY-6-METHYL-
Systematic Name English
RHEOCHRYSIDIN
Common Name English
1,8-DIHYDROXY-3-METHOXY-6-METHYLANTHRAQUINONE
Systematic Name English
NSC-251670
Code English
CHRYSOPHANIC ACID, 6-METHOXY-
Common Name English
PARIETIN
Common Name English
EMODIN 3-METHYL ETHER [MI]
Common Name English
EMODIN 3-METHYL ETHER
MI  
Common Name English
6-O-METHYLEMODIN
Common Name English
PHYSCIONE-
Common Name English
Code System Code Type Description
EVMPD
SUB33881
Created by admin on Fri Dec 15 19:01:19 GMT 2023 , Edited by admin on Fri Dec 15 19:01:19 GMT 2023
PRIMARY
CAS
521-61-9
Created by admin on Fri Dec 15 19:01:19 GMT 2023 , Edited by admin on Fri Dec 15 19:01:19 GMT 2023
PRIMARY
EPA CompTox
DTXSID20200101
Created by admin on Fri Dec 15 19:01:19 GMT 2023 , Edited by admin on Fri Dec 15 19:01:19 GMT 2023
PRIMARY
MESH
C008905
Created by admin on Fri Dec 15 19:01:19 GMT 2023 , Edited by admin on Fri Dec 15 19:01:19 GMT 2023
PRIMARY
PUBCHEM
10639
Created by admin on Fri Dec 15 19:01:19 GMT 2023 , Edited by admin on Fri Dec 15 19:01:19 GMT 2023
PRIMARY
FDA UNII
H6PT94IV61
Created by admin on Fri Dec 15 19:01:19 GMT 2023 , Edited by admin on Fri Dec 15 19:01:19 GMT 2023
PRIMARY
CHEBI
38167
Created by admin on Fri Dec 15 19:01:19 GMT 2023 , Edited by admin on Fri Dec 15 19:01:19 GMT 2023
PRIMARY
MERCK INDEX
m4888
Created by admin on Fri Dec 15 19:01:19 GMT 2023 , Edited by admin on Fri Dec 15 19:01:19 GMT 2023
PRIMARY Merck Index
NSC
251670
Created by admin on Fri Dec 15 19:01:19 GMT 2023 , Edited by admin on Fri Dec 15 19:01:19 GMT 2023
PRIMARY
ECHA (EC/EINECS)
208-315-7
Created by admin on Fri Dec 15 19:01:19 GMT 2023 , Edited by admin on Fri Dec 15 19:01:19 GMT 2023
PRIMARY
SMS_ID
100000127769
Created by admin on Fri Dec 15 19:01:19 GMT 2023 , Edited by admin on Fri Dec 15 19:01:19 GMT 2023
PRIMARY
WIKIPEDIA
PARIETIN
Created by admin on Fri Dec 15 19:01:19 GMT 2023 , Edited by admin on Fri Dec 15 19:01:19 GMT 2023
PRIMARY
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ACTIVE MOIETY