PHYSCIONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H12O5
Molecular Weight	284.2635
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC2=C(C(O)=C1)C(=O)C3=C(C=C(C)C=C3O)C2=O

InChI

InChIKey=FFWOKTFYGVYKIR-UHFFFAOYSA-N

InChI=1S/C16H12O5/c1-7-3-9-13(11(17)4-7)16(20)14-10(15(9)19)5-8(21-2)6-12(14)18/h3-6,17-18H,1-2H3

HIDE SMILES / InChI

Molecular Formula	C16H12O5
Molecular Weight	284.2635
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
AMPK signaling pathway 5 Target ID: map04152 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26144377	Modulator 828
HIF-1 signaling pathway 1 Target ID: map04066 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26144377	Modulator 828
Homeobox protein Hox-A5 1 Target ID: P20719 Gene ID: 3202.0 Gene Symbol: HOXA5 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/28810515	Inhibitor 8297

PubMed

Title	Date	PubMed
New and cytotoxic anthraquinones from Pleospora sp. IFB-E006, an endophytic fungus in Imperata cylindrical.	2005 Nov	16320210
Anti-HIV-1 constituents from leaves and twigs of Cratoxylum arborescens.	2006 Dec	17091434
[Studies on chemical constituents of hairy root of Cassia obtusifolia].	2006 Feb	16573002
[Simultaneous determination of resveratrol, emodin, chrysophanol, physcion, in root of Polygonam cuspidatum and its extract by HPLC].	2006 Feb	16572998
Laurentixanthones A and B, antimicrobial xanthones from Vismia laurentii.	2006 Jul	16740282
[HPLC fingerprint of Rhizoma Polygoni Cuspidati].	2006 Jun	17048640
[Studies on the chemical constituents in stem rind of Wikstroemia indica].	2006 May	17048664
Annual variation in photo acclimation and photoprotection of the photobiont in the foliose lichen Xanthoria parietina.	2006 May 1	16481192
Chaetopyranin, a benzaldehyde derivative, and other related metabolites from Chaetomium globosum, an endophytic fungus derived from the marine red alga Polysiphonia urceolata.	2006 Nov	17125234
[Effect of preparation on the major chemical constituents of Polygonum multiflorum].	2006 Oct	17326399
[Isolation of the chemical constituents from Shuanghuanglian injection and their structural identification].	2006 Oct	17062354
[Induction of hairy roots and anthraquinone production in Rheum palmatum].	2006 Sep	17144464
Supercritical CO2 extraction of emodin and physcion from Polygonum cuspidatum and subsequent isolation by semipreparative chromatography.	2006 Sep	17069242
A new anthraquinone from Galium verum L.	2006 Sep	17050180
Preparative isolation and purification of hydroxyanthraquinones from Rheum tanguticum Maxim. on normal phase silica gel: using a Flash Master Personal system.	2007	17516248
Alterations in secondary metabolism of aposymbiotically grown mycobionts of Xanthoria elegans and cultured resynthesis stages.	2007 Feb	17344057
Antimicrobial activity of the methanolic extracts and compounds from Vismia laurentii De Wild (Guttiferae).	2007 Feb 12	16971076
Simultaneous analysis of eight bioactive compounds in Danning tablet by HPLC-ESI-MS and HPLC-UV.	2007 Feb 19	17079108
Lichen secondary metabolites from the cultured lichen mycobionts of Teloschistes chrysophthalmus and Ramalina celastri and their antiviral activities.	2007 Jul-Aug	17913069
[Application of macroporous resin in purification for effective part from Polygonum cuspidatum].	2007 Jun	17672332
Synergistic interaction of physcion and chrysophanol on plant powdery mildew.	2007 May	17397111
Simultaneous quantification of five anthraquinones in rat plasma by high-performance liquid chromatography with fluorescence detection.	2007 May	17294506
Anthraquinones, Cdc25B phosphatase inhibitors, isolated from the roots of Polygonum multiflorum Thunb.	2007 May 20	17497420
Prenylated anthraquinones and other constituents from the seeds of Vismia laurentii.	2007 Nov	17978527
Anthraquinones from the seeds of Cassia tora with inhibitory activity on protein glycation and aldose reductase.	2007 Nov	17978503
Simultaneous identification and quantification of anthraquinones, polydatin, and resveratrol in Polygonum multiflorum, various Polygonum species, and dietary supplements by liquid chromatography and microscopic study of Polygonum species.	2007 Nov-Dec	18193729
[Study on correlation of soil nutrients and content of active constituents in root of Rumex gmelini].	2007 Oct	18161286
A new isocoumarin from Hypericum annulatum.	2007 Oct	17852739
In situ synthesis of molecularly imprinted polymers on glass microspheres in a column.	2007 Oct	17786412
A new spiroketal from Aspergillus terreus, an endophytic fungus in Opuntia ficusindica Mill.	2008 Apr	18383227
Anthraquinones from Polygonum cuspidatum as tyrosinase inhibitors for dermal use.	2008 Apr	18338768
Simultaneous determination of eight major bioactive compounds in Dachengqi Tang (DT) by high-performance liquid chromatography.	2008 Apr 29	18445276
Anthraquinone pharmacokinetics in Xiexin decoction and the different combinations of its constituent herbs.	2008 Apr-Jun	18777942
Phenols from the roots of Rheum palmatum attenuate chemotaxis in rat hepatic stellate cells.	2008 Aug	18612943
Development and validation of a UPLC method for quality control of rhubarb-based medicine: fast simultaneous determination of five anthraquinone derivatives.	2008 Aug 5	18440751
[A new qualitative and quantitative analytical method of chromatographic fingerprints: total quantum statistical moment].	2008 Feb	18507349
Purification of hydroxyanthraquinones and cinnamic acid from the roots of Rheum officinale Baill.	2008 Feb	18183553
Optimization and validation of a chromatographic method for the simultaneous quantification of six bioactive compounds in Rhizoma et Radix Polygoni Cuspidati.	2008 Jan	18088511
Penicidones A-C, three cytotoxic alkaloidal metabolites of an endophytic Penicillium sp.	2008 Jan	17804027
Determination of pharmacologically active compounds in root extracts of Cassia alata L. by use of high performance liquid chromatography.	2008 Jan 15	18371725
Simultaneous determination of anthraquinones in radix Polygoni multiflori by capillary gas chromatography coupled with flame ionization and mass spectrometric detection.	2008 Jul 18	18262194
Anti-proliferative effects of estrogen receptor-modulating compounds isolated from Rheum palmatum.	2008 Jun	18563353
Study of interactions of anthraquinones with DNA using ethidium bromide as a fluorescence probe.	2008 Jun	17825605
Tolerance of the lichen Xanthoria parietina (L.) Th. Fr. to metal stress.	2008 Jun	17512591
[Theoretical and experimental studies on solubility parameters of multiple components for traditional Chinese materia medica with HPLC].	2008 Mar	18590190
[Studies on chemical constituents and volatile oil of Xiaochengqi decoction].	2008 May	18652350
Lipoxygenase inhibitory constituents from rhubarb.	2008 May	18481015
Structural elucidation of in vitro metabolites of emodin by liquid chromatography-tandem mass spectrometry.	2008 Nov	18651591
Anthraquinone-benzisochromanquinone dimers from the roots of Berchemia floribunda.	2008 Sep	18758095
Pharmacokinetics of anthraquinones in Xiexin decoction and in different combinations of its constituent herbs.	2009 Mar	18844291

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:01:19 UTC 2023` Edited by `admin` on `Fri Dec 15 19:01:19 UTC 2023`
Record UNII	H6PT94IV61
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PHYSCIONE

Common Name

English

PHYSCION

Common Name

English

ANTHRAQUINONE, 1,8-DIHYDROXY-3-METHOXY-6-METHYL-

Systematic Name

English

RHEOCHRYSIDIN

Common Name

English

1,8-DIHYDROXY-3-METHOXY-6-METHYLANTHRAQUINONE

Systematic Name

English

NSC-251670

Code

English

CHRYSOPHANIC ACID, 6-METHOXY-

Common Name

English

PARIETIN

Common Name

English

EMODIN 3-METHYL ETHER [MI]

Common Name

English

EMODIN 3-METHYL ETHER

Common Name

English

6-O-METHYLEMODIN

Common Name

English

PHYSCIONE-

Common Name

English

Code System Code Type Description

EVMPD

SUB33881